Phenolic Constituents of Gnetum klossii

Abstract

Four new phenolic derivatives, gnetofurans A-C (1-3) and dihydropinosylvindiol (4), were isolated from a methanol-soluble extract of the stems of Gnetum klossii, together with nine known compounds [gnetifolin F (5), isorhapontigenin, gnetulin, gnetins E and C, latifolol, gnetol, (-)-epsilon-viniferin, and trans-resveratrol]. The structures of the new compounds were determined by spectral data analysis.

Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum

“…The relative stereoconfiguration of 7 was established on the basis of NOESY experiments, which displayed cross peaks between H-12 on the furan ring and H-2 /6 indicated that both protons reside on the same side. In addition, the coupling constant of 5.4 Hz between H-11 and H-12 was in agreement with the reported literature values for the relative trans-configuration [57]. The absolute configurations of C-11 and C-12 were confirmed by CD determination: a negative Cotton effect at 284 nm suggested a 11S,12R form, which is consistent with previous reports [58,59].…”

Isolation and Biomimetic Synthesis of Anti-inflammatory Stilbenolignans from Gnetum cleistostachyum

“…1. The other seven known compounds, including gnetofuran A (2), 1) gnetifolin F (4), 3) gnetumontanin C (5), 4) gnetupendin B, 5) shegansu B (6), 6) gnetol and daucosterol, 7,8) were readily identified by comparison of physical and spectroscopic data with values found in the literature.…”

“…These evidence suggested that the skeleton of 1 was similar to that of 2. 1) In the HMBC spectrum ( Fig. 2a), the significant long-range correlations between H-7b/C4a, C-5a, C-1b, C-2(6)b, C-8b, C-9b; H-8b/C-4a, C-5a, C-1b, C-7b, C-9b; H-7a/C-1a, C-2a, C-6a, C-8a indicated the planar structure of 1 as illustrated in Fig.…”

Total synthesis of natural products containing benzofuran rings

“…These kinds of naturally occurring compounds have attracted much attention from synthetic organic chemists, due to their interesting biological and pharmacological activities. [1][2][3] Several natural products bearing benzofuran and its derivatives as a moiety, [4][5][6] exhibit diverse biological activities such as being potent antibacterial, 7 antimicrobial, 8 antitumor, 9 anticonvulsant antiinammatory, 10 antidiabetic 11 and antineophobic agents.…”