Phenotypic changes of AADC-only immunopositive premammillary neurons in the brain of laboratory shrew Suncus murinus by systemic administration of monoamine precursors

Spinal Cord Injury Enables Aromatic l-Amino Acid Decarboxylase Cells to Synthesize Monoamines

“…However, balancing this downside, it is well documented that at the lumbar level, the presence of 5-HT (or activation of certain types of 5-HT receptors) is of fundamental importance for the recovery of physiological functions, e.g., locomotion, after SCI (Orsal et al, 2002;Schmidt and Jordan, 2000;Antri et al, 2005). It should be emphasized that the results emerging from the present model system may have substantial relevance for the L-dopa-induced dyskinesia observed in advanced cases of Parkinson's disease (Cenci, 2007;Nahimi et al, 2012) because AADC-only cells in the brain could use L-dopa to produce dopamine (Karasawa et al, 1994;Ugrumov, 2009). …”

“…Because the rat has only three to nine intraspinal 5-HT neurons, their contribution to this residual 5-HT pool must be insignificant (Newton et al, 1986;Newton and Hamill, 1988). However, cells containing aromatic L-amino acid decarboxylase (AADC), the enzyme that catalyzes the conversion of 5-hydroxytryptophan (5-HTP) to 5-HT and of L-dopa to dopamine (Lovenberg et al, 1962;Christenson et al, 1972), occur in many CNS regions (Hökfelt et al, 1973;Jaeger et al, 1984;Eaton et al, 1993;Kitahama et al, 2009). In the spinal cord, AADC cells have been described mainly around the central canal and normally do not contain monoamines (catecholamine or 5-HT;Jaeger et al, 1983;Nagatsu et al, 1988).…”

Phenotypic changes of AADC-only-immunoreactive cells in the alimentary canal of the laboratory shrew, <i>Suncus murinus</i>, induced by systemic administration of monoamine precursors

“…Pearse 4) reported the existence of the APUD group of cells, which take up and decarboxylate amine precursors for the synthesis of amines, and many findings have since been reported on this group of cells 2) . The existence of APUD cells in the brain of vertebrates of lower orders, mainly in circumventricular organs, has also been reported 5) .…”

Immunohistochemical Analysis of Monoaminergic Neurons in the Brain of the Common Marmoset, Callithrix jacchus

“…In the brain of the marmoset, AADC-only-Ir neurons are widely distributed in areas other than the substantia nigra [19]. We have reported that AADC-only-Ir neurons belonging to the amine precursor uptake and decarboxylation (APUD) neuronal group, which have the ability to synthesize amines, are found in the laboratory shrew [13][14][15]. AADC-only-Ir neurons found in the marmoset brain also likely belong to the APUD neuronal group.…”