2019
DOI: 10.1111/vop.12596
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Phenotype of macular corneal dystrophy in Labrador Retrievers: A multicenter study

Abstract: Objective To describe the phenotype of canine macular corneal dystrophy (MCD) including the clinical presentation, multimodal ocular imaging, histopathology, and ultrastructural analysis in ten Labrador Retrievers. Procedure Multicentered data collection. Results Labrador Retrievers affected by MCD were presented between the age of 4.5 and 6 years of age with a history of cloudy eyes and/or visual impairment. Findings on ophthalmic examination included a diffuse haze of the corneal stroma and multiple, well‐de… Show more

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Cited by 5 publications
(6 citation statements)
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“…1 Macular corneal dystrophy is an inherited progressive disease affecting dogs, especially labrador retrievers, and it is caused by a mutation in the gene CHST6. 15,16 In all these dog breeds, the disease consists of deposition of lipids at various levels of the corneal stroma. In our case, the exact nature of the dystrophy of the ferret has not been investigated, as the crystals detached spontaneously before presentation without a histopathology exam being performed.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…1 Macular corneal dystrophy is an inherited progressive disease affecting dogs, especially labrador retrievers, and it is caused by a mutation in the gene CHST6. 15,16 In all these dog breeds, the disease consists of deposition of lipids at various levels of the corneal stroma. In our case, the exact nature of the dystrophy of the ferret has not been investigated, as the crystals detached spontaneously before presentation without a histopathology exam being performed.…”
Section: Discussionmentioning
confidence: 99%
“…Airedale terriers can also be affected by a form of lipid corneal dystrophy 1 . Macular corneal dystrophy is an inherited progressive disease affecting dogs, especially labrador retrievers, and it is caused by a mutation in the gene CHST6 15,16 . In all these dog breeds, the disease consists of deposition of lipids at various levels of the corneal stroma.…”
Section: Discussionmentioning
confidence: 99%
“…53 Epithelial-stromal corneal dystrophy occurs in an induced mutation in a mouse 43 and probably DB rabbits. 44 Stromal dystrophies were found in an induced mutation in a mouse 32 and spontaneously in several breeds of dogs, [45][46][47][48]50 including a genotypically verified missense mutation that results in macular corneal dystrophy in Labrador retrievers. 51 Numerous induced mutations in mice have been created as models of corneal endothelial dystrophies, 33,35,[37][38][39]42,62,63 and spontaneous endothelium dystrophies have occurred in dogs.…”
Section: Discussionmentioning
confidence: 99%
“…In Labrador Retrievers, a genotypically confirmed carbohydrate sulfotransferase 6 gene mutation results in loss of keratocytes and stromal deposition of PAS and iron positive glycosaminoglycans (GAGs) consistent with macular corneal dystrophy in humans. 45,51 In humans, Schnyder corneal dystrophy (SCD) is a mutation in UbiA prenyltransferase domain containing 1 (UBIAD1) that may result in hyperlipidemia, crystals in the cornea that stain for intracellular and extracellular phospholipids and cholesterol in epithelial cells, Bowman layer, and stroma. Secondary deposition of amyloid and GAGs may also occur.…”
Section: Comparative Literature Review Of Corneal Dystrophy In Animalmentioning
confidence: 99%
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