Phenotypic Characterization and Antifungal Susceptibility Pattern to Fluconazole in Candida species Isolated from Vulvovaginal Candidiasis in a Tertiary Care Hospital

Ragunathan, Latha; Poongothai, G.K; Sinazer, Annie Rofeena; Kannaiyan, Kavitha; Gurumurthy, H.; Jaget, Nirmala; Kuthalaramalingam, Sethumadhavan

doi:10.7860/jcdr/2014/7434.4311

Cited by 11 publications

(15 citation statements)

References 20 publications

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“…Vijaya et al 14 reported a prevalence of 17.7% in a study conducted in Karnataka on 300 women which is lower than the present study whereas Oviasogie et al study 15 reported a prevalence of 44.8% in a study done at Nigeria. The prevalence of 22.8% in the present study is comparable to most of other studies [11][12][13] except in the study done by Oviasogie et al in Nigeria 15 where a higher prevalence of 44.8% is seen. The high prevalence might be due to the study group which consisted of only pregnant women.…”

Section: Discussionsupporting

confidence: 88%

“…Thus the prevalence of VVC in the present study was 22.8. Kalaiarasan et al study, 11 Jindal et al study 12 and Raghunathan et al 13 study reported a prevalence of 23.7%, 23% and 22.2% respectively which is comparable to the present study. Vijaya et al 14 reported a prevalence of 17.7% in a study conducted in Karnataka on 300 women which is lower than the present study whereas Oviasogie et al study 15 reported a prevalence of 44.8% in a study done at Nigeria.…”

Section: Discussionsupporting

confidence: 87%

“…Study by Jindal et al 12 in Amritsar on 400 patients, reported that 36.8% of 92 culture positives women used oral contraceptive pills which is higher than that of present study. Whereas study done by Raghunathan et al 13 on 180 women showed positivity of only 7.5% in OCP users which is lower than that of present study. Use of contraceptive pills has been reported to increase the occurrence of vaginal candidial infection.…”

Section: Discussioncontrasting

confidence: 84%

“…Findings similar to the present study was reported in the Kalaiarasan et al study, 11 where PID was associated with 32% of 50 culture positives, whereas infertility and diabetes, each were associated in 2% of culture positive cases. The study conducted by Raghunathan et al 13 in Puducherry reported that 15% of the 40 culture positives were related to diabetes mellitus. The positivity of diabetes as co morbid condition in respect with VVC was seen to be higher in this study as compared to the present study.…”

Section: Discussionmentioning

confidence: 98%

“…In this study maximum cases 48.5% were found in age group of 20-29 years. In a study by Raghunathan et al 13 conducted at Puducherry on 180 patients, 40 (22.2%) were culture confirmed cases. Maximum number of patients 82/180 (45.5%) were seen in age group of 26 to 35 years which was similar to the present study.…”

Section: Discussionmentioning

confidence: 98%

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2019

MIJMIC

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Background: Vulvovaginal candidiasis is a commonly reported gynecological condition. It is a major cause of mental distress and economic costs in women of reproductive age group. Aim: To determine the prevalence of vulvovaginal candidiasis in symptomatic women of reproductive age group. Material and Methods: A total number of 184 women aged 15-45 years, attending obstetrics and gynecology outpatient department were included in the present study. A detailed clinical history was taken from the patients regarding age, use of contraception, associated comorbid conditions. Two high vaginal swabs were collected from posterior vaginal wall with aseptic precautions and sent to Microbiology department for further processing. Results: The prevalence of VVC in the present study was 22.8%. Amongst various age groups, 26-30yr (40%) followed by 31-35yr (22.6%) and 21-25yr (16.7%) showed higher percent of Candida positive cases. PID 12 (28.6%) was most commonly associated followed by cases having previous episode of vaginitis 4 (9.5%).OC Pill 9 (21.4%) was most commonly used contraceptive followed by Condom 8 (19.1%). Conclusion: A prevalence of 22.8% of vaginal candidiasis was found in women of reproductive age group of 15-45 years in the present study. Candida species can cause infection at any point in the reproductive life leading to genital discomfort and is a major reason for frequent hospital visits.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 84%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

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2019

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Emergence of Candida glabrata in vulvovaginal candidiasis should be attributed to selective pressure or virulence ability?

Nakamura-Vasconcelos

Fiorini

Zanni

et al. 2017

Arch Gynecol Obstet

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Identification and pattern of antifungal susceptibility of Candida species isolated from cases of vaginitis in a tertiary care hospital in India

Bashir

Altaf

Khurshid

et al. 2023

IJM

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Background and Objectives: Vulvovaginal candidiasis (VVC) is one of the most frequent reasons for gynecological consul- tations. Candida albicans is responsible in the majority of cases. Lately, VVC caused by non-albicans Candida spp. (NAC), which are resistant to routinely used antifungals, is on the rise. This study was designed to determine the prevalence of Candida in patients suffering from vaginitis and to assess the predisposing factors along with identification of Candida species and evaluation of their susceptibility profile. Materials and Methods: High vaginal swabs were collected from 225 women. Sample processing consisted of Gram stain and culture onto Sabouraud’s dextrose agar and HiChrom Candida Differential agar. Isolates were identified and speciated using VITEK2 Compact System. Susceptibility testing was done using VITEK2 AST-Y S08 cards and disc diffusion. Results: Candida spp. were isolated from 94 (41.8%) of the cases. C. albicans was the predominant species (71.6%) fol- lowed by other NAC spp. (28.4%). Pregnancy and diabetes were the most frequently implicated risk factors (67.1% and 44.4%). High resistance was observed in NAC spp. as opposed to C. albicans to all antifungal agents tested. Conclusion: Empirical therapy with routinely used antifungals can be initiated for C. albicans. In the case of NAC spp., identification should be followed by susceptibility testing.

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Phenotypic Characterization and Antifungal Susceptibility Pattern to Fluconazole in Candida species Isolated from Vulvovaginal Candidiasis in a Tertiary Care Hospital

Cited by 11 publications

References 20 publications

Untitled

Untitled

Emergence of Candida glabrata in vulvovaginal candidiasis should be attributed to selective pressure or virulence ability?

Identification and pattern of antifungal susceptibility of Candida species isolated from cases of vaginitis in a tertiary care hospital in India

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