Phenomenon of atypical vascular effects of epinephrine and an increase of photodynamic response by nitroglycerin in rats with colon adenocarcinoma: adrenergic and nitrergic mechanisms and novel applied aspects

Abstract

Using an original model of stress-induced colon adenocarcinoma, we uncover atypical vasorelaxation effects of a mucosa injection of epinephrine assessed by laser speckle contrast imaging and a significant increase of fluorescent intensity of 5-ALA/PpIX from malignant colon tissues by a mucosa injection of nitroglycerine. We clearly demonstrate a high activity of adrenergic and nitrergic mechanisms underlying this phenomenon and discuss their application in improving of optical approaches for effective diagnosis of gastrointestinal cancer.

A review of career devoted to Biophotonics – In memoriam to Ekaterina Borisova (1978–2021)

“…Prof. Ekaterina Borisova also worked on photodiagnosis and photodynamic therapy of gastrointestinal tract. Her work included the investigation of novel photosensitizers and the optimal parameters for their irradiation and photodynamic activation [48][49][50][51][52][53][54][55][56][57]. As a result, significant amount of her work was dedicated to the photodynamic diagnosis [48,58], photodynamic efficacy [59] and therapy as well [60][61][62][63].…”