Phenolic content, antioxidant and antifungal activity of jackfruit extracts (Artocarpus heterophyllus Lam.).

Chavez-Santiago, Joaquín Omar; Rodríguez-Castillejos, Guadalupe; Montenegro, Gloria; Bridi, Raquel; Valdés-Gómez, Héctor; Alvarado-Reyna, Sofía; Castillo-Ruíz, Octelina; Santiago-Adame, Rubén

doi:10.1590/fst.02221

Cited by 16 publications

(11 citation statements)

References 37 publications

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“…This study also showed the abundance of HJ leaf polyphenols in 80% HEE. Flavonoids exhibit anti-inflammatory, antioxidant, anti-angiogenic and anti-carcinogenic activities (Shi et al, 2018;Chavez-Santiago et al, 2021;Zapata et al, 2021). As presented in Table 1, HWE contained 1.10 mg QUE/g of the lowest TFC value, which is similar to the TPC values of 149.54 mg QUE/g, which is the highest TFC found in 80% of HEE, and consistent with the TPCs.…”

Section: Tpc and Tfcsupporting

confidence: 70%

Antioxidative stress effects of Humulus japonicus extracts on neuronal PC12 cells

et al. 2022

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The objective of the current study was to assess the antioxidant activity of different solvents containing Humulus japonicus extract (HJE) and their antioxidant effects on neurons. H. japonicus ethanol extracts (HEEs) together with H. japonicus water extracts (HWEs) were generated via extraction of H. japonicus leaves with 30%, 50%, and 80% ethanol solutions under a hot water temperature of 121 °C. HEEs showed higher levels of bioactive compounds, such as total flavonoids and polyphenols, with stronger antioxidant activities in contrast to HWEs. HEE (80%) showed the highest content of bioactive compounds and antioxidant activity. Next, we used a H 2 O 2 -induced rat model of pheochromocytoma PC12 cells to investigate the antioxidant activity and cellular signal regulation of 80% HEEs. The results showed that HJEs resisted oxidative stress via MAPK and/ or AKT-NRF2 and NF-kappa B signaling pathways and upregulated antioxidant enzymes such as SOD, catalase, HO-1, and OGG1, thereby reducing intracellular ROS levels. Further, HJE promoted neuronal survival by upregulating sirtuin 1 expression. This study provides evidence supporting the potential benefits of HJE in preventing oxidative stress in PC12 cells, suggesting its application as a promising functional food additive or therapeutic agent for the prevention and the treatment of oxidative stress-related neurodegenerative diseases.

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Section: Tpc and Tfcsupporting

confidence: 70%

Antioxidative stress effects of Humulus japonicus extracts on neuronal PC12 cells

et al. 2022

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“…Free radical scavenging activity is an indicator of antioxidant activity. The polyphenols and flavonoids in plants are highly reactive to free radicals, so determining the content of these compounds in selected plant extracts is also indicative of antioxidant activity (Aryal et al, 2019;Chavez-Santiago et al, 2021;Zapata et al, 2021). The TP and TF content of GRE is reflected in Table 1.…”

Section: The Total Phenolic and Flavonoid Content And And Antioxidant Activities Of Grementioning

confidence: 99%

Zingiber officinale attenuates neuroinflammation in LPS-stimulated mouse microglia by AKT/STAT3, MAPK, and NF-κB signaling

et al. 2022

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To explore the protective activity of ginger (Zingiber officinale) root ethanol extract (GRE) on the neuroinflammation induced by lipopolysaccharide in microglial cells. Ginger has been investigated as a neuroprotective and anti-aging agent. Nevertheless, ginger extract attenuates neuroinflammation in microglia have not been discovered in depth. The results showed that GRE had high total phenolic and (55.63 ± 0.16 mg GAE/g) and total flavonoid content (4.33 ± 0.17 mg QUE/g), and antioxidant activity. GRE inhibited the release of cytokines and inflammatory mediators including COX-2, PGE 2 , Nitric oxide, interleukin-6, TNF-α, and iNOS. GRE ameliorated microglia-mediated neuronal insults via upregulating the expression of Bax and reducing the expression of Bcl-2. GRE suppressed NF-κB and AKT/STAT3, and the MAPK pathway in the neuroinflammatory response. In conclusions, GRE positively affected anti-neuroinflammatory and neuroprotective activity without serious side effects, which might be used as a functional food additive and/or therapeutic material for the management and prevention of neurodegenerative diseases.

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“…[140] The Artocarpus heterophyllus extracts have a high content of polyphenols like flavonoids and these compounds were found to be have strong anti-oxidant capacity. [13] Table (2)…”

Section: Phytochemical Activitymentioning

confidence: 99%

Phytochemistry, pharmacological, medicinal significance of Artocarpus heterophyllus Lam. (Jackfruit)

Kumar¹,

Mishra²,

Singh³

2022

ijhs

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Artocarpus heterophyllus Lam. is commonly known as Jackfruit belonging to the family moraceae, is a tropical climatic fruit native to Western ghat of India and common in Asia, Africa, and some region in South America. The various parts of this tree including bark, leaves, fruits, and seeds have a wide range of medicinal properties. It is used in the numerous traditional systems of medicine to treat a vast range of diseases. Various studies have shown that jackfruits possess antioxidant, anti- inflammatory, anti-bacterial, anti-cancer activity. The phytochemical studies have found that it contains flavonoids, sterols, and prenyl flavones which contributes in various pharmacological activity. Culinary uses include jam, wine, chips, pickle and leather. Even it has several benefits, unfortunately, the fruit is underutilized at commercial scale within those regions where it is grown. This review paper contributes towards phytochemical properties, pharmacological effects, and medicinal significance of the jackfruit.

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Phenolic content, antioxidant and antifungal activity of jackfruit extracts (Artocarpus heterophyllus Lam.).

Cited by 16 publications

References 37 publications

Antioxidative stress effects of Humulus japonicus extracts on neuronal PC12 cells

Antioxidative stress effects of Humulus japonicus extracts on neuronal PC12 cells

Zingiber officinale attenuates neuroinflammation in LPS-stimulated mouse microglia by AKT/STAT3, MAPK, and NF-κB signaling

Phytochemistry, pharmacological, medicinal significance of Artocarpus heterophyllus Lam. (Jackfruit)

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