Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

Liu, W.-X.; Cui, Xiaotong; Zhong, Yifan; Ma, Ruiyang; Liu, Bo; Xia, Yuwei

doi:10.1016/j.phrs.2023.106812

Cited by 37 publications

(15 citation statements)

References 109 publications

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“…Polyphenols can transfer electrons to the free radicals and suppress them, preventing cell damage. Additionally, polyphenols activate the antioxidant enzymes and reduce oxidative stress and inflammation 51 . The anti-inflammatory effect of flavonoid derivatives (EGCG, rutin, apigenin, naringenin) and phenolic acids was demonstrated by several reports 52 .…”

Section: Resultsmentioning

confidence: 99%

Protective effect of tomato pomace extract encapsulated in combination with probiotics against indomethacin induced enterocolitis

Fouda,

Mabrouk,

Abdelgayed

et al. 2024

Sci Rep

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Tomato pomace (TP), an antioxidant-rich byproduct, may be suitable for noble applications. The regulation of ROS generation and the anti-inflammatory response can help to prevent ulceration. The purpose of this study was to examine TP for antioxidants, in silico anti-inflammatory properties, and its potential to protect against ulceration and erosion triggered by indomethacin. Tomato pomace extract (TPE) was encapsulated either alone or with probiotics to maximize its potential effect. These microcapsules were investigated in indomethacin-treated rats. TPE demonstrated antioxidant activity as well as high levels of carotenoids (15 mg/g extract) and polyphenols. Because of their binding affinity as well as hydrophobic and hydrogen bond interactions with the active sites of TNF-α and IL-1β inflammatory cytokines, ellagic acid and rutin may be implicated in the anti-inflammatory effect of TPE, according to the docking study. TPE microcapsules, either alone or in combination with probiotics, demonstrated a protective effect against enterocolitis by reducing oxidative stress and inflammation, as evidenced by the decrease in stomach and intestinal MDA, NO, IL-1β, IL-6, and TNF-α levels and the increase in CAT, SOD, and GSH activities. The produced microcapsules are suggested to be promising candidates for protection against gastric ulcers and erosion.

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Section: Resultsmentioning

confidence: 99%

Protective effect of tomato pomace extract encapsulated in combination with probiotics against indomethacin induced enterocolitis

Fouda,

Mabrouk,

Abdelgayed

et al. 2024

Sci Rep

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“…Among the molecules introduced by diet, polyphenols are the most studied compounds for their multiple biological functions. Their biological effects are mainly due to their anti-inflammatory, immunomodulatory, anti-angiogenic, neuroprotective, antioxidant and radical scavenging properties that might be beneficial for the prevention and treatment of different diseases, including breast cancer [15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of MMP-2 and MMP-9 by Dietary Antioxidants in THP-1 Macrophages and Sera from Patients with Breast Cancer

Latronico,

Petraglia,

Sileo

et al. 2024

Molecules

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Polyphenols, the main antioxidants of diet, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared the effects of four polyphenolic compounds on ROS production and on the levels of matrix metalloproteinase (MMP)-2 and -9, which represent important pathogenetic factors of breast cancer. THP-1 differentiated macrophages were activated by LPS and simultaneously treated with different doses of a green tea extract (GTE), resveratrol (RSV), curcumin (CRC) and an olive fruit extract (oliplus). By using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, we found that all of the tested compounds showed antioxidant activity in vitro. In addition, GTE, RSV and CRC were able to counteract ROS production induced by H2O2 in THP-1 cells. As assessed by a zymographic analysis of THP-1 supernatants and by an “in-gel zymography” of a pool of sera from patients with breast cancer, the antioxidant compounds used in this study inhibited both the activity and expression of MMP-2 and MMP-9 through different mechanisms related to their structures and to their ability to scavenge ROS. The results of this study suggest that the used antioxidants could be promising agents for the prevention and complementary treatment of breast cancer and other diseases in which MMPs play a pivotal role.

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“…Their effectiveness lies in their capacity to activate antioxidant enzymes, mitigating oxidative stress and inflammation ( 36 ). In addition, the phenolic metabolites can act as inhibitors or isolators of ROS while transferring electrons to free radicals, thereby promoting metabolic health ( 37 ). In this case, polyphenols in coffee could modulate metabolic pathways, contributing to the regulation of MetS characteristics (e.g., reduced serum triglycerides and FPG).…”

Section: Discussionmentioning

confidence: 99%

Moderate or greater daily coffee consumption is associated with lower incidence of metabolic syndrome in Taiwanese militaries: results from the CHIEF cohort study

Tsai,

Huang,

Sui

et al. 2023

Front. Nutr.

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BackgroundDaily moderate coffee intake was found with a lower risk of specific metabolic abnormalities, e.g., hypertension and hyperglycemia, while the association of coffee intake and incident metabolic syndrome (MetS) has not been clarified in prior studies, particularly in young adults.MethodsA total of 2,890 military personnel, aged 18–39 years, free of MetS were followed for incident MetS from baseline (2014) until the end of 2020 in Taiwan. Daily coffee amount consumed was grouped to those ≥3 cups or 600 mL (moderate or more amount) and those without. Incidence of MetS was identified in annual health examinations. MetS was diagnosed on the basis of the guideline of the International Diabetes Federation. Multivariable Cox regression model with adjustments for sex, age, body mass index, physical activity and substance use status at baseline was performed to determine the association.ResultsAt baseline, there were 145 subjects with daily coffee intake ≥3 cups or 600 mL (5.0%) in the overall cohort. During a mean follow-up of 6.0 years, 673 incident MetS (23.3%) were found. As compared to those consuming less coffee or none, those consuming daily coffee ≥3 cups had a lower risk of MetS [hazard ratio (HR): 0.69 (95% confidence interval: 0.48, 0.99)].ConclusionThis study suggests that adhering to the guideline recommended moderate or greater daily coffee consumption for promoting health, may confer advantages in preventing the development of MetS among young adults.

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Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

Cited by 37 publications

References 109 publications

Protective effect of tomato pomace extract encapsulated in combination with probiotics against indomethacin induced enterocolitis

Protective effect of tomato pomace extract encapsulated in combination with probiotics against indomethacin induced enterocolitis

Inhibition of MMP-2 and MMP-9 by Dietary Antioxidants in THP-1 Macrophages and Sera from Patients with Breast Cancer

Moderate or greater daily coffee consumption is associated with lower incidence of metabolic syndrome in Taiwanese militaries: results from the CHIEF cohort study

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