Phenolics from Archidendron clypearia (Jack) I.C.Nielsen protect SH-SY5Y cells against H2O2-induced oxidative stress

Wang, Yuxi; Feng-ying, Han; Duan, Zhi-Kang; Chang, Ye; Lin, Bin; Wang, Xiaobo; Huang, Xiao‐Xiao; Yao, Guo-Dong; Song, Shao‐Jiang

doi:10.1016/j.phytochem.2020.112414

Cited by 16 publications

(10 citation statements)

References 32 publications

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“…Oxidative stress induced by H 2 O 2 is a key factor influencing SH‐SY5Y cell death (Wang et al ., 2020). The results of the present study showed that PPL‐1 (concentration, 500 µg mL −1 ) did not significantly influence cell viability in cultured SH‐SY5Y cells.…”

Section: Resultsmentioning

confidence: 99%

Purification, characterisation and antioxidant properties of a novel polysaccharide from Physalis pubescens L. fruits

Gao

Zhang

Wang

et al. 2022

Int J of Food Sci Tech

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Considering the medicinal and edible properties of Physalis pubescens L. fruit, the plant has a long history of cultivation in China. In the current study, a novel polysaccharide (PPL-1) was successfully obtained from P. pubescens fruits using multi-column techniques. The chemical characterisation of the polysaccharide was achieved by acid hydrolysis, determination of weight average molecular mass, thermogravimetric and Smith degradation analyses, in addition to ultraviolet, Fourier transform infrared spectroscopy, oneand two-dimensional nuclear magnetic resonance spectroscopy. According to the structural analyses, PPL-1 consisted of rhamnose, arabinose, fructose, mannose and glucose with a relative molar ratio of 0.39:0.12:0.02:0.03:0.44. The average molecular weight of PPL-1 was 7.3 kDa and it was mainly composed of (1 → 3) and (1 → 6) linkages. PPL-1 exhibited not only scavenging effects on 2,2-diphenyl-1picrylhydrazyl and 2,2 0 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) free radicals but also hydrogen peroxide-induced oxidative stress in SH-SY5Y cells effectively by decreasing malondialdehyde content and increasing total antioxidant capacity, superoxide dismutase and glutathione peroxidase activity levels.

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Section: Resultsmentioning

confidence: 99%

Purification, characterisation and antioxidant properties of a novel polysaccharide from Physalis pubescens L. fruits

Gao

Zhang

Wang

et al. 2022

Int J of Food Sci Tech

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“…However, the 1D NMR data around C‐2 of 3 and 2 had no obvious difference (Δ δ C <1 ppm, Δ δ H <0.1 ppm, Table 1). The structures of the C‐2 epimers ( 2 and 3 ) were consecutively optimized at PM6, HF/6‐31G(d), and B3LYP/6‐311++G(2d,p) level in chloroform simulated by the IEFPCM model [21] . The optimized structures of 2 (blue) and 3 (green) were depicted in Figure 4, from which could be observed that the shielding effects of C‐2 phenyl moieties on the atoms around C‐2 in 2 and 3 were nearly identical.…”

Section: Resultsmentioning

confidence: 99%

“…The conformational search and ECD calculations of the isolates 1 – 3 were carried out according to a published procedure [21] …”

Section: Methodsmentioning

confidence: 99%

“…The structures of the C-2 epimers (2 and 3) were consecutively optimized at PM6, HF/6-31G(d), and B3LYP/6-311 + + G(2d,p) level in chloroform simulated by the IEFPCM model. [21] The optimized structures of 2 (blue) and 3 (green) were depicted in Figure 4, from which could be observed that the shielding effects of C-2 phenyl moieties on the atoms around C-2 in 2 and 3 were nearly identical. This observation explained the similarity of the 1D NMR spectroscopic data of compounds 3 and 2.…”

Section: 'mentioning

confidence: 99%

“…The conformational search and ECD calculations of the isolates 1-3 were carried out according to a published procedure. [21] Luo. All authors discussed and agreed with the results of this manuscript.…”

Section: Computational Detailsmentioning

confidence: 99%

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Cajuputones A–C, β‐Triketone Flavanone Hybrids from the Branches and Leaves of Melaleuca cajuputi

Xie

et al. 2020

Chemistry & Biodiversity

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Three new β-triketone flavanone hybrids, cajuputones A-C were obtained from Melaleuca cajuputi (the Australian 'tea tree'). The structures of cajuputones A-C were elucidated by 1D/2D NMR spectroscopy and HR-ESI-MS analyses; and their absolute configurations were established by electric circular dichroism (ECD) calculations using TDDFT method. Structurally, cajuputones A-C feature a rare 6/6/6/6 oxatetracyclic ring system fused between an acylphloroglucinol-derived β-triketone and a pinocembrin or strobopinin moiety via an angletype pyran-like motif. DFT-based conformational optimization in chloroform explained the similarity of the 1D NMR data of cajuputones B and C (C-2 epimers).

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Four Pairs of Neuroprotective Aryldihydronaphthalene‐Type Lignanamide Enantiomers from the Herbs of Solanum lyratum

Mi,

Chang,

Zhang

et al. 2023

Chemistry & Biodiversity

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Four pairs of aryldihydronapthalene‐type lignanamide enantiomers were isolated from Solanum lyratum (Solanaceae). The enantiomeric separation was accomplished by chiral‐phase HPLC, and five undescribed compounds were elucidated. Analysis by various spectroscopy and ECD calculations, the structures of undescribed compounds were illuminated. The neuroprotective effects of all compounds were evaluated using H2O2‐induced human neuroblastoma SH‐SY5Y cells and AchE inhibition activity. Among them, compound 4a exhibited remarkable neuroprotective effects at high concentrations of 25 and 50 μmol/L comparable to Trolox. Compound 1a showed the highest AchE inhibition with the IC50 value of 3.06 ± 2.40 μmol/L. Molecular docking of the three active compounds was performed and the linkage between the compounds and the active site of AchE was elucidated.

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Phenolics from Archidendron clypearia (Jack) I.C.Nielsen protect SH-SY5Y cells against H2O2-induced oxidative stress

Cited by 16 publications

References 32 publications

Purification, characterisation and antioxidant properties of a novel polysaccharide from Physalis pubescens L. fruits

Purification, characterisation and antioxidant properties of a novel polysaccharide from Physalis pubescens L. fruits

Cajuputones A–C, β‐Triketone Flavanone Hybrids from the Branches and Leaves of Melaleuca cajuputi

Four Pairs of Neuroprotective Aryldihydronaphthalene‐Type Lignanamide Enantiomers from the Herbs of Solanum lyratum

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