2007
DOI: 10.1016/j.jphotobiol.2006.07.005
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Phenothiazinium derivatives for pathogen inactivation in blood products

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Cited by 122 publications
(75 citation statements)
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“…MB is a phenothiazine compound which intercalates into viral nucleic acid, and subsequent illumination generates singlet oxygen leading to guanosine oxidation and destruction of the viral nucleic acid preventing viral replication [46,47] (fig. 4).…”
Section: Pathogen Reduction Capacitymentioning
confidence: 99%
“…MB is a phenothiazine compound which intercalates into viral nucleic acid, and subsequent illumination generates singlet oxygen leading to guanosine oxidation and destruction of the viral nucleic acid preventing viral replication [46,47] (fig. 4).…”
Section: Pathogen Reduction Capacitymentioning
confidence: 99%
“…This inactivation deficiency, observed in plasma, cannot be attributed to the decrease in light intensity due to absorption or scattering, because the fresh human plasma used is clear and neither absorbs in the 661-nm excitation wavelength region nor scatters the LED light. Singlet oxygen is the dominant active species responsible for the photoinactivation of bacteria (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21), with MB being the primary photosensitizing agent used for the generation of singlet oxygen and the sterilization of plasma (22)(23)(24)(25)(26)(27). To that effect we investigated possible reactions between plasma and MB that may be responsible for decrease in singlet oxygen generation that would explain the low bacteria inactivation rate in plasma.…”
mentioning
confidence: 99%
“…12 A técnica oferece vantagens como um amplo espectro de ação, sendo eficiente inclusive sobre microrganismos resistentes a antibióticos e apresentando menores efeitos colaterais nocivos quando comparada a outros tratamentos. 8,12,13 Além disso, uma vez que a inativação se dá por meio da produção de espécies altamente reativas com ataque a múltiplos alvos celulares, não se considera possível o desenvolvimento de resistência microbiana. Por essas vantagens, a utilização da TFDA tem se mostrado relevante, por exemplo, na esterilização de bolsas de sangue, na periodontia e no tratamento e conservação de alimentos.…”
Section: 4unclassified