Tannins are polyphenolic substances found in plants with biological and technological importance. An experiment using response surface methodology was carried out aiming to optimize tannin extraction from cashew tree bark by studying the influence of some critical variables (time, temperature, and liquid/solid ratio) on the aqueous extraction by dynamic maceration of phenolics and condensed tannins (CT). The effect of reusing bark and solvent in CT extraction was evaluated, as well as the effect of extract drying using spray and freeze-drying. By assessing the relations of independent variables time, temperature, and liquid/solid (L/S) ratio, the condition that yielded the highest tannin content was 100°C for 100 min with a L/S ratio of 30:1. Under these conditions, the CT yielded was 7.63 mg/100 mg bark. Using the same solvent in up to two extractions was viable to extract CT, and spray-drying was the most appropriate drying method for industrial application compared with freeze-drying.