Phenothiazine appended thiophene derivative: a trilateral approach to copper ion detection in living cells and aqueous samples

Ilakiyalakshmi, Mohan; Napoleon, Ayyakannu Arumugam

doi:10.1039/d3ra07608c

RSC Adv.

2024

DOI: 10.1039/d3ra07608c

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Phenothiazine appended thiophene derivative: a trilateral approach to copper ion detection in living cells and aqueous samples

Mohan Ilakiyalakshmi,

Ayyakannu Arumugam Napoleon

Abstract: A novel phenothiazine-thiophene acetonitrile compound was synthesised through a Knoevenagel condensation reaction. The compound demonstrated selectivity towards Cu2+ and proved to have low cytotoxicity.

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Cited by 3 publications

References 51 publications

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Thiazole-derived pyrazin-2-carbohydrazide chemosensors: Colorimetric & photoluminescent detection of silver ions for theoretical, environmental, and cell imaging

Dhanasekaran,

Ilakiyalakshmi,

Mohandoss

et al. 2025

Journal of Photochemistry and Photobiology A: Chemistry

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Thiazole-derived pyrazin-2-carbohydrazide chemosensors: Colorimetric & photoluminescent detection of silver ions for theoretical, environmental, and cell imaging

Dhanasekaran,

Ilakiyalakshmi,

Mohandoss

et al. 2025

Journal of Photochemistry and Photobiology A: Chemistry

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4-Diphenylaminobenzaldehyde-formulated isonicotinohydrazide for the rapid recognition of Cu2+ ions; Application of RGB tool, pharmaceutical samples, and DFT studies

Dhanasekaran,

Mohandoss,

Napoleon

2025

Journal of Molecular Structure

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An activatable NIR turn-on fluorescent probe for copper (II) ion and live cell imaging

Ahmed,

Liu,

et al. 2024

Sci Rep

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Herein we have reported a fluorescent probe (MB-M) based on MB derivative for Cu 2+ ions detection. The probe was well characterized by 1 H NMR, 13 C NMR and HR-MS spectrum. Probe MB-M showed naked-eyes recognition to Cu 2+ as color change from colorless to indigo. The probe exhibited promising features such as high fluorescence and UV–vis selectivity, fast response (5 mint), workable at pH 2–7, and low limit of detection (LOD = 0.33 µM). Probe MB-M was also used for Cu 2+ ions imaging in HepG-2 cells and detection in daily life (Test Strip and lake water). Moreover, non-covalent interaction (NCI) and quantum theory of atoms in molecules (QTAIM) analysis were used to study the interaction between MB-M and Cu 2+ ions. By examining the electronic characteristics of the complex using natural bond orbital (NBO), electron density difference (EDD), and frontier molecular orbital (FMO) analysis, the sensitivity of MB-M towards Cu 2+ ions were investigated. The results illustrated that the interactions between MB-M and Cu 2+ ions involved chemisorption.

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Phenothiazine appended thiophene derivative: a trilateral approach to copper ion detection in living cells and aqueous samples

Abstract: A novel phenothiazine-thiophene acetonitrile compound was synthesised through a Knoevenagel condensation reaction. The compound demonstrated selectivity towards Cu2+ and proved to have low cytotoxicity.

Cited by 3 publications

References 51 publications

Thiazole-derived pyrazin-2-carbohydrazide chemosensors: Colorimetric & photoluminescent detection of silver ions for theoretical, environmental, and cell imaging

Thiazole-derived pyrazin-2-carbohydrazide chemosensors: Colorimetric & photoluminescent detection of silver ions for theoretical, environmental, and cell imaging

4-Diphenylaminobenzaldehyde-formulated isonicotinohydrazide for the rapid recognition of Cu2+ ions; Application of RGB tool, pharmaceutical samples, and DFT studies

An activatable NIR turn-on fluorescent probe for copper (II) ion and live cell imaging

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