2000
DOI: 10.1242/jeb.203.2.295
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Phenotypic Effects of Leptin in an Ectotherm: A New Tool to Study the Evolution of Life Histories and Endothermy?

Abstract: Leptin is a hormone that regulates energy expenditure and body mass in mammals, and it has attracted considerable attention because of its potential in treating human obesity. Comprehensive data from both pathological and non-pathological systems strongly support a role for leptin in regulating energy metabolism, in thermoregulation and in regulating the onset of puberty. We report here that daily injections of recombinant murine leptin in fence lizards (Sceloporus undulatus) produce phenotypic effects similar… Show more

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Cited by 69 publications
(5 citation statements)
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“…Because female tegus remain with their egg clutches throughout the incubation period (33) and lepidosaurs are the sister taxa to birds and other archosaurs, the results also lend support to the parental care model of endothermy in which enhanced parental metabolic capacity could be selected to facilitate increased nest temperature or enhance nest thermal stability, which are known to speed up or alter the developmental rates of embryos in reptiles (13). The reason male tegus also exhibit these changes in temperature could be common seasonal hormonal (for example, estradiol, leptin, or thyroid hormone) surges with pyrogenic potential (48)(49)(50), that sperm production and gonadal regrowth are energetically expensive (18), that spermatogenesis requires elevated temperatures (37,38), that the rapid rise in testosterone following a period of hibernation, leads to intense androgenic effects (28) such as seasonal changes in secondary sexual morphologies (31), or simply that the genetic processes supporting maternal endothermy are shared in offspring of both sexes and not linked to sex chromosomes (13).…”
Section: Resultssupporting
confidence: 57%
“…Because female tegus remain with their egg clutches throughout the incubation period (33) and lepidosaurs are the sister taxa to birds and other archosaurs, the results also lend support to the parental care model of endothermy in which enhanced parental metabolic capacity could be selected to facilitate increased nest temperature or enhance nest thermal stability, which are known to speed up or alter the developmental rates of embryos in reptiles (13). The reason male tegus also exhibit these changes in temperature could be common seasonal hormonal (for example, estradiol, leptin, or thyroid hormone) surges with pyrogenic potential (48)(49)(50), that sperm production and gonadal regrowth are energetically expensive (18), that spermatogenesis requires elevated temperatures (37,38), that the rapid rise in testosterone following a period of hibernation, leads to intense androgenic effects (28) such as seasonal changes in secondary sexual morphologies (31), or simply that the genetic processes supporting maternal endothermy are shared in offspring of both sexes and not linked to sex chromosomes (13).…”
Section: Resultssupporting
confidence: 57%
“…quiescent period, but that it increases during the previtellogenic period and might be related to vitellogenin synthesis [29]. However, no leptin was found in the liver of the lizard S. undulatus [25], though in this species higher leptin titres were observed in a reproductive population [39]. Therefore, our data indicate a probable neuroendocrine role of leptin also in these oviparous lizards, which have a seasonal reproductive cycle.…”
Section: Discussionmentioning
confidence: 63%
“…Daily injections of recombinant murine leptin in fence lizards, S. undulates, produced phenotypic effects similar to those observed when leptin injections are given to mice [25]. A direct and in vitro action of human leptin on FSH and LH release has been reported in rainbow trout at different stages of its sexual cycle [37].…”
Section: Discussionmentioning
confidence: 71%
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