Phenothiazine‐Tethered 2‐Aminopyridine‐3‐carbonitrile: Fluorescent Turn‐Off Chemosensor for Fe ³⁺ Ions and Picric Acid

Abstract

A new fluorescent chemosensor, viz. 2‐amino‐4‐(4‐methoxyphenyl)‐6‐(10H‐phenothiazin‐2‐yl)‐pyridine‐3‐carbonitrile has been synthesized through a facile one‐pot, four‐component domino strategy under solvent‐free microwave heating. This phenothiazine tethered 2‐aminopyridine‐3‐carbonitrile hybrid exhibited strong orange fluorescence under UV lamp and was highly selective and sensitive towards Fe3+ ions and picric acid. The probe displayed a lower limit of detection of 4.9 μM and 98 nM for Fe3+ ions and picric acid in DMSO, respectively.

Hydrogen bond directed high-fidelity optical detection of picric acid: A single driver on diverse roads towards the same destiny

“…4) was reported. 69 Compound 17 simultaneously and independently detected PA (LOD = 98 nM) and Fe 3+ ions in DMSO. 17 displayed orange fluorescence due to ICT.…”

Propylimidazole Functionalized Coumarin Derivative as Dual Responsive Fluorescent Chemoprobe for Picric Acid and Fe3+ Recognition: DFT and Natural Spring Water Applications

“…As seen from Fig S5, the uorescence quenching for PA and Fe 3+ was occurred only within just 30 seconds, and at their uorescence intensities were reached to equilibrium at same response time. Thus, a response time was decided on 30 seconds for the following experiments and the chemoprobe IPC depicted an excellent response time towards PA and Fe 3+ respecting the formerly developed a lot of uorogenic dual chemoprobes [10,[19][20][21].…”

“…To keep away from these drawbacks, uorescent sensing systems have been recently developed due to their superior advantages mentioned above [7,[16][17][18]. However, the literatures based upon to fabricate dual responsive uorescent chemoprobes for the recognition of both PA and Fe 3+ with high selectivity and sensitivity, are still rare [10,[19][20][21]. Therefore, the need is great for more uorescent chemoprobes able to detect the PA and Fe 3+ in real-time and reliably.…”

Review: Fluorophores for detecting Nitroaromatic Compounds, Picric Acid

“…It is used in dyes, pharmaceuticals, firework industries, and also as a chemical explosive in mining. In recent past these explosives have been frequently used by terrorist organization 2 . Chemical explosives contain huge amount of energy stored in the chemical bonds.…”