Phenothiazine Derivatives: Mono-oxygenated Compounds

Houston, D. F.; Kester, E. B.; DeEds, Floyd

doi:10.1021/ja01179a067

Cited by 20 publications

(6 citation statements)

References 2 publications

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“…Phenothiazone was obtained from Dr. G. D. Koritz, and was prepared by the oxidation of phenothiazine with FeCl3 (7). Phenothiazine was obtained from Eastman Chemical Company.…”

Section: Model Metabolitesmentioning

confidence: 99%

Model ecosystem evaluation of the environmental impacts of the veterinary drugs phenothiazine, sulfamethazine, clopidol, and diethylstilbestrol.

Coats¹,

Metcalf²,

Lu³

et al. 1976

Environ Health Perspect

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Four veterinary drugs of dissimilar chemical structure were evaluated for environmental stability and penchant for bioaccumulation. The techniques used were I1) a model aquatic ecosystem (3 days) and (2) a model feedlpt ecosystem 133 days I in which the drugs were introduced via the excreta of chicks or mice. The model feedlot ecosystem was supported by metabolism cage studies to determine the'amount and the form of the drug excreted by the chicks or mice. Considerable quantities of all,the drugs were excreted intact or as environmentally short-lived conjugates.Diethylstilbestrol (DES) and Clopidol were the most persistent molecules, but only DES bioaccumulated to any 4ppreciable degree. Phenothiazine was very biodegradable; sulfamethazine was' relatively biodegradable and only accumulated in the organisms to very low levels.Data from the aquatic model ecosystem demonstrated a good correlation between the partitibn coefficients of the drugs and their accumulation in the fish.

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“…Phenothiazone was obtained from Dr. G. D. Koritz, and was prepared by the oxidation of phenothiazine with FeCl3 (7). Phenothiazine was obtained from Eastman Chemical Company.…”

Section: Model Metabolitesmentioning

confidence: 99%

Model ecosystem evaluation of the environmental impacts of the veterinary drugs phenothiazine, sulfamethazine, clopidol, and diethylstilbestrol.

Coats¹,

Metcalf²,

Lu³

et al. 1976

Environ Health Perspect

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“…Given the observation of doping by PTZ˙ + , it suggested a route to use the synthetic versatility of PTZ to form polymeric dopants that are challenging to form using many conventional molecular dopants. 41–43…”

Section: Resultsmentioning

confidence: 99%

Interfacial doping of semiconducting polymers with phenothiazine-based polymeric ionic liquids

Oh,

Nguyen,

Tran

et al. 2023

J. Mater. Chem. C

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“…Moreover, the spectra indicated a similarity in structure between Compound H and 3H-phenothiazine-3-one (IV). Some investigators (25,32,33) discussed a compound, 7-hydroxy-3H-phenothiazine-3-one (VII), with the same spectral properties and melting point. The Rf values of H and VII in several chromatographic systems were identical (Table VII).…”

Section: Resultsmentioning

confidence: 99%

Oxidative Degradation of Pharmaceutically Important Phenothiazines I: Isolation and Identification of Oxidation Products of Promethazine

Underberg

1978

Journal of Pharmaceutical Sciences

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Phenothiazine Derivatives: Mono-oxygenated Compounds

Cited by 20 publications

References 2 publications

Model ecosystem evaluation of the environmental impacts of the veterinary drugs phenothiazine, sulfamethazine, clopidol, and diethylstilbestrol.

Model ecosystem evaluation of the environmental impacts of the veterinary drugs phenothiazine, sulfamethazine, clopidol, and diethylstilbestrol.

Interfacial doping of semiconducting polymers with phenothiazine-based polymeric ionic liquids

Oxidative Degradation of Pharmaceutically Important Phenothiazines I: Isolation and Identification of Oxidation Products of Promethazine

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