Phenolic-Rich Extract from Almond (Prunus dulcis ) Hulls Improves Lipid Metabolism in Triton WR-1339 and High-Fat Diet-Induced Hyperlipidemic Mice and Prevents Lipoprotein Oxidation: A Comparison with Fenofibrate and Butylated Hydroxyanisole

Harnafi, M.; Bekkouch, Oussama; Touiss, Ilham; Khatib, Saloua; Mokhtari, Imane; Milenković, Dragan; Harnafi, Hicham; Amrani, Souliman

doi:10.3746/pnf.2020.25.3.254

Cited by 11 publications

(6 citation statements)

References 27 publications

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“…The ZLF extract significantly decreased the total cholesterol/HDL-cholesterol ratio in fat-overloaded mice, confirming that this extract has a beneficial effect on lipid profile regulation and ultimately prevents cardiovascular disease. This is consistent with other work examining the anti-hyperlipidemia effects of plant extracts [34,35,44,45].…”

Section: The Effect Of Zlf On Hdl Cholesterol/total Cholesterol and Atherogenic Indexsupporting

confidence: 92%

“…This suggests that the hypocholesterolemic activity of the aqueous ZLF extract may be due to the redistribution of plasma LDL-cholesterol to the liver and extra-hepatic tissues via these receptors at the level of hepatocytes, intended for elimination in the form of bile acids. In addition, to avoid cholesterol deposition in blood vessels, the abundance of cholesterol in peripheral tissues must be returned to the liver via HDL [35]. Indeed, the hypocholesterolemic property of the aqueous ZLF extract has been associated with a rise in plasma levels of HDL-cholesterol, leading to the elimination of cholesterol in the form of bile acids.…”

Section: β-Carotene Bleaching Testmentioning

confidence: 99%

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Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

et al. 2021

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Ziziphus lotus (L.) Lam. (Z. lotus) is a medicinal plant species that is widely distributed throughout the Mediterranean basin. Moroccans traditionally use it to treat many illnesses thanks to its beneficial medicinal properties. The purpose of this study is to assess the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Z. lotus fruits (ZLF). The 2-2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the β-carotene bleaching test were used to determine the antioxidant activity of ZLF. The anti-hyperlipidemic effect of the aqueous extract of ZLF (200 and 400 mg/kg) was evaluated in albino mice exposed to the chronic high-fat diet, based on lipid profile, blood sugar, and changes in growth performance. The results showed that the aqueous extract of ZLF rich in flavonoids (2242.89 ± 25 µg QE (quercitin equivalent)/mg), and has a considerable antioxidant power against DPPH radicals (IC50 = 116 ± 0.02 µg/mL) and β-carotene oxidation. The aqueous extract of ZLF also showed a significant anti-hyperlipidemic effect by improving abnormal changes in lipid profile and blood glucose levels in albino mice exposed to a chronic high-fat diet. Our findings suggest that the anti-hyperlipidemic activities of ZLF aqueous extract are correlated with its flavonoid content and antioxidant activity. Therefore, the aqueous extract of ZLF could be an essential therapeutic candidate for hyperlipidemia patients, thanks to its richness in bioactive molecules.

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Section: The Effect Of Zlf On Hdl Cholesterol/total Cholesterol and Atherogenic Indexsupporting

confidence: 92%

Section: β-Carotene Bleaching Testmentioning

confidence: 99%

Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

et al. 2021

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“…TC, TG, and HDL‐C concentrations in serum were determined by enzymatic colorimetric methods employing commercial kits available. LDL‐C was calculated as follows [ 36,37 ] :…”

Section: Methodsmentioning

confidence: 99%

Walnut fruit diaphragm ethanol extract ameliorates damage due to Triton WR‐1339‐induced hyperlipidemia in rats

Palabiyik,

Sulumer,

Uguz

et al. 2023

Euro J Lipid Sci & Tech

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The walnut fruit diaphragm (WFD) is an economically and ecologically important by‐product of the Juglandaceae family. Components in the ethanolic extract of WFD (E‐WFD) were identified by gas chromatography‐mass spectroscopy (GC‐MS). In our study, the lipid‐lowering effect, antioxidant potential, and anti‐inflammatory properties of E‐WFD in the blood, heart, and liver tissues of rats (♂, Wistar) with hyperlipidemia caused by Triton WR‐1339 were determined using biochemical, histopathological, and molecular techniques. Experimental animals for analysis are as follows: K1: healthy control group, K2: E‐WFD (150 mg, o.d.), K3: E‐WFD (300 mg, o.d.), K4: HL (hyperlipidemic group) (400 mg kg–1 Triton WR‐1339, i.p.), K5: HL + E‐WFD (300 mg) grouped as (n = 6). After the application, anti‐hyperlipidemic analysis (TC, TG, LDL‐C, HDL‐C, ALT, and AST), oxidative stress (MDA, SOD, and CAT) parameters measurement, histopathological examinations, and inflammatory biomarker genes (Tnf‐α, Il‐6, Il‐1β, Mmp‐2, Mmp‐9, Lxr‐α and Srebp‐1c) expression stability were determined by q‐RT PCR. With the E‐WFD application, there was a decrease in TC and TG levels and an increase in HDL‐C. Oxidative stress decreased by changing MDA, SOD, and CAT levels. Histopathological deterioration in the tissues changed positively. In addition, E‐WFD showed significant inhibitory properties on Tnf‐α, Il‐6, Il‐1β, Mmp‐2, Mmp‐9, Lxr‐α, and Srebp‐1c genes.Practical applications: It is known that hyperlipidemia causes a wide range of diseases. In this study, the effect of walnut fruit diaphragm (WFD) ethanol extract was compared against the effect of Triton WR‐1339‐induced hyperlipidemia on rats. With the use of WFD, the damages caused by hyperlipidemia were significantly ameliorated. Accordingly, it is expected to contribute to the pharmacology, food and cosmetic industries as a very valuable alternative product.]

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“…The aluminium chloride reagent was used to assess flavonoids [15]. Five-millilitre samples were mixed with 2.5 ml of AlCl3.…”

Section: Estimation Of Flavonoid Content In the Rae And Caementioning

confidence: 99%

The synergistic effect of the combination of Ocimum basilicum and Ceratonia siliqua on inflammation and oxidative stress

Touiss,

Khaili,

Khouya

et al. 2024

E3S Web Conf.

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The use of basil and carob in traditional medicine to address inflammation and oxidative stress reflects a long-standing practice rooted in folk medicine. This study was conducted to demonstrate the anti-inflammatory and antioxidant properties of a rosmarinic acid-rich extract of Ocimum basilicum (RAE) combined with a carob aqueous extract (CAE). Paw edema in rats and vascular permeability in mice were measured to investigate the anti-inflammatory effect. The assessment of lipoprotein oxidation was carried out by measuring thiobarbituric acid reactive substances as well as determining the scavenging activity towards lipoperoxyl radicals and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The combination (200 mg/kg) significantly decreased carrageenan-induced rat paw edema and vascular permeability in mice (p<0.001), and these effects were comparable to those of the indomethacin drug (50 mg/kg). Moreover, the combination significantly prevented plasma lipoprotein oxidation and efficiently scavenged lipoperoxyl (IC50= 160 ± 11 μg/ml) and DPPH (IC50= 80 ± 4 μg/ml) radicals. The present study indicates the potential nutraceutical benefits of combining Basil and Carob in the treatment of inflammatory and oxidative stress-related diseases, which is correlated with the high contents of rosmarinic acid, phenolic acids, and fibres.

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Phenolic-Rich Extract from Almond (Prunus dulcis ) Hulls Improves Lipid Metabolism in Triton WR-1339 and High-Fat Diet-Induced Hyperlipidemic Mice and Prevents Lipoprotein Oxidation: A Comparison with Fenofibrate and Butylated Hydroxyanisole

Cited by 11 publications

References 27 publications

Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

Walnut fruit diaphragm ethanol extract ameliorates damage due to Triton WR‐1339‐induced hyperlipidemia in rats

The synergistic effect of the combination of Ocimum basilicum and Ceratonia siliqua on inflammation and oxidative stress

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