Phenolic constituents, antioxidant and α-amylase inhibitory activities of Pulicaria vulgarisgrowing in Tunisia: anin vitroandin silicostudy

Jlizi, Salma; Lazrag, Houda; Majdoub, Yassine Oulad El; Zardi‐Bergaoui, Afifa; Cacciola, Francesco; Mondello, Luigi; Harrath, Abdel Halim; Jannet, Hichem Ben

doi:10.1080/11263504.2022.2089760

Cited by 4 publications

(3 citation statements)

References 49 publications

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“…Apigenin glucoside malonate Dittrichia viscosa [71] Apigenin 7-O-glucuronide (CID: 5319484) Synonym: Scutellarin A Inula japonica [72] Apigenin O-hexuronide Telekia speciosa [63] Apigenin dihexoside Pulicaria vulgaris [73] Apigenin Asteriscus graveolens [192] [123]…”

Section: Synonym: Salipurpinmentioning

confidence: 99%

“…[56] [22,159] Catechin hydrate Dittrichia viscosa [100] Catechin hexoside Dittrichia viscosa [140] Catechin gallate (CID: 6419835) Inula helenium; I. racemosa [21,172] Methylcatechin Pulicaria vulgaris. [73] (-)-Epicatechin (CID: 72276)…”

Section: Synonym: Salipurpinmentioning

confidence: 99%

“…Except for the most found caffeoylquinic acids, monoacyl-, diacyl-and triacylquinic acids (conjugates with ferulic, p-coumaric and caffeic acid) or caffeoylquinates substituted with short-chain organic acids (isobutyric, methylbutyric and others) were often identified in the extracts of the Inuleae-Inulinae, mostly using HPLC-MS techniques [54,63,76,99,124,125,131,143,161,168,172,184,215,224,[328][329][330][331][332]. Metabolomic studies, performed using the hyphenated methods, revealed the presence of conjugates of hydroxycinnamic acids with shikimic acid in D. cappa [329], D. nervosa [330] and D. viscosa [170] and conjugates of hydroxycinnamic acids with aldaric acids in B. megacephala, B. riparia [124], B. speciosissimum [161], C. divaricatum [328], C. glutinosus [76], D. viscosa [136,333], I. helenium [334], I. japonica [72], I. sarana [54], P. spinosa [205], P. vulgaris [73] and P. inuloides [184]. Caffeoyltartaric acid (caftaric acid) and 2,3dicaffeoyltartaric acid (chicoric acid) were isolated from roots of I. helenium [335].…”

Section: Hydroxycinnamatesmentioning

confidence: 99%

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Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Malarz,

Michalska,

Stojakowska

2024

Preprint

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Polyphenols are ubiquitous plant metabolites that demonstrate biological activities essential to the plant-environment interactions. They are of interest to plant food consumers, as well as to the food, pharmaceutical and cosmetic industry. The class of the plant metabolites comprises both widespread (chlorogenic acids, luteolin, quercetin) and unique compounds of diverse chemical structures but of the common biosynthetic origin. Polyphenols, next to sesquiterpenoids are regarded as the major class of the Inuleae-Inulinae metabolites responsible for the pharmacological activity of medicinal plants from the subtribe (Blumea spp., Dittrichia spp., Inula spp., Pulicaria spp. and others). Recent decades have brought a rapid development of molecular and analytical techniques which resulted in better understanding of the taxonomic relationships within the Inuleae tribe and in a plethora of data concerning the chemical constituents of the Inuleae-Inulinae. The current taxonomical classification has introduced changes in the well-established botanical names and rearranged the genera based on molecular plant genetic studies. The newly created chemical data together with the earlier phytochemical studies may provide some complementary information on biochemical relationships within the subtribe. Moreover, they may at least partly explain pharmacological activities of the plant preparations traditionally used in therapy. The current review aimed to systematize the knowledge on the polyphenols of the Inulae-Inulinae.

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Section: Synonym: Salipurpinmentioning

confidence: 99%

Section: Synonym: Salipurpinmentioning

confidence: 99%

Section: Hydroxycinnamatesmentioning

confidence: 99%

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Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Malarz,

Michalska,

Stojakowska

2024

Preprint

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Phenolic Profile, Bioactivities and In Silico Analysis of the Trunk Bark of Acacia Cyanophylla Lindl.

Beyaoui,

Kaplan,

Saidi

et al. 2024

Chemistry & Biodiversity

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In the current investigation, total phenolics and flavonoids of the methanolic extract obtained from the trunk bark of Acacia cyanophylla Lindl. were quantified by LC–HRMS technique. DPPH and ABTS reagents were employed to assay the antioxidant potential. The anti‐tyrosinase and anti‐α‐amylase potentials were also assayed. The findings revealed that thirteen polyphenolic compounds were detected in the methanolic extract with trans‐taxifolin (23.2 g/kg), as the major constituent. A. cyanophylla extract displayed a higher activity with DPPH test (IC50=10.14±1.00 μg/mL) than with ABTS (IC50=15.27±2.09 μg/mL). The same extract also exhibited interesting α‐amylase inhibitory action (IC50 value of 4.00±0.17 μg/mL). Moreover, methanolic trunk bark extract exerted strong anti‐tyrosinase capacity with an IC50 of 5.12±0.41 μg/mL in comparison to kojic acid (IC50=10.22±0.85 μg/mL) used as positive control. The antioxidant, anti‐tyrosinase and anti‐α‐amylase potentials of the methanolic extract of A. cyanophylla trunk bark were reinforced by in silico molecular docking analyses, which confirmed the results of the in vitro tests.

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Phytochemistry and Biological Assessment of Thuja articulata Trunk Barks: HPLC-PDA-ESI-MS Analysis, Bioevaluation, and Molecular Docking

Jannet

Algethami

Jlizi

et al. 2024

CBC

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Background: Thuja articulata is a Mediterranean forest species from the Cupressaceae family, it has been used in popular medicine to treat several diseases. Various studies have been carried out in vitro using diverse T. articulata extracts to understand its traditional use. Methods: In this study, the ethyl acetate extract of T. articulata trunk barks was chemically identified using HPLC-PDA-ESI-MS, then examined in vitro for its antioxidant and α-amylase inhibitory effects. A molecular docking study was also performed to reinforce the noted bioactivities. Results: HPLC-PDA-ESI-MS analysis led to the identification of 22 polyphenolic compounds in the ethyl acetate extract of T. articulata trunk barks. This extract revealed interesting in vitro antioxidant properties and a significant α-amylase inhibitory action (IC50= 16.08 ± 1.27 μg/mL). In silico analysis was found to agree with the in vitro studies in which major constituents of the ethyl acetate extract revealed low binding energy and a correct mode of interaction in the active pocket of the enzyme (PDB: 7TAA). The anti--amylase potential could be due either to a synergistic or individual action of certain constituents present in this extract. Conclusion: This study illustrates that the ethyl acetate extract of T. articulata trunk barks has potent sources of antioxidants and α-amylase inhibitors to be explored.

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Phenolic constituents, antioxidant and α-amylase inhibitory activities of Pulicaria vulgarisgrowing in Tunisia: anin vitroandin silicostudy

Cited by 4 publications

References 49 publications

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Phenolic Profile, Bioactivities and In Silico Analysis of the Trunk Bark of Acacia Cyanophylla Lindl.

Phytochemistry and Biological Assessment of Thuja articulata Trunk Barks: HPLC-PDA-ESI-MS Analysis, Bioevaluation, and Molecular Docking

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