Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research

Chehade, Mirna; Jones, Stacie M.; Pesek, Robbie D.; Burks, A. Wesley; Vickery, Brian P.; Wood, Robert A.; Leung, Donald Y.M.; Furuta, Glenn T.; Fleischer, David M.; Henning, Alice K.; Dawson, Peter; Lindblad, Robert; Sicherer, Scott H.; Abonia, J. Pablo; Sherrill, Joseph D.; Sampson, Hugh A.; Rothenberg, Marc E.

doi:10.1016/j.jaip.2018.05.038

Cited by 94 publications

(93 citation statements)

References 38 publications

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“…The remaining EGIDs cause abdominal pain, vomiting, and/or diarrhea, with blood in the stool also occurring in some patients with colitis. 6 FPIES, FPIP, and food proteineinduced allergic dysmotility disorders affect children more commonly during infancy. Although FPIES can cause nonspecific GI symptoms (abdominal pain, vomiting, and/or diarrhea) and failure to thrive in the chronic phase, children with acute FPIES can experience shock in the event of reexposure to the culprit food after a period of avoidance.…”

Section: Introductionmentioning

confidence: 99%

Feeding difficulties in children with non–IgE-mediated food allergic gastrointestinal disorders

Chehade

Beauregard

2019

Annals of Allergy, Asthma & Immunology

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NoneIgE-mediated food allergic gastrointestinal (GI) disorders can disrupt a child's feeding skill acquisition, resulting in feeding difficulties. Symptoms related to noneIgE-mediated food allergic GI disorders can affect the relationship children have with food. Overly restricted dietary elimination diets in early childhood can limit exposure and increase feeding difficulties. Feeding difficulties can result in nutritional deficiencies and faltering growth. Therefore, timely recognition and referral for management are of paramount importance. Several management approaches to feeding difficulty exist, dictated by the type of feeding difficulty present. Successful management of a child with feeding difficulty is best achieved using a multidisciplinary approach, with addressing the child's feeding and the caregiver feeding style being equally important.

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Section: Introductionmentioning

confidence: 99%

Feeding difficulties in children with non–IgE-mediated food allergic gastrointestinal disorders

Chehade

Beauregard

2019

Annals of Allergy, Asthma & Immunology

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“…In evaluating 20 to 27 OFCs with reactions for each food and more than 446 accidental reactions, the data support the conclusion that these exposures were not associated with significant increases in sensitization to milk, egg, or peanut. 17 Table I 13,17,18 provides practical lessons from these studies that could be used for educating families about food allergy management.…”

Section: Observational Insights From Cofar Studies Natural History Ofmentioning

confidence: 99%

“…CoFAR also sought to gain insights into EoE by establishing a registry enrolling children and adult subjects with this disease. 18 The registry includes 705 subjects, with age at enrollment ranging from 0.9 to 56.2 years (median, 11.2 years). Failure to thrive was common (21%), and gastrointestinal eosinophilia was noted in about 10% of the cohort.…”

Section: Cofar Eosinophilic Esophagitis Registrymentioning

confidence: 99%

“…Delayed EoE diagnosis is common. 18 A high index of suspicion for EoE should be maintained. Comorbidity in patients with EoE is common.…”

Section: Therapeutic Insights From Cofar Studies Intervention Trialsmentioning

confidence: 99%

“…Comorbidity in patients with EoE is common. 18 The possibility of coincident eosinophilic gastritis and immune and neurodevelopmental disorders is to be considered. study that peanut SLIT safely induced a modest level of desensitization in a majority of subjects compared with placebo.…”

Section: Therapeutic Insights From Cofar Studies Intervention Trialsmentioning

confidence: 99%

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The Consortium for Food Allergy Research (CoFAR): The first generation

Sampson

Berin

Plaut

et al. 2019

Journal of Allergy and Clinical Immunology

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The Consortium for Food Allergy Research (CoFAR) was established by the National Institute of Allergy and Infectious Diseases in 2005 as a collaborative research program bringing together centers focused on the study of food allergy. CoFAR was charged with developing studies to better understand the pathogenesis and natural history of food allergy, as well as potential approaches to the treatment of food allergy. In its first iteration an observational study of infants with milk and egg allergy was established, and studies of oral immunotherapy for egg allergy and sublingual immunotherapy for peanut allergy were initiated, as was a phase 1 study of a recombinant peanut protein vaccine. CoFAR was renewed in 2010 for an additional 5-year period during which the initial observational study was continued, a study of eosinophilic esophagitis was initiated, and new therapeutic trials were established to study epicutaneous immunotherapy for peanut allergy and to compare the safety and efficacy of egg oral immunotherapy to the ingestion of baked egg for the treatment of egg allergy. The results of these efforts will be reviewed in this rostrum, with a brief look to the future of CoFAR. (J Allergy Clin Immunol 2019;143:486-93.)

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