Phenotypic Characteristics of &amp;lt;i&amp;gt;Klebsiella pneumoniae&amp;lt;/i&amp;gt; Extended Spectrum β-Lactamases Producers Isolated in Hospitals in the Littoral Region, Cameroon

Teghonong, Jean; Ebongue, Cécile Okalla; Yadufashije, Callixte; Kojom, Loick Pradel; Adiogo, Dieudonné

doi:10.11648/j.ejcbs.20200601.13

Cited by 3 publications

(7 citation statements)

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“…A similar pooled prevalence of neonatal sepsis in East Africa was documented by Abate et al (2020) [35] while Belachew and Tewabe (2020) recorded a pooled prevalence of neonatal sepsis in Ethiopia of 49.98% [36]. The observed difference and the high prevalence either in children and all age groups in this review may be due to the small sample size of many included studies [20, 22, 27, 28], the study design as well as the study periods. The study revealed that Enterobacterales including Klebsiella spp.…”

Section: Discussionsupporting

confidence: 81%

“…This prevalence is higher than those reported in Africa [32][33][34]. The observed difference in this review may be due to the small sample size of many included studies [20,22,26,27] and their study design. The study revealed that Enterobacterales, including Escherichia coli (23.09%) and Klebsiella spp.…”

Section: Discussioncontrasting

confidence: 62%

“…A total of 4223 blood cultures were obtained from the 10 included studies, 920 (21.79%) of which were performed exclusively in the paediatric population (children under 2 years old). The studies were conducted in two of the 10 regions of Cameroon and included patients from only two cities, Douala (n=2547; 60.31%) [20][21][22] and Yaoundé (n=1676; 39.69%) [23][24][25][26][27][28][29]. Most of the studies were cross-6 sectional (n=08) [20,[22][23][24][25][27][28][29], one was longitudinal [26] and one was retrospective [21], but all were of low risk.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The studies were conducted in two of the 10 regions of Cameroon and included patients from only two cities, Douala (n=2547; 60.31%) [20][21][22] and Yaoundé (n=1676; 39.69%) [23][24][25][26][27][28][29]. Most of the studies were cross-6 sectional (n=08) [20,[22][23][24][25][27][28][29], one was longitudinal [26] and one was retrospective [21], but all were of low risk. Only cross-sectional studies reported the age of the patients, which ranged from 0 to 92 years (Table S1).…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…22.95%; 95% CI= 13.09%-37.07%), Enterobacter spp. (7.66%; 95% CI= 4.46%-12.83%) and Salmonella enterica (7.15%; 95% CI= 3.68%-13.43%).…”

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confidence: 99%

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Bacterial Bloodstream Infections in Cameroon: A Systematic Review and Meta-Analysis of Prevalence and Antibiotic Resistance

Matakone,

Koudoum,

Zemtsa

et al. 2024

Preprint

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Background:The paucity of data on the epidemiology of bloodstream infection (BSI) in developing countries hampers its effective prevention and management. This review sought to provide the current prevalence, bacteriological and antimicrobial resistance profiles of bacteria implicated in BSI in Cameroon.Methods:PubMed and Google Scholar databases were searched to identify relevant articles. Data was analysed using comprehensive meta-analysis software. The I2was used to evaluate heterogeneity between studies, funnel plot and Egger's test to evaluate publication bias and random-effects analysis models to calculate pooled prevalence.Results:The 10 eligible studies were carried out in only two of the 10 regions of Cameroon and investigated 4,223 participants, of whom 920 were children under two years old. The overall pooled prevalence of bacterial BSI was 26.36% (95% CI= 17.51%-37.64%).Klebsiellaspp. (28.20%; 95%CI= 2.80%-63.60%),Escherichia coli(18.94%; 95%CI= 13.02%-26.72%) andStaphylococcus aureus(14.40%; 95%CI= 8.31%-23.81%) were the most incriminated bacteria species.E. coliandKlebsiellaspp. displayed the highest resistance to amoxicillin (82.6%; 95%CI= 63.3%-92.9 vs 86.4%; 95%CI= 55.9%-97.0%), amoxicillin + clavulanic acid (71.7%; 95%CI= 0.44%-89.2% vs 73.1%; 95%CI= 38.7%-92.1%) and trimethoprim/sulfamethoxazole (76.2%; 95%CI= 51.3%-90.7% vs 69.5%; 95%CI= 52.3-82.6%) respectively. However, meropenem (26.7%; 95%CI= 20.8%-33.7%) and fosfomycin (14.9%; 95%CI= 9.1%-23.4%) were the least resistant inE. coliandKlebsiellaspp. respectively.Staphylococcus aureusshowed high resistance to penicillin (84.4%; 95%CI= 68.1%-93.2%), erythromycin (41.5%; 95%CI= 28.0%-56.5%) and oxacillin (37.4%; 95%CI= 8.8%-78.7%) and low resistance to rifampicin (2.9%; 95%CI= 0.6%-13.4%), fusidic acid (8.1%; 95%CI= 3.4%-18.0%) and vancomycin (13.6%; 95%CI= 2.2%-52.9%).Conclusion:This study reports a high prevalence of bacterial BSIs in Cameroon and the high resistance of these bacteria to common antibiotics. There is a pressing need to conduct BSI surveillance studies in all regions of Cameroon to generate data for evidence-based measures regarding BSI prevention and management.Keywords:Bloodstream infection, epidemiology,Enterobacterales, antibiotic resistance, Cameroon.

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 62%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…22.95%; 95% CI= 13.09%-37.07%), Enterobacter spp. (7.66%; 95% CI= 4.46%-12.83%) and Salmonella enterica (7.15%; 95% CI= 3.68%-13.43%).…”

mentioning

confidence: 99%

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Bacterial Bloodstream Infections in Cameroon: A Systematic Review and Meta-Analysis of Prevalence and Antibiotic Resistance

Matakone,

Koudoum,

Zemtsa

et al. 2024

Preprint

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Prevalence, antimicrobial resistance patterns and ESBL resistance genotypes of Klebsiella pneumoniae Isolated from patients presenting with urinary tract infections at Mama Lucy Hospital, Kenya

Muhimpundu,

Mabeya,

Mwaniki

et al. 2024

IJMMTD

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: Multidrug -resistance in has increased rapidly and present a global public health challenge. This challenge has resulted from the Extended Spectrum Beta-Lactamase (ESBL) producers rendering most of beta-lactam antibiotics ineffective posing a therapeutic threat. This study was carried out to determine the prevalence, antimicrobial susceptibility profiles, and ESBL specific resistant genes in isolated from urinary tract-infected patients at Mama Lucy Hospital. : A cross-sectional study was conducted among consenting 400 suspected urinary tract infected patients visiting Mama Lucy hospital, Kenya. Midstream urine samples were collected, cultured,identified and antimicrobial susceptibility patterns determined using the disc diffusion method and ESBL production detected using double disc synergy test. The ESBL positive phenotypes were then confirmed by PCR targeting four beta-lactamase SHV, TEM, CTX-M and OXA genes. : A total of 400 participants were found to have UTIs. The females’ participants were 77.25% while males were 22.75%. The majority participants were between 30-35 years of age (33.5%). Out of the total 400 participants, accounted for 40 (19.41%) out of which 30 (75%) were confirmed ESBL positive. High resistance was observed against Ampicillin (84.37%), while 40.62% showed an equal resistance to Ceftriaxone, and Cefotaxime and Sulfamethoxazole-trimethoprim with 37.50%. Chloramphenicol 96.87%, and Nitrofurantoin 90.62% were effective to isolates. None of the isolates showed resistance to Imipenem. The TEM (66.66%) was the most prevalent ESBL gene detected, SHV at 60%, CTX-M at 40% and the least was OXA at 3.33%. : The high prevalence of , and high trends of ESBL resistance genes were observed. The routine laboratory testing for ESBL phenotypic and molecular methods is recommeded to optimize antibiotic management and reduce the risk of spread of infections caused by ESBL producers.

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Pattern of antibiotics resistance and phenotypic characterization of Multidrug resistant bacteria isolates in four hospitals of Littoral region, Cameroon

Takemegni

Clement

Ateudjieu

et al. 2021

J. Drug Delivery Ther.

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Objective: To describe the pattern of antibiotics resistance and phenotypic characterization of Multidrug resistant bacteria isolates in four hospitals of Littoral region, Cameroon. Methods: We conducted a descriptive hospital based cross-sectional study from December 2018 to May 2019. A simple random sampling was used to swap 10 selected equipment and 10 materials in the mornings after disinfection but before the start of work in seven units. After inoculation in four agar media consecutively (Eosine Metyleine blue, Cled, Manitol salt agar and blood agar ) and incubated in appropriate conditions, the Kirby-Bauer disk-diffusion method was used for antimicrobial susceptibility test. Results: Among 50.4% (119/236) showed positive bacteria growth, a total of 89 (13 species), predominant bacteria and those more likely to cause nosocomial infections were selected and tested each one to 18 antibiotics. There was high level of resistance to Penicillin (amoxicillin (77.5%) and Oxacillin (76.4%)), followed by 3G Cephalosporine (Ceftazidime (74.2%)) and Monobactam (Aztreonam (70.8%)). Although the least level of resistance was observed in Carbapenem (imipenem (5.6%)). The overall prevalence of MDRB was 62.9% (56/89). MRSA were the mostly detected 57.5 % (30/89), followed by ESBL 10.1% (9/89). Military hospital of Douala and Emergency unit was the MDRBs dominantly contaminated area respectively 39.3% (22/56) and 17.9% (10/56). Conclusion: MDRB occurred to be a current public health problem as well as hospital surfaces are worrying reservoir that can be spread to patient, health professionals and visitors. Keywords: Antibiotic resistance, susceptibility test, multidrug-resistant bacteria, Hospital facilities, Units, Littoral Region-Cameroon

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Phenotypic Characteristics of <i>Klebsiella pneumoniae</i> Extended Spectrum β-Lactamases Producers Isolated in Hospitals in the Littoral Region, Cameroon

Cited by 3 publications

References 0 publications

Bacterial Bloodstream Infections in Cameroon: A Systematic Review and Meta-Analysis of Prevalence and Antibiotic Resistance

Bacterial Bloodstream Infections in Cameroon: A Systematic Review and Meta-Analysis of Prevalence and Antibiotic Resistance

Prevalence, antimicrobial resistance patterns and ESBL resistance genotypes of Klebsiella pneumoniae Isolated from patients presenting with urinary tract infections at Mama Lucy Hospital, Kenya

Pattern of antibiotics resistance and phenotypic characterization of Multidrug resistant bacteria isolates in four hospitals of Littoral region, Cameroon

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