Phenotypic and allelic profile of ABO and Rhésus D blood group system among blood donor in Antananarivo

Geographical distribution of ABO and RHD antigens is important for blood transfusion services and population genetics studies. There are few data on this topic in Burkina Faso, a multi‐ethnic country. Our study aims at reporting phenotypic and allelic frequencies of ABO and RHD blood groups among voluntary blood donors from various ethnical regions of Burkina Faso. We conducted a cross‐sectional study including 81,486 blood donors. ABO allelic frequencies were determined using the Bernstein method. Differences in phenotypic distribution of blood groups were assessed using the chi‐square test; a p value <0.05 being considered as statistically significant. We noticed that O+>B+>A+>AB+>O‐>B‐>A‐>AB‐ in our population. Phenotypic frequencies of blood groups A, B, O and AB were respectively 22.54%, 28.56%, 43.30% and 5.60%. RHD+was 92.24%. The allelic frequencies of A, B, O and D were respectively 0.1524; 0.1887; 0.6590 and 0.7214. We noticed statistical differences (p < 0.05) between these administrative regions which corresponded roughly to some natural ethnic areas. Indeed, the phenotype O was more frequent in the Central‐west, Central and East regions corresponding to “Mossi,” “Gourounsi,” “Gourmantché” areas while the phenotype A and AB were more reported in “Boucle du mouhoun” and “Hauts‐Bassins” regions where we have “Bwaba” and “Bobo.” The phenotype O negative was less frequent in “Bwaba.” Our study provides interesting information to blood services that will allow them to better refine their donor recruitment strategies.

Section: Discussionsupporting

confidence: 92%

Distribution of ABO and RHD blood group antigens in blood donors in Burkina Faso

Sawadogo

Nébié

Millogo³

et al. 2018

“…These findings are consistent with the trend reported in a study carried out in the Eastern region of Ghana (Kretchy et al, ). Similar studies by Loua, Lamah, Haba, and Camara (), Alimba, Adekoya, and Oboh () and Randriamanantany et al () also reported a similar trend of O > B>A > AB in a Guinean, Nigerian and Madagascan populations, respectively. The predominance of the O phenotype observed in this study is common in other African populations, but there are some slight differences in the distribution of A and B phenotypes.…”

Section: Discussionsupporting

confidence: 80%

Frequency of ABO/Rhesus (D) blood groupings and ethnic distribution in the Greater‐Accra region of Ghana, towards effective blood bank inventory

Doku

Agbozo

Annor

et al. 2019

Knowledge on blood group phenotypes is of key importance in clinical practice. It used in blood transfusion practice to determine the direction of recruitment of voluntary donors as required for each population within a country, and for disease association and population genetics studies. This study aimed at reporting the frequency of ABO and Rhesus (Rh) groups in the population of the Greater‐Accra region of Ghana and amongst their various ethnic groups. A retrospective study in 11 main hospitals within the region was done. Data collected provided information on the blood group status of persons (both blood donors and recipients) who visited the selected hospitals. Medical records used were within the years 2012–2017. A total of 42,317 (26,802 males and 15,515 females) data were retrieved and analysed. The frequencies of the blood groups O, A, B and AB were 50.0%, 24.3%, 20.7% and 5.0%, respectively. Rhesus‐positive to negative ratio was 93.2%/6.2%. Frequencies of blood group O was highest (49.1%–53.6%) in all ethnic groups. The second most dominant blood group was B (24.2%–25.4%) in the Ga‐Adamgbe, Akan and Ewe ethnic groups, whilst blood group A (25.0%–26.9%) was the second most dominant in the Northerners and non‐Ghanaians. Blood group distribution amongst gender and different age groups showed no significant differences but followed the same pattern for the general population. The study provides data on the ethnic distribution and frequency of ABO and Rhesus blood groupings in the Greater‐Accra region of Ghana. It also informs the need for blood banks in the region to increase the proportion of stockpiled Rhesus‐positive blood groups especially for O, B and A that may be high in demand.

“…The distribution of the blood groups A, B, O and AB varies across the world according to the population. The predominance of the O phenotype is common in the majority of sub‐Saharan African populations (Table ), but there are some slight differences in the distribution of phenotypes A and B (Tagny et al ., ,b; Kulkarni et al ., ; Loua et al ., ; Randriamanantany et al ., ; Hamed et al ., ). On the contrary, A and B phenotypes are predominant in some populations in the world: for instance, B phenotype has its highest frequency in Northern India and neighbouring Central Asia, and its incidence diminishes both toward the west and the east, falling to single digit percentages in Spain (Blood Transfusion Division, United States Army Medical Research Laboratory, ; Das et al ., ; Hammed et al ., ).…”

Section: Discussionmentioning

confidence: 99%

“…Blood group A is associated with high frequencies in Europe, especially in Scandinavia and Central Europe, although its highest frequencies occur in some Australian Aboriginal populations and the Blackfoot Indians of Montana [27–29]. As described by the present study, in most of sub‐Saharan African populations, up to 90–95% of people have the phenotype Rhesus‐positive (Tagny et al ., ,b; Kulkarni et al ., ; Loua et al ., ; Randriamanantany et al ., ; Hamed et al ., ). This frequency declines toward North Africa and are considerably lower in Caucasians (Tagny et al ., ,b; Lefrère & Rouger, ; Wagner et al ., ; Garratty et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and allelic distribution of the ABO and Rhesus (D) blood groups in the Cameroonian population

Ndoula

Noubiap

Nansseu

et al. 2014

Data on blood group phenotypes are important for blood transfusion programs, for disease association and population genetics studies. This study aimed at reporting the phenotypic and allelic distribution of ABO and Rhesus (Rh) groups in various ethnolinguistic groups in the Cameroonians. We obtained ABO and Rhesus blood groups and self-identified ethnicity from 14,546 Cameroonian students. Ethnicity was classified in seven major ethnolinguistic groups: Afro-Asiatic, Nilo-Saharan, Niger-Kordofanian/West Atlantic, Niger-Kordofanian/Adamawa-Ubangui, Niger-Kordofanian/Benue-Congo/Bantu/Grassfield, Niger-Kordofanian/Benue-Congo/Bantu/Mbam and Niger-Kordofanian/Benue-Congo/Bantu/Equatorial. ABO allelic frequencies were determined using the Bernstein method. Differences in phenotypic distribution of blood groups were assessed using the chi-square test; a P value <0.05 being considered as statistically significant. The frequencies of the antigens of blood groups O, A, B and AB were 48.62%, 25.07%, 21.86% and 4.45%, respectively. Rhesus-positive was 96.32%. The allelic frequencies of O, A and B genes were 0.6978, 0.1605 and 0.1416, respectively. Phenotypic frequencies of the blood groups in the general study population and in the different ethnolinguistic groups were in agreement with Hardy-Weinberg equilibrium expectations (P > 0.05). The frequencies of O, A, and B blood phenotypes were significantly lower, respectively, in the Nilo-Saharan group (P = 0.009), the Niger-Kordofanian/Benue-Congo/Bantu groups (P = 0.021) and the Niger-Kordofanian/West-Atlantic group. AB blood group was most frequent in the Niger-Kordofanian/Adamawa-Ubangui group (P = 0.024). Our study provides the first data on ethnic distribution of ABO and Rhesus blood groups in the Cameroonian population and suggests that its general profile is similar to those of several sub-Saharan African populations. We found some significant differences in phenotypic distribution amongst major ethnolinguistic groups. These data may be important for blood donor recruitment policy and blood transfusion service in Cameroon.