2010
DOI: 10.1002/cyto.b.20582
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Phenotypic abnormalities strongly reflect genotype in patients with unexplained cytopenias

Abstract: Conclusions: The high correlation between genotypic and phenotypic abnormalities suggests a possible increased utility of flow cytometry in the diagnosis of patients with unexplained cytopenias and may be useful in future clinical studies and in the classification by the WHO, using the FCSS rather than simple counting of flow cytometric abnormalities.

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Cited by 21 publications
(23 citation statements)
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“…Despite having a significantly higher average Wells FCSS, consistent with what has been previously reported [30], cases with complex cytogenetics (excluding those with a loss of TP53,) did not have a greater frequency of abnormalities in the erythroid lineage. Cases that included a loss of TP53 (8 of 9 of which had a complex karyotype)…”
Section: Correlation Among Cytogenetics Phenotypic Erythroid Abnormasupporting
confidence: 90%
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“…Despite having a significantly higher average Wells FCSS, consistent with what has been previously reported [30], cases with complex cytogenetics (excluding those with a loss of TP53,) did not have a greater frequency of abnormalities in the erythroid lineage. Cases that included a loss of TP53 (8 of 9 of which had a complex karyotype)…”
Section: Correlation Among Cytogenetics Phenotypic Erythroid Abnormasupporting
confidence: 90%
“…The Wells FCSS has been to shown to highly correlate with severity of disease and WHO diagnostic criteria [30]. with the revised Ogata flow score [3] and demonstrated a high level of sensitivity and specificity (with morphology as the standard), two separate processing methods were used, NH 4 Cl lysis for the leukocytes and whole bone marrow for the erythrocytes [21].…”
Section: Discussionmentioning
confidence: 99%
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“…13 The iFS was established as described previously. 25 The diagnostic score, the iFS, and the erythroid score are described in Table 2A.…”
Section: Mds-fc Scoresmentioning
confidence: 99%
“…Moreover, the presence of aberrant Table 1 Example of a MDS-FCM scoring system, applying most of the recommended markers. Adapted from Wells et al [12] scores adjusted as by Cutler et al [37].…”
Section: Prognostic Value Of Flow Cytometrymentioning
confidence: 99%