Phenotypic and genotypic characterization of antibiotic resistance in military hospital-associated bacteria from war injuries in the Eastern Ukraine conflict between 2014 and 2020

Kondratiuk, Viacheslav; Jones, Brendan; Kovalchuk, Valentine; Коваленко, І. М.; Ganiuk, V.; Kondratiuk, Olena; Frantsishko, Alla

doi:10.1016/j.jhin.2021.03.020

Cited by 31 publications

(16 citation statements)

References 10 publications

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“…Some other organisms such as Acinetobacter sp. had been previously associated with wars [16][17][18][19][20]. Recent data suggest that such organisms might be associated with heavy metals contamination [21].…”

Section: Discussionmentioning

confidence: 99%

Burkholderia cepacia Infections at Sites Other than the Respiratory Tract: A Large Case Series from a Tertiary Referral Hospital in Lebanon

Kwayess

Hariri

Hindy

et al. 2022

J Epidemiol Glob Health

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Objectives The Burkholderia cepacia complex (Bcc), which was originally thought to be a single species, represents a group of 24 distinct species that are often resistant to multiple antibiotics, and usually known to cause life-threatening pulmonary infections in cystic fibrosis patients. Herein we describe a series of non-respiratory Bcc infections, the risk factors and epidemiologic factors, in addition to the clinical course. Patients and methods This is a retrospective chart review of 44 patients with documented B. cepacia infections isolated from sites other than the respiratory tract admitted between June 2005 and February 2020 to the American University of Beirut Medical Center (AUBMC), a tertiary referral hospital for Lebanon and the Middle East region. The epidemiological background of these patients, their underlying risk factors, the used antibiotic regimens, and the sensitivities of the B. cepacia specimens were collected. Results The majority of the Bcc infections (26/44, 59.1%) were hospital-acquired infections. The most common nationality of the patients was Iraqi (18/44, 40.9%), and the most common site of infection was bacteremia (17/44, 38.6%), followed by skin and soft tissues infections (16/44, 36.4%) and vertebral osteomyelitis (8/44, 18.2%). Most of the isolated B. cepacia were susceptible to ceftazidime, carbapenems, followed by TMP-SMX. Patients responded well to therapy with good overall outcome. Conclusions Bcc can cause infections outside the respiratory tract, mostly as hospital-acquired infections and in immunocompromised patients. Most patients were referred from countries inflicted by wars raising the possibility of a potential role of conflicts which need to be investigated in future studies. Directed therapy according to susceptibility results proved effective in most patients.

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Section: Discussionmentioning

confidence: 99%

Burkholderia cepacia Infections at Sites Other than the Respiratory Tract: A Large Case Series from a Tertiary Referral Hospital in Lebanon

Kwayess

Hariri

Hindy

et al. 2022

J Epidemiol Glob Health

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“…European surveillance data for Ukraine indicated 18% of S. aureus to be meticillinresistant, while 41% meticillin-resistance was reported in healthcare-associated S. aureus infections [3,8]. However, these percentages are based on isolates from hospitalised patients and may therefore not be representative for MDRO carriage in the community [3,7]. Adding the two extra patients without submitted isolate, the total number of patients was 58.…”

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

“…The European Centre for Disease Prevention and Control (ECDC) advised to pre-emptively isolate patients transferred from hospitals in Ukraine or with a history of hospital admission in Ukraine in the last 12 months and to screen for carriage of MDRO [ 6 ]. Available information from Ukrainian military and general hospitals indicates high prevalence of MDRO in Ukraine between 2014 and 2021 [ 3 , 7 , 8 ]. Percentages of resistance of 17–84% against third-generation cephalosporins and carbapenems among Enterobacterales and P. aeruginosa , and > 50% resistance to carbapenems, fluoroquinolones and aminoglycosides among Acinetobacter species have been reported [ 3 , 7 , 8 ].…”

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

“…Available information from Ukrainian military and general hospitals indicates high prevalence of MDRO in Ukraine between 2014 and 2021 [ 3 , 7 , 8 ]. Percentages of resistance of 17–84% against third-generation cephalosporins and carbapenems among Enterobacterales and P. aeruginosa , and > 50% resistance to carbapenems, fluoroquinolones and aminoglycosides among Acinetobacter species have been reported [ 3 , 7 , 8 ]. European surveillance data for Ukraine indicated 18% of S. aureus to be meticillin-resistant, while 41% meticillin-resistance was reported in healthcare-associated S. aureus infections [ 3 , 8 ].…”

Section: Multidrug-resistant Organisms In the Netherlands And Ukrainementioning

confidence: 99%

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Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022

et al. 2022

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Since March 2022, there has been an emergence of multidrug-resistant organisms (MDRO) in the Netherlands in patients originating from Ukraine (58 patients, 75 isolates). For about half of these patients, recent hospitalisation in Ukraine was reported. Genomic surveillance revealed that the majority of the MDRO represent globally spread epidemic lineages and that 60% contain New Delhi metallo-β-lactamase (NDM) genes. Professionals should be aware of an increase in such MDRO associated with migration and medical evacuation of people from Ukraine.

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“…Being one of the main reasons for the hospitalization of adult Ukrainians, injuries and wounds could also be related to the presence of infections. It may be difficult to successfully provide medical help to Ukrainian patients with war injuries due to possible antibiotic resistance, and changes in the epidemiology of wound infection that occur over time [ 23 , 24 , 25 , 26 ]. Thus, some patients could be referred to other countries, including Poland, in order to obtain extended treatment options, not available in Ukraine.…”

Section: Discussionmentioning

confidence: 99%

Hospitalizations of Ukrainian Migrants and Refugees in Poland in the Time of the Russia-Ukraine Conflict

Lewtak

Kanecki

Tyszko

et al. 2022

IJERPH

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Background: In the face of a sudden influx of several million migrants and war refugees from Ukraine to other European countries, knowledge about the health of Ukrainian citizens becomes increasingly important. The aim of the study is to identify the main health problems of hospitalized Ukrainian citizens residing in Poland in the period from 2014 to June 2022. Methods: This study is based on hospitalization data of Ukrainian patients in Poland taken from the Nationwide General Hospital Morbidity Study. Results: The study group covered 8591 hospitalization records. We observed two hospitalization peaks, one in patients aged 0–5 and the other one in those aged 20–35. After the official outbreak of the war, 2231 Ukrainian citizens were hospitalized in Poland. At this time, the most often reported principal reasons for the hospitalizations of adult women were diseases related to pregnancy, childbirth and the puerperium, whereas in groups of adult men diseases were related to injury, poisoning and certain other consequences of external causes, and in children and adolescents diseases were infectious and parasitic diseases. Conclusions: Our findings may have implications for healthcare policies and service provision to newly arrived migrants and war refugees in target European countries.

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Phenotypic and genotypic characterization of antibiotic resistance in military hospital-associated bacteria from war injuries in the Eastern Ukraine conflict between 2014 and 2020

Cited by 31 publications

References 10 publications

Burkholderia cepacia Infections at Sites Other than the Respiratory Tract: A Large Case Series from a Tertiary Referral Hospital in Lebanon

Burkholderia cepacia Infections at Sites Other than the Respiratory Tract: A Large Case Series from a Tertiary Referral Hospital in Lebanon

Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022

Hospitalizations of Ukrainian Migrants and Refugees in Poland in the Time of the Russia-Ukraine Conflict

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