2023
DOI: 10.1002/cbdv.202301482
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Phenolic Derivatives with Anti‐Acetylcholinesterase Inhibitory Activities fromGaleola nudifoliain Vietnam

Kiep Minh Do,
Yu Nakashima,
Takeshi Kodama
et al.

Abstract: A new phenolic derivative, galeomalate A (1), together with five known structurally related compounds (2‐6), was isolated from the ethyl acetate extract of Galeola nudifolia collected in Vietnam. The structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR‐ESI‐TOF‐MS, and CD data, and chemical conversion of the sugar moiety. All isolated compounds possessed acetylcholinesterase (AChE) inhibitory activities in a dose‐dependent manner. Among them, compounds 2 and 3 exhibited the f… Show more

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