Phenolic profiles and antioxidant and anticarcinogenic activities of Greek herbal infusions; balancing delight and chemoprevention?

Kaliora, Andriana C.; Kogiannou, Dimitra; Kefalas, Panagiotis; Papassideri, Issidora S.; Kalogeropoulos, Nick

doi:10.1016/j.foodchem.2013.07.056

Cited by 69 publications

(59 citation statements)

References 40 publications

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“…Gallic acid was detected in lemon balm in accordance to previous studies (Arceusz and Wesolowski, 2013;Pereira et al, 2014) and also in hyssop, oregano and sage. In accordance to previous studies, chlorogenic acid was detected in hyssop (Dzamic et al, 2013;Hatipoglu et al, 2013), lemon balm (Arceusz and Wesolowski, 2013;Pereira et al, 2014), dittany (Kaliora et al, 2014) and sage (Roby et al, 2013;Zimmermann et al, 2011). Ferrulic acid was detected in hyssop (Dzamic et al, 2013), lemon balm (Arceusz and Wesolowski, 2013), dittany (Proestos et al, 2006;2008) and oregano (Agiomyrgianaki & Dais 2012).…”

Section: Hplc Analysissupporting

confidence: 89%

“…Rosmarinic acid has already been reported to be present in hyssop (Dzamic et al, 2013), lemon balm (Arceusz and Wesolowski, 2013;Barros et al, 2013;Carnat et al, 1998;Dastmalchi et al, 2008), dittany (Liolios et al, 2010;Kaliora et al, 2014;Kouri et al, 2007), oregano (Agiomyrgianaki & Dais 2012;Martins et al 2014;Shen et al, 2010) and salvia (Cvetkovikj et al, 2013;Kaliora et al, 2014;Martins et al, 2015;Roby et al, 2013;Zimmermann et al, 2011). All plant extracts were analyzed at the same concentration of dry plant mass, so their relevant concentration of rosmarinic acid is presented in Table 2 as the area of corresponding peaks in chromatograms.…”

Section: Hplc Analysismentioning

confidence: 99%

“…The chemical composition of the essential oils, phenolic compounds and flavonoids has been previously studied either for evaluation of aromatic properties or the antioxidant and biological activity (Castilho et al, 2012;Dzamic et al, 2013;Kaliora et al, 2014;Licina et al, 2013;Martins et al, 2014Martins et al, , 2015. Skotti, et al: Bioactivity of Greek MAP extracts on Alternaria…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biological activity of selected Greek medicinal and aromatic plants extracts on Alternaria alternata

Tarantilis¹,

Skotti²,

Kountouri³

et al. 2016

Emir. J. Food Agric

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In this study, the biological activity of selected Greek medicinal and aromatic plants on the phytopathogenic fungus Alternaria alternata was investigated. Biological activity was screened on crude aqueous extracts and their aqueous phase (ap-pt) after further extraction with petroleum ether. All the Lamiaceae species examined were found to enhance significantly the mycelium growth. Melissa officinalis extracts caused the highest stimulation in mycelium growth, (+109.1%) the ap-pt, and (+51.6%) its crude extract. All ap-pt extracts stimulated conidia production, but Melissa officinalis caused the highest effect (+349.3%). Crude extracts of Salvia officinalis stimulated highly conidial production (+65%) whereas Hyssopus. officinalis and Origanum vulgare inhibited conidia production at 33.3% and 50.0% respectively. The differences in biological activity between crude and ap-pt extracts for each plant species were attributed through the calculation of correspondent synergism ratios (SR) to the interaction between volatile and water -soluble. Rosmarinic acid, detected as the most abundant phenolic compound in all extracts analyzed and found to correlate strongly (R= 0.84) with the stimulation effect on spore production of A. alternata.

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Section: Hplc Analysissupporting

confidence: 89%

Section: Hplc Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biological activity of selected Greek medicinal and aromatic plants extracts on Alternaria alternata

Tarantilis¹,

Skotti²,

Kountouri³

et al. 2016

Emir. J. Food Agric

View full text Add to dashboard Cite

show abstract

“…Chemical analysis using GC-MS revealed compounds like β-caryophyllene, α-caryophyllene, eucalyptol, α-thujone, β-thujone, viridiflorol, mannol, camphor and luteolin-7-O-glucoronide in the ExtHS, that are known to present antioxidant, bactericidal, anti-inflammatory and analgesic activity (Fischedick et al 2013, Kaliora et al 2014. β-caryophyllene has been atribuited to inhibit growth of cell lines and induce apoptosis in limphoma and neuroblastoma, through ROSmediated and cascade of mitogen-activated protein kinases (MAPKs) inhibition (Park et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Garcia

Menti

Lambert

et al. 2016

An. Acad. Bras. Ciênc.

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Salvia offi cinalis (Lamiaceae) has been used in south of Brazil as a diary homemade, in food condiment and tea-beverage used for the treatment of several disorders. The objective of this study was to characterize chemical compounds in the hydroalcoholic (ExtHS) and aqueous (ExtAS) extract from Salvia offi cinalis (L.) by gas chromatography-mass spectrometry (GC-MS) and by high-resolution electrospray ionization mass spectrometry (ESI-QTOF MS/MS), evaluate in vitro ability to scavenge the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH • ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS •+ ), catalase (CAT-like) and superoxide dismutase (SOD-like) activity, moreover cytotoxic by MTT assay, alterations on cell morphology by giemsa and apoptotic-induced mechanism for annexin V/propidium iodide. Chemical identifi cation sage extracts revealed the presence of acids and phenolic compounds. In vitro antioxidant analysis for both extracts indicated promising activities. The cytotoxic assays using tumor (Hep-2, HeLa, A-549, HT-29 and A-375) and in non-tumor (HEK-293 and MRC-5), showed selectivity for tumor cell lines. Immunocytochemistry presenting a majority of tumor cells at late stages of the apoptotic process and necrosis. Given the results presented here, Brazilian Salvia offi cinalis (L.) used as condiment and tea, may protect the body against some disease, in particularly those where oxidative stress is involved, like neurodegenerative disorders, infl ammation and cancer.

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“…This led some authors to the opinion that dietary phenols have lower importance and antioxidant effect in vivo than is generally thought (Olthof and others ). On the other hand, there is evidence of antioxidant and/or antimutagenic activity of plant extracts or herbal infusions connected with high concentration of phenolics including hydroxyphenylacetic and dihydroxyphenylactic acid (Kogiannou and others ; Kaliora and others ), but they do not show the contribution of these simple phenolics on the total effect. Antiradical activity of dihydroxyphenylacetic acid was further proved using DPPH • and peroxyl scavenging activity (LeBlanc and others ) and also some other methods (Rubio‐Senent and others ).…”

Section: Flavonoidsmentioning

confidence: 99%

Flavonoids as Potent Scavengers of Hydroxyl Radicals

Treml

Šmejkal

2016

Comp Rev Food Sci Food Safe

339

166

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Oxidative stress is a fundamental principle in the pathophysiology of many diseases. It occurs when the production of reactive oxygen species exceeds the capacity of the cell defense system. The hydroxyl radical is a reactive oxygen species that is commonly formed in vivo and can cause serious damage to biomolecules, such as lipids, proteins, and nucleic acids. It plays a role in inflammation-related diseases, like chronic inflammation, neurodegeneration, and cancer. To overcome excessive oxidative stress and thus to prevent or stop the progression of diseases connected to it, scientists try to combat oxidative stress and to find antioxidant molecules, including those that scavenge hydroxyl radical or diminish its production in inflamed tissues. This article reviews various methods of hydroxyl radical production and scavenging. Further, flavonoids, as natural plant antioxidants and essential component of the human diet, are reviewed as compounds interacting with the production of hydroxyl radicals. The relationship between hydroxyl radical scavenging and the structure of the flavonoids is discussed. The structural elements of the flavonoid molecule most important for hydroxyl radical scavenging are hydroxylation of ring B and a C2-C3 double bond connected with a C-3 hydroxyl group and a C-4 carbonyl group. Hydroxylation of ring A also enhances the activity, as does the presence of gallate and galactouronate moieties as substituents on the flavonoid skeleton.

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Phenolic profiles and antioxidant and anticarcinogenic activities of Greek herbal infusions; balancing delight and chemoprevention?

Cited by 69 publications

References 40 publications

Biological activity of selected Greek medicinal and aromatic plants extracts on Alternaria alternata

Biological activity of selected Greek medicinal and aromatic plants extracts on Alternaria alternata

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Flavonoids as Potent Scavengers of Hydroxyl Radicals

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