Phenomena of the Hypokinetic Rigid Type caused by O-methylation of Dopamine in the Para-position

Ernst, A. M.

doi:10.1038/193178b0

Cited by 63 publications

(3 citation statements)

References 3 publications

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“…However, these pathways have not been proved yet in mammalian tissues; therefore, they remain as possibilities. Nonetheless, it is interesting to note that Ernst (1962) produced an akineto-rigid syndrome in cats with injections of DMPEA, and Banbeau et a!.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dopamine, Dimethoxyphenylethylamine, Papaverine, and Related Compounds on Mitochondrial Respiration and Complex I Activity

Morikawa

Nakagawa‐Hattori

Mizuno

1996

Journal of Neurochemistry

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We report the effect of papaverine, tetrahydropapaverine, laudanosine, dimethoxyphenylethylamine, dopamine, and its metabolites on mitochondrial respiration and activities of the enzymes in the electron transfer complexes, as mitochondrial toxins may be implicated in the etiology and the pathogenesis of Parkinson's disease. Papaverine was the most potent inhibitor of complex I and NADH‐linked mitochondrial respiration among the compounds tested next to rotenone. Tetrahydropapaverine, dimethoxyphenylethylamine, and laudanosine also inhibited NADH‐linked mitochondrial respiration and complex I activity in this order. Dopamine and its metabolites showed either no inhibition or only very weak inhibition. Compounds with dimethoxy residues in the phenyl ring were associated with more potent inhibition of complex I than those without. Our results warrant further studies on these and some related compounds as candidate neurotoxins causing Parkinson's disease.

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Section: Discussionmentioning

confidence: 99%

“…(1966) produced rigid-akinetic states in rats, rabbits, and monkeys by systemic administration of DMPEA; however, no nigral cell death was observed. Furthermore, Ernst (1962) observed that !audanine, a compound structurally related to laudanosine, provoked a .1. Neurochem., Vol.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dopamine, Dimethoxyphenylethylamine, Papaverine, and Related Compounds on Mitochondrial Respiration and Complex I Activity

Morikawa

Nakagawa‐Hattori

Mizuno

1996

Journal of Neurochemistry

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“…Although neither PMPEA nor DMPEA appear to have much effect when injected intravenously in human volunteers (Hollister & Friedhoff, 1966;Brown, McGeer & Moser, 1968), they do produce marked behavioural changes in animal subjects (Epstein et al, 1932;Ernst, 1962). Evidently, continued study of these and related compounds may be important for the understanding of central nervous system changes induced by drugs or by disease.…”

Section: Action Of Blocking Agentsmentioning

confidence: 99%

The action of para‐methoxyphenylethylamine (PMPEA) on monosynaptic reflex transmission in the cat

Walker

Willis

1970

British J Pharmacology

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Summary1. The intravenous injection of para-methoxyphenylethylamine (PMPEA) into cats produces an increase in the size of the spinal cord monosynaptic reflex. The reflex elevation occurs within 30 s of drug administration, reaches a peak within 2 min, and lasts about 20 min. 2. The action of PMPEA is similar for extensor (gastrocnemius-soleus) and flexor (posterior biceps-semitendinosus) monosynaptic reflexes. 3. Repeated doses of PMPEA give comparable effects. The degree of monosynaptic reflex elevation is dose related. 4 The action of PMPEA is antagonized by phenoxybenzamine and by methysergide or cyproheptadine. The combination of phenoxybenzamine with either of the latter is particularly effective in preventing the reflex facilitation by PMPEA. 5. It is concluded that PMPEA has a central action on the spinal cord. It seems likely that monoaminergic synapses are involved.

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The Biochemistry of the Functional Psychoses

Weil‐Malherbe

1967

Advances in Enzymology - And Related Areas of Molecular Biology

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Phenomena of the Hypokinetic Rigid Type caused by O-methylation of Dopamine in the Para-position

Cited by 63 publications

References 3 publications

Effect of Dopamine, Dimethoxyphenylethylamine, Papaverine, and Related Compounds on Mitochondrial Respiration and Complex I Activity

Effect of Dopamine, Dimethoxyphenylethylamine, Papaverine, and Related Compounds on Mitochondrial Respiration and Complex I Activity

The action of para‐methoxyphenylethylamine (PMPEA) on monosynaptic reflex transmission in the cat

The Biochemistry of the Functional Psychoses

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