2006
DOI: 10.1111/j.1365-3083.2006.01849.x
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Phenotypic Analysis of IL‐10‐treated, Monocyte‐derived Dendritic Cells in Patients with Systemic Lupus Erythematosus

Abstract: Dendritic cells (DC) play a dual role in the immune response, participating in its induction, and the maintenance of immune tolerance. The aim of this work was to perform a quantitative and phenotypic analysis of DC generated in vitro in the presence of IL‐10 in patients with systemic lupus erythematosus (SLE). Blood samples were obtained from 10 active and untreated patients with SLE and six controls. Monocyte‐derived DC were generated in vitro in the presence or absence of IL‐10, and a quantitative and pheno… Show more

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Cited by 28 publications
(15 citation statements)
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“…More subtle differences, however, may point to mechanistic diversity. For instance, BiP caused a marked decrease in CD86 expression while minimally affecting HLA‐DR and CD80 positivity, while addition of recombinant IL‐10 alone affects both HLA‐DR and CD86 expression 29 . VIP also induces high concentrations of IL‐10 during DC maturation with LPS, but causes only a slight loss of CD86 and CD80 expression and does not affect HLA‐DR expression 30 .…”
Section: Discussionmentioning
confidence: 99%
“…More subtle differences, however, may point to mechanistic diversity. For instance, BiP caused a marked decrease in CD86 expression while minimally affecting HLA‐DR and CD80 positivity, while addition of recombinant IL‐10 alone affects both HLA‐DR and CD86 expression 29 . VIP also induces high concentrations of IL‐10 during DC maturation with LPS, but causes only a slight loss of CD86 and CD80 expression and does not affect HLA‐DR expression 30 .…”
Section: Discussionmentioning
confidence: 99%
“…Whether IL-10 in the serum of SLE patients plays a similar role in the pathogenesis of SLE remains unknown. It was found that DCs from SLE patients expressed lower levels of HLA-DR, CD86 and CD9 than those from the normal controls[32]. In addition, there is a different response to IL-10 treatment between DCs derived from the monocytes isolated from SLE patients and those from normal controls.…”
Section: Discussionmentioning
confidence: 97%
“…They mediate immune tolerance through the induction of T cell apoptosis, incompetence and regulatory T cells in a variety of mechanisms [20,26]. Tolerogenic DCs can be obtained in vitro by several means and have been widely applied in the solid organ transplantation [8,23,30] and the prevention and treatment of autoimmune diseases [36].…”
Section: Introductionmentioning
confidence: 99%