Phenotypes and Endotypes of Bronchial Asthma: From Pathogenesis and Clinical Features to Therapy

Курбачева, О М; Pavlova, K S

doi:10.36691/rja596

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…34 Prevention and treatment of allergic diseases and BA depends on the effect on the immunological regulation and the function of the immune system. 35 Clinical interpretation of IgE levels in blood serum.…”

Section: Th1 Th2 and Allergic Diseasesmentioning

confidence: 99%

Infectious and Non-Infectious Sensitisation of Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease

Gb¹,

Vi²,

Vg³

et al. 2016

JLPRR

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Section: Th1 Th2 and Allergic Diseasesmentioning

confidence: 99%

Infectious and Non-Infectious Sensitisation of Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease

Gb¹,

Vi²,

Vg³

et al. 2016

JLPRR

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show abstract

“…Among the known risk factors for the development of asthma in children, such as family history of allergies, manifestations of atopy, eosinophilia, leading to frequent episodes of bronchial obstruction, the role of vitamin D (25 (OH) D) and the significance of its deficiency in the tendency to frequent respiratory diseases are being actively studied today. In recent years, the interest of a number of researchers has increased in the possible role of vitamin D and disorders of its metabolism in the pathogenesis of pulmonary diseases [1][2][3][4][5][6][7]. The conducted studies made it possible to identify a statistically significant correlation between vitamin D deficiency and the prevalence of a number of chronic diseases, including pathology of the pulmonary sphere.…”

Section: Introductionmentioning

confidence: 99%

The use of cholecalciferol in the treatment of bronchial asthma in children

Turaeva,

Mukhammadieva,

Mamatkulova

et al. 2023

E3S Web of Conf.

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The results of evaluation of the clinical efficacy of cholecalciferol in the complex treatment of bronchial asthma in children are presented. 60 children with bronchial asthma were examined. All patients were prescribed cholecal ciferol in addition to basic therapy. In all children, the level of the 25(OH)D metabolite was determined in the blood serum. The study of clinical efficacy after treatment showed an increase in the content of vitamin D, in children there was an improvement in the course of the disease: the number of exacerbations per year, the number of night attacks decreased, the length of stay in the hospital was reduced, attacks stopped in a shorter time, the duration of dry and wet cough significantly decreased, it was noted reduction in the duration of shortness of breath, cyanosis of the nasolabial triangle, oral wheezing.

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Immune Mechanisms for Development of Controlled and Partially Controlled Asthma

et al. 2019

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Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied. The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in controlled and partly controlled asthma.We examined eighty-four BA patients that were divided into 2 groups, depending on the control of symptoms and the clinical course of BA. Group I included 45 patients with controlled BA, whereas group II included 39 patients with partially controlled asthma. The subsets of Th1, Th2, and Th17 lymphocytes were assessed by serum cytokine levels (TNFα, IFNγ, IL-2, IL-4, IL-6, IL-10, IL-17A) using flow cytometry technique.The results of this study were as follows: we have shown a combined T-helper (Th) immune response in asthma patients, with its origin depending on the degree of the disease control. Th2 (62%), Th1/Th2 (20%) and Th1 (18%) types of immune response have been detected in the patients with controlled BA. Th2/Th17 (49%), Th1/Th17 (13%) and Th17 (37%) types of immune response have been identified in the patients with partially controlled BA. It has been shown, that Th1 immune response in patients with controlled asthma is induced by intracellular infection. The formation of the Th1/Th2 phenotype is associated with a site of chronic bacterial infection revealed, and with persistence of viral infection in the body. This phenotype can be used as an indicator of asthma worsening. Further studies in the role of prevalent immune response type in the development of partially controlled BA have shown that activation of Th17 lymphocytes is associated with prolonged course of the disease. Irrespectively of initial phenotype, the development of Th17-dependent immune response seems to result from a durable systemic persistent inflammation.The views on the key role of Th1/Th2 balance in the development of asthma are accomplished by evidence of Th17 lymphocyte involvement into the process, and Th1/Th17, Th2/Th17 phenotypes seem to be the polar features of the disease. Estimation of intensity and phenotype of inflammation in BA will permit a more objective evaluation of the therapy applied, and to choose further management strategies.

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Phenotypes and Endotypes of Bronchial Asthma: From Pathogenesis and Clinical Features to Therapy

Cited by 9 publications

References 37 publications

Infectious and Non-Infectious Sensitisation of Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease

Infectious and Non-Infectious Sensitisation of Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease

The use of cholecalciferol in the treatment of bronchial asthma in children

Immune Mechanisms for Development of Controlled and Partially Controlled Asthma

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