Phenotype frequencies of blood group systems and alloantibodies to red blood cells in blood transfusion recipients in Kayseri (Turkey)

Torun, Yasemin Altuner; Kaynar, Leylagül; Karakükçü, Çiğdem; Yay, Mehmet; Ergül, Ayşe Betül; Turanoglu, Cem; Çetın, Mustafa; Eser, Bülent

doi:10.5455/jtomc.2017.07.097

Cited by 2 publications

(2 citation statements)

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“…The anti-Kell antibody is the most found after anti-D among irregular antibodies about 0.1 for Caine (1986) [13], 0.1 to 0.2% for Grant [14] and 0.16 to 0.21 for Queenan and Poleski on series of 18,378 and 43,000 patients [15]. In a Turkey series the first allo anti bodies were anti-E and anti-Kell [16].…”

Section: Discussionmentioning

confidence: 91%

Kell Blood Group Maternal-Fetal Incompatibility in Lubumbashi (D. R. Congo), Case Report

Kalenga¹,

Nyembo²,

Mwange³

et al. 2017

JPP

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Introduction: The anti Kell is a major cause of hemolytic disease of the newborn; the third cause after ABO and Rhesus in frequency; and the second in terms of severity after rhesus type incompatibility. In Africa, 60% of the population is Kell negative. In Congo, Kell blood group determination is not systematically performed and almost non-existent in perinatology. We aimed to report a case of this immunization in routine practice. Method: This study is a clinical report of Kell immunization. Physical examination was performed and blood group determined. Clinical and biological follow up of the case: a review of the literature of Kell immunizations is included. Result: A female newborn on day 4 of life with weight of 3,250 g born at term admitted to Sendwe's Hospital emergency for pallor and respiratory distress. History reveals jaundice at birth. The mother is P1G4A3D0, blood group Orh+. Clinically the child is pale, jaundiced, present tachycardia, hepatomegaly, polypnea Brh+. The diagnostic orientation is a maternal-fetal incompatibility. The realization of blood grouping Kell, Duffy and irregular antibodies research Kell type confirms the diagnosis of Kell hemolytic disease of the newborn. We discharged him after 14 days. Conclusions: The Kell type IFME is a purveyor of grave hemolytic disease of the newborn. His knowledge, prevention and proper care by a multidisciplinary team can prevent dramatic situations.

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Section: Discussionmentioning

confidence: 91%

Kell Blood Group Maternal-Fetal Incompatibility in Lubumbashi (D. R. Congo), Case Report

Kalenga¹,

Nyembo²,

Mwange³

et al. 2017

JPP

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“…The main databases included, JSTOR, Google Scholar, PubMed and Elsevier. RH2 frequency data were obtained for fourteen Middle East and North African countries [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36], Sub-Saharan countries with low HIV prevalence (SSALo) [16,32,37,38], SSA with high HIV prevalence [16,37,[39][40][41][42][43][44][45][46][47][48]. RH2 prevalence data was also obtained for other countries including data from Europe [20,[49][50][51][52][53][54][55][56][57], Asian countries [20,[58][59][60][61][62]…”

Section: Methodsmentioning

confidence: 99%

Lack of RH2 gene expression may have influenced the HIV pandemic in sub-Saharan Africa

Nthobatsang

Ncenga

Mwangi-Woto

et al. 2020

Aids

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Objective: To evaluate the association between the Rhesus system RH2-blood group expression and susceptibility to HIV infection, viral load, CD4 þ cell count and rate of CD4 þ decline. We also aimed to determine if a country's HIV prevalence may be predicted from its RH2 relative frequency.Design: Our previous studies did not find any HIV-infected RH2 homozygotes. Therefore, the current cross-sectional study analysed a larger sample to determine whether HIV-infection also occurs in homozygotes. We also conducted a crosssectional analysis of RH2 expression in an HIV natural history cohort in Botswana. Lastly, we analysed published data from 60 countries around the world to interrogate the link between RH2 frequency and HIV prevalence.Methods: One thousand and six hundred anticoagulated blood samples (800 HIVpositive and 800 HIV-negative) were phenotyped for RH2 using serological methods. The proportion of RH2-positive samples was compared across categories of HIV status and odds ratios calculated. Mean viral load and CD4 þ cell counts from a natural history cohort study were also compared across categories of RH2. Kaplan-Meier plots were generated for 4-year CD4 þ -decline to 350 cells/ml.Results: No RH2 homozygotes were found among HIV-positives. Moreover, RH2negatives were 1.37 times more likely to be HIV-positive than heterozygotes (P ¼ 0.02) and 33 times more likely than RH2 homozygotes (P ¼ 0.01). RH2-positive patients showed significantly higher mean CD4 þ cell counts (P < 0.0001), lower viral load (P ¼ 0.024) and slower CD4 þ decline (P ¼ 0.038). Conclusion:RH2 is potentially a critical host genetic factor determining susceptibility of any population to HIV infection, and probably transcends most other factors in importance for HIV risk of infection.

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Phenotype frequencies of blood group systems and alloantibodies to red blood cells in blood transfusion recipients in Kayseri (Turkey)

Cited by 2 publications

References 0 publications

Kell Blood Group Maternal-Fetal Incompatibility in Lubumbashi (D. R. Congo), Case Report

Kell Blood Group Maternal-Fetal Incompatibility in Lubumbashi (D. R. Congo), Case Report

Lack of RH2 gene expression may have influenced the HIV pandemic in sub-Saharan Africa

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