Phenotypic characterization of Hanwoo (native Korean cattle) cloned from somatic cells of a single adult

Yang, Byoung‐Chul; Lee, Seung Hwan; Hwang, Seong Soo; Lee, Hwi Cheul; Im, Gi Sun; Kim, Dong Hoon; Lee, Dong Kyeong; Lee, Kyung Tai; Jeon, Ik Soo; Oh, Sung Jong; Park, Soo Bong

doi:10.5483/bmbrep.2012.45.1.38

Cited by 3 publications

(2 citation statements)

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“…Selective sweep signatures may have contributed to the domestication process (3,4). Despite various Hanwoo (Korean native cattle) mapping and diversity studies (5,6), the identification of mutations affecting some quantitative phenotypes (7,8), and several expression studies (9-11), selective sweep signatures in these animals have not been identified. There have been several attempts to conduct such characterization at the population level of other cattle by detecting selective sweep signatures (1,2).…”

Section: Introductionmentioning

confidence: 99%

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Genetic variants and signatures of selective sweep of Hanwoo population (Korean native cattle)

Lee¹,

Cho²,

Seo³

et al. 2013

BMB Reports

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Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequencedthe genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445 CNVs. The SNPs, INDELs, and CNVs were similarly distributed throughout the genome, and highly variable regions were shown to contain the BoLA family and GPR180, which are related to adaptive immunity. We also identified the domestication footprints of the Hanwoo population by searching for selective sweep signatures, which revealed the RCN2 gene related to BPV resistance. The results of this study may contribute to genetic improvement of the Hanwoo population in Korea. [BMB Reports 2013; 46(7):346-351]

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Section: Introductionmentioning

confidence: 99%

“…Large structural variations can be attributed to inversions and translocations, duplications, and deletions. Although existing at lower rates than SNPs, CNVs and INDELs comprise another important type of genomic variation (11) that can be used to better understand genome features.…”

Section: Introductionmentioning

confidence: 99%

Genetic variants and signatures of selective sweep of Hanwoo population (Korean native cattle)

Lee¹,

Cho²,

Seo³

et al. 2013

BMB Reports

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Stochastic developmental variation, an epigenetic source of phenotypic diversity with far-reaching biological consequences

2015

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This article reviews the production of different phenotypes from the same genotype in the same environment by stochastic cellular events, nonlinear mechanisms during patterning and morphogenesis, and probabilistic self-reinforcing circuitries in the adult life. These aspects of phenotypic variation are summarized under the term 'stochastic developmental variation' (SDV) in the following. In the past, SDV has been viewed primarily as a nuisance, impairing laboratory experiments, pharmaceutical testing, and true-to-type breeding. This article also emphasizes the positive biological effects of SDV and discusses implications for genotype-to-phenotype mapping, biological individuation, ecology, evolution, and applied biology. There is strong evidence from experiments with genetically identical organisms performed in narrowly standardized laboratory set-ups that SDV is a source of phenotypic variation in its own right aside from genetic variation and environmental variation. It is obviously mediated by molecular and higher-order epigenetic mechanisms. Comparison of SDV in animals, plants, fungi, protists, bacteria, archaeans, and viruses suggests that it is a ubiquitous and phylogenetically old phenomenon. In animals, it is usually smallest for morphometric traits and highest for life history traits and behaviour. SDV is thought to contribute to phenotypic diversity in all populations but is particularly relevant for asexually reproducing and genetically impoverished populations, where it generates individuality despite genetic uniformity. In each generation, SDV produces a range of phenotypes around a well-adapted target phenotype, which is interpreted as a bet-hedging strategy to cope with the unpredictability of dynamic environments. At least some manifestations of SDV are heritable, adaptable, selectable, and evolvable, and therefore, SDV may be seen as a hitherto overlooked evolution factor. SDV is also relevant for husbandry, agriculture, and medicine because most pathogens are asexuals that exploit this third source of phenotypic variation to modify infectivity and resistance to antibiotics. Since SDV affects all types of organisms and almost all aspects of life, it urgently requires more intense research and a better integration into biological thinking.

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Disentangling the environmentally induced and stochastic developmental components of phenotypic variation

Vogt

2020

Phenotypic Switching

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Phenotypic characterization of Hanwoo (native Korean cattle) cloned from somatic cells of a single adult

Cited by 3 publications

References 23 publications

Genetic variants and signatures of selective sweep of Hanwoo population (Korean native cattle)

Genetic variants and signatures of selective sweep of Hanwoo population (Korean native cattle)

Stochastic developmental variation, an epigenetic source of phenotypic diversity with far-reaching biological consequences

Disentangling the environmentally induced and stochastic developmental components of phenotypic variation

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