Phenolic Profile and Antioxidant Properties in Extracts of Developing Açaí (<i>Euterpe oleracea</i> Mart.) Seeds

Martins, Gabriel R.; Mattos, Mariana M. G.; Nascimento, Fabiane Marques; Brum, Felipe L.; Mohana‐Borges, Ronaldo; Figueiredo, Natália Guimarães de; Neto, Domingos F. M.; Domont, Gilberto B.; Nogueira, Fábio César Sousa; Campos, Francisco; Silva, Ayla Sant’Ana da

doi:10.1021/acs.jafc.2c07028

Cited by 12 publications

(4 citation statements)

References 52 publications

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“…Firstly, in vitro cytotoxicity of CN extract by measuring the cell viability of Hep G2 using MTT assay was evaluated. Hep G2 is a popular hepatic cell line used in a broad range of biochemical applications, including cytotoxic studies since it is widely employed as in vitro model to study liver functions 81 . Hep G2 cells were incubated with CN extract for 24 h at different concentrations (1.56–200 µg/mL) followed by morphology evaluation and determination of cell mortality.…”

Section: Resultsmentioning

confidence: 99%

Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box–Behnken design

Aquino,

Basilicata,

Crescenzi

et al. 2023

Sci Rep

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Many studies have explored the extraction of bioactive compounds from different onion solid wastes, such as bulb, skin, and peel. However, onion leaves have received limited attention despite their potential as a valuable source of nutraceutical compounds. This study aimed to valorise, for the first time, the agricultural waste in the form of spring onion leaves (CN, Cipollotto Nocerino) to obtain antioxidant-rich polyphenolic extracts. A Box–Behnken design (BBD) was used to assess the impact of microwave-assisted extraction (MAE) variables (temperature, time, extraction volume, and ethanol concentration) on total polyphenol content (TPC) measured by Folin–Ciocalteu method and the antioxidant power determined by FRAP assay. Response surface methodology (RSM) was applied, and regression equations, analysis of variance, and 3D response curves were developed. Our results highlighted that the TPC values range from 0.76 to 1.43 mg GAE g−1 dw, while the FRAP values range from 8.25 to 14.80 mmol Fe(II)E g−1 dw. The optimal extraction conditions predicted by the model were 60 °C, 22 min, ethanol concentration 51% (v/v), and solvent volume 11 mL. These conditions resulted in TPC and FRAP values of 1.35 mg GAE g−1 dw and 14.02 mmol Fe(II)E g−1 dw, respectively. Furthermore, the extract obtained under optimized conditions was characterized by UHPLC-ESI-Orbitrap-MS analysis. LC/MS–MS platform allowed us to tentatively identify various compounds belonging to the class of flavonoids, saponins, fatty acids, and lipids. Finally, the ability of CN optimal extract to inhibit the intracellular reactive oxygen species (ROS) release in a hepatocarcinoma cell line using an H2O2-induced oxidative stress model, was evaluated. The results highlighted the potential of CN extract as a valuable source of polyphenols with significant antioxidant properties, suitable for various applications in the food and pharmaceutical industries.

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Section: Resultsmentioning

confidence: 99%

Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box–Behnken design

Aquino,

Basilicata,

Crescenzi

et al. 2023

Sci Rep

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“…Oxidative stress, inflammation, and the renin-angiotensin system (RAS) contribute to the development of hypertension [ 118 ]. The use of açaí seed extract can exhibit antihypertensive effects in mice fed a high-fat diet, as shown by Santos et al [ 164 , 165 , 166 ]. In this study, animals were treated with açaí seed extract (300 mg/kg per day) and enalapril, a common antihypertensive drug.…”

Section: Biological and Pharmacological Effectsmentioning

confidence: 97%

“…Despite the multifactorial onset and progression of NAFLD, specific intracellular contributory factors, such as inflammation, oxidative stress, mitochondrial dysfunction, altered endoplasmic reticulum (ER) homeostasis, and apoptosis, have been identified [ 115 ]. Therefore, the phenolic compounds of açaí are regarded as prospective therapeutic agents in the treatment of NAFLD due to their high antioxidant and anti-inflammatory capacities [ 47 , 163 , 164 , 165 ]. Freitas et al [ 115 ] tested the actions of an aqueous açaí extract in HepG2 cells and its effects on inflammation, oxidative stress, and ER stress.…”

Section: Biological and Pharmacological Effectsmentioning

confidence: 99%

Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review

et al. 2023

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The açaí palm (Euterpe oleracea Mart.), a species belonging to the Arecaceae family, has been cultivated for thousands of years in tropical Central and South America as a multipurpose dietary plant. The recent introduction of açaí fruit and its nutritional and healing qualities to regions outside its origin has rapidly expanded global demand for açaí berry. The health-promoting and disease-preventing properties of this plant are attributed to numerous bioactive phenolic compounds present in the leaf, pulp, fruit, skin, and seeds. The purpose of this review is to present an up-to-date, comprehensive, and critical evaluation of the health benefits of açaí and its phytochemicals with a special focus on cellular and molecular mechanisms of action. In vitro and in vivo studies showed that açaí possesses antioxidant and anti-inflammatory properties and exerts cardioprotective, gastroprotective, hepatoprotective, neuroprotective, renoprotective, antilipidemic, antidiabetic, and antineoplastic activities. Moreover, clinical trials have suggested that açaí can protect against metabolic stress induced by oxidation, inflammation, vascular abnormalities, and physical exertion. Due to its medicinal properties and the absence of undesirable effects, açaí shows a promising future in health promotion and disease prevention, in addition to a vast economic potential in the food and cosmetic industries.

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“…Roots can be used as herbal medicine and tonic [10]. It is beneficial for health promotion and disease prevention because it contains antioxidant and anti-inflammatory properties and exerts cardioprotective, gastroprotective, hepatoprotective, neuro-protective, reno-protective, antilipidemic, antidiabetic, and antineoplastic activities [8,18].…”

Section: Prospects and Challenges Of Açai Domestication In Indonesiamentioning

confidence: 99%

Domestication of Euterpe oleracea (Arecaceae) to provide food from peatlands

Tata,

Rachmanadi,

Suwarno

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Euterpe oleracea (Arecaceae), which is known as Acai, is a palm tree originating from swampy forest of Suriname. Acai is naturally distributed in swampy, sandy soil, river edges and seasonally flooded habitats; hence it is considered as paludiculture species. Acai’s domestication study in Indonesia is limited, therefore our study aimed to assess morphology and germination of Acai’s seeds in the nursery, and early growth performance in the field. Acai’s seed diameter was ranging from 0.88±0.01 cm; seed wet weight was 1.19±0.31 g. Acai seeds germinated for up to 5-7 months. Soaked seeds in warm water overnight had 8.33% germination rate, while soaked seeds in tap water overnight had lesser germination rates (1.75%). After one year transplanted to a peat swamp forest ecosystem of Tumbang Nusa, Central Kalimantan, Acai’s seedlings had 100% survival rate. The relative growth rate of height and diameter of Acai seedlings were 4.21 cm month−1 and 0.08 cm month−1, respectively. Acai seedlings survived floodings that occurred in November 2021 to March 2022. The water level was around -35.6 to 17.7 cm. Despite of some challenging, açai is a promising species to be domesticated on degraded peatlands.

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Phenolic Profile and Antioxidant Properties in Extracts of Developing Açaí (Euterpe oleracea Mart.) Seeds

Cited by 12 publications

References 52 publications

Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box–Behnken design

Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box–Behnken design

Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review

Domestication of Euterpe oleracea (Arecaceae) to provide food from peatlands

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