Phenolic constituents from the tree barks of garcinia cf cymosa and their antioxidant and antibacterial activities

Yuliar,; Manjang, Yunazar; Ibrahim, S. A.; Achmad, Sjamsul A.

doi:10.11113/mjfas.v9n3.94

Cited by 2 publications

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“…Isoflavonoids have a very restricted distribution in the plant kingdom and occur almost exclusively in the Leguminosae family (Silva et al , ), along with isoflavans such as liquiritegenin ( 2 ) and medicarpin ( 5 ) which have been previously isolated from Cuban and northern Brazilian red propolis, which originates largely from Dalbergia ecastophyllum resin (Piccinelli et al , ). The Nigerian red propolis, according to LC‐MS profiling, also contains polyprenylated benzophenones ( unknowns 14–16 ) that are typically found in Brazilian and Cuban propolis and originate from Clusiaceae species (Yang et al , ; Yuliar et al , ). However, in Nigeria a likely source would be the African mangosteen ( Garcinia livingstonei ) (Yang et al , ).…”

Section: Resultsmentioning

confidence: 99%

Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei

Omar

Igoli

Gray

et al. 2015

Phytochemical Analysis

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Introduction A previous study showed the unique character of Nigerian red propolis from Rivers State, Nigeria (RSN), with regards to chemical composition and activity against Trypanosoma brucei in comparison with other African propolis. Objective To carry out fractionation and biological testing of Nigerian propolis in order to isolate compounds with anti‐trypanosomal activity. To compare the composition of the RSN propolis with the composition of Brazilian red propolis. Methodology Profiling was carried out using HPLC‐UV‐ELSD and HPLC‐Orbitrap‐FTMS on extracts of two samples collected from RSN with data extraction using MZmine software. Isolation was carried out by normal phase and reversed phase MPLC. Elucidation of the compounds with a purity > 95% was performed by 1D/2D NMR HRMS and HRLC‐MSn. Results Ten phenolic compounds were isolated or in the case of liquiritigenin partially purified. Data for nine of these correlated with literature reports of known compounds i.e. one isoflavanone, calycosin (1); two flavanones, liquiritigenin (2) and pinocembrin (5); an isoflavan, vestitol (3); a pterocarpan, medicarpin (4); two prenylflavanones, 8‐prenylnaringenin (7) and 6‐prenylnaringenin (8); and two geranyl flavonoids, propolin D (9) and macarangin (10). The tenth was elucidated as a previously undescribed dihydrobenzofuran (6). The isolated compounds were tested against Trypanosoma brucei and displayed moderate to high activity. Some of the compounds tested had similar activity against wild type T. brucei and two strains displaying pentamidine resistance. Conclusion Nigerian propolis from RSN has some similarities with Brazilian red propolis. The propolis displayed anti‐trypanosomal activity at a potentially useful level. Copyright © 2015 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei

Omar

Igoli

Gray

et al. 2015

Phytochemical Analysis

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“…The 1 H NMR spectra of compounds (1) and (2) showed an anomeric proton signal at δ 4.62 (d, 2H), confirming the presence of a sugar residue ( table 1 ). The position for the attachment of sugar residue of both compounds was C-6 since the proton signals at position C-5 ( δ 7.15 and 7.18 ppm for compounds (1) and (2), respectively) were shifted to those reported in the literature for β-mangostin [ 19 ]. The sugar moiety of compound (1) was 2-deoxyglucose as the signals of protons of C-2′ appeared at δ 2.27 and 1.35 ppm ( table 1 ) [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Bioactivities of β-mangostin and its new glycoside derivatives synthesized by enzymatic reactions

Trang

Pham

et al. 2023

R. Soc. open sci.

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Beta-mangostin is a xanthone commonly found in the genus Garcinia . Unlike α-mangostin, to date, there have only been a few studies on the biological activity and derivatization of β-mangostin. In this study, two novel glycosylated derivatives of β-mangostin were successfully synthesized via a one-pot enzymatic reaction. These derivatives were characterized as β-mangostin 6-O-β- d -glucopyranoside and β-mangostin 6-O-β- d -2-deoxyglucopyranoside by TOF ESI/MS and 1 H and 13 C NMR analyses. Beta-mangostin showed cytotoxicity against KB, MCF7, A549 and HepG2 cancer cell lines, with IC 50 values ranging from 15.42 to 21.13 µM. The acetylcholinesterase and α-glucosidase inhibitory activities of β-mangostin were determined with IC 50 values of 2.17 and 27.61 µM, respectively. A strong anti-microbial activity of β-mangostin against Gram-positive strains ( Bacillus subtilis , Lactobacillus fermentum and Staphylococcus aureus ) was observed, with IC 50 values of 0.16, 0.18 and 1.24 µg ml −1 , respectively. Beta-mangostin showed weaker activity against Gram-negative strains ( Salmonella enterica , Escherichia coli and Pseudomonas aeruginosa ) as well as Candida albicans fungus, with IC 50 and MIC values greater than the tested concentration (greater than 32 µg ml −1 ). The new derivatives of β-mangostin showed weaker activities than those of β-mangostin, demonstrating the important role of the hydroxyl group at C-6 of β-mangostin in its bioactivity.

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Phenolic constituents from the tree barks of garcinia cf cymosa and their antioxidant and antibacterial activities

Cited by 2 publications

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Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei

Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei

Bioactivities of β-mangostin and its new glycoside derivatives synthesized by enzymatic reactions

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