Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Neutrophils in Disease Severity

Wang, X; Villa, C; Dobarganes, Y; Olveira, C; Girón, R; García-Clemente, M; Carro, L Máiz; Sibila, O; Golpe, R; Menéndez, R; Rodríguez-López, J; Prados, C; Martínez-García, Miguel-Ángel; Rodriguez, J. Luis; Rosa, D De La; Duran, X; Garcia-Ojalvo, J; Barreiro, E

doi:10.1183/13993003.congress-2022.2252

Cited by 1 publication

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“…Wang et al, demonstrated that patients with a blood neutrophil count above 4990 cells/µL exhibit more severe disease, worse lung function and nutritional status [109]. Likewise, a profile of airway inflammation, characterised by increased expression of IL-8, IL-1β, neutrophil elastase and matrix metalloproteinases, is associated with poor biophysical properties of sputum (e.g., increased mucus solid content and poor visco-elastic properties), worse lung function and radiological severity in bronchiectasis [110].…”

Section: Inflammatory Endotypesmentioning

confidence: 99%

“…Peripheral blood neutrophils show prolonged survival and delayed apoptosis in bronchiectasis [ 105 ], perpetuating the vicious cycle/vortex model of bronchiectasis pathogenesis, where airway dysfunction, airway inflammation, infection and structural damage are linked [ 106 ]. W ang et al [ 107 ] demonstrated that patients with a blood neutrophil count above 4990 cells·µL −1 exhibit more severe disease, worse lung function and nutritional status. Likewise, a profile of airway inflammation, characterised by increased expression of IL-8, IL-1β, neutrophil elastase and matrix metalloproteinases, is associated with poor biophysical properties of sputum ( e.g.…”

Section: Bronchiectasismentioning

confidence: 99%

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ERS International Congress 2022: highlights from the Airway Diseases Assembly

et al. 2023

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The European Respiratory Society (ERS) celebrated the return of an in-person meeting in Barcelona, Spain, after two years of virtual congresses. The congress programme was replete with symposia, skills workshops and abstract presentations from all 14 assemblies, encompassing over 3000 abstracts presented in the form of thematic poster discussion and oral presentations. In this article, highlights from this year's congress (including that from thematic poster sessions, oral presentations and symposia from keynote speakers), presented by Assembly 5: Airway diseases, Asthma, COPD and Chronic Cough, are reviewed by Early Career Members and experts in the field, with the aim of presenting key recent findings in the field.

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Section: Inflammatory Endotypesmentioning

confidence: 99%