The intrinsic characteristic of material substances is their ability to modify their physical state and their energy content in response to the interactions and stresses they receive. And it is the capacity that crosses transversely all living matter including man, with the difference that the man solicited by external events becomes aware of his own uniqueness and his own destiny. We can say that man acquires human characters when he learns to re-know his fellow men and the world around him and experiences the wonder that this experience transmits him. And we will show how the whole of the multiplication of contacts and interactions between men produces the corpus of knowledge of peoples. Starting from this hypothesis, in this work we are going to describe how the transformations produced by the reciprocal interactions between material substances, and between these and their environment, are acquired in the form of knowledge. The analysis of the events we describe of the cognitive process follows the logical procedure, which will lead us to the conclusion that knowledge is the intrinsic manifestation of matter and how it originates and takes shape from it. With the advent of man, the highest expression of the organization of matter and knowledge, matter itself embodied in man can investigate knowing itself and its intimate essence. Thus, knowledge can be conceived as the virtuous ontological circuit that originates from matter and returns to it modified in form and enriched with content.