Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor ‘knockout’ mice

Tomiyama, Katsunori; McNamara, Fergal N; Clifford, J.; Kinsella, Anthony; Drago, John; Tighe, Orna; Croke, David T.; Koshikawa, Noriaki; Waddington, John L.

doi:10.1016/s0028-3908(02)00023-0

Cited by 30 publications

(34 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and analysed using repeated-measures analysis of variance (ANOVA) after square-root transformation in the absence of appropriate non-parametric techniques; univariate comparisons were made where overall effects on ANOVA were significant, using Student's t-test or Mann-Whitney U-test after Kruskal-Wallis analysis as appropriate Ross et al, 2000;Tomiyama et al, 2001Tomiyama et al, , 2002Tomiyama et al, , 2004Makihara et al, 2004;Nally et al, 2003Nally et al, , 2004O'Sullivan et al, 2004O'Sullivan et al, , 2005. Fienberg et al, 1998;Nally et al, 2003Nally et al, , 2004.…”

Section: Discussionmentioning

confidence: 99%

“…Given the criticality of orofacial movements for a variety of fundamental genetic background; a novel system is applied to allow the resolution and quantification of individual orofacial movement topographies; and comparisons are made with our recent reports on these same parameters, assessed using identical methods by the same investigators, in congenic D 1 , D 2 and D 3 mutants, as described previously in detail (Tomiyama et al, , 2002. It should be emphasized that the present findings were conducted in male mutants.…”

Section: Discussionmentioning

confidence: 99%

“…A rapid time-sampling behavioural checklist technique, used previously to resolve the topography of general exploratory and DA agonist-induced behaviour in knockout mice in an ethologically-based, unrestricted paradigm Ross et al, 2000;McNamara et al, 2002McNamara et al, , 2003O'Sullivan et al, 2005), was applied similarly to resolve the topography of orofacial movement (Tomiyama et al, , 2002: each of five mice was observed sequentially for 5 s periods at 25 s intervals; for each mouse, the presence or absence of each individual element (occurring alone or in any combination) was determined in each of the 5 s periods. For assessment of orofacial movement topography and its habituation profile without drug challenge, assessments commenced immediately after placement in restrictors, and continued for 30 min periods over a total duration of 210 min; mice were used on a single occasion only.…”

Section: Assessment Of Orofacial Movement Topographymentioning

confidence: 99%

“…These difficulties are exacerbated by considerable controversy, based primarily on data in rats, as to how orofacial movements should be defined phenomenologically and resolved empirically; generic terms such as 'vacuous chewing' enjoy widespread usage despite uncertainty as to their relevance at a physiological level (Waddington, 1990;Waddington et al, 1998;Tomiyama et al, 2001Tomiyama et al, , 2002.…”

Section: Introductionmentioning

confidence: 99%

“…This has been applied to describe the phenotype of orofacial movements and topographical responses to D 1 -like and D 2 -like agonists in mice with congenic D 1 , D 2 and D 3 receptor 'knockout' (Tomiyama et al, 2002. We now describe the application of this technique to characterise topographically, in a complementary, comparative manner, the phenotype of orofacial movements, and responses to the D 1 -like agonist SK&F 83959 and the …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction ‘knockout’

Tomiyama

Makihara

Yamamoto

et al. 2006

European Neuropsychopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Orofacial Movement Topographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction ‘knockout’

Tomiyama

Makihara

Yamamoto

et al. 2006

European Neuropsychopharmacology

View full text Add to dashboard Cite

Comparative phenotypic resolution of spontaneous, D₂‐like and D₁‐like agonist‐induced orofacial movement topographies in congenic mutants with dopamine D₂ vs. D₃ receptor “knockout”

Tomiyama

McNamara

Clifford

et al. 2003

Synapse

View full text Add to dashboard Cite

Using a novel system, the role of D2-like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2 vs. D3 receptor knockout, and compared with findings in D1A mutants. Under spontaneous conditions, D2 mutants evidenced increased vertical jaw movements and unaltered horizontal jaw movements, with reductions in tongue protrusions and incisor chattering; in D3 mutants, only incisor chattering was reduced. Given previous evidence that D1A mutants show reduced horizontal but not vertical jaw movements, this indicates that apparent oppositional D1-like:D2-like interactions in the regulation of composited jaw movements may in fact reflect the independent actions of D2 receptors to inhibit vertical jaw movements and of D1A receptors to facilitate horizontal jaw movements. Effects of the D2-like agonist RU 24213 to exert greater reduction in horizontal than in vertical jaw movements were not altered prominently in either D2 or D3 mutants. The D1-like agonists A 68930 and SK&F 83959 induced vertical jaw movements, tongue protrusions, and incisor chattering; induction of tongue protrusions by A 68930 was reduced in D2 mutants. D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements.

show abstract

Orofacial movements in phospholipase C‐related catalytically inactive protein‐1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D₁ dopamine receptor agonist SKF 83959

Tomiyama

Song

Kobayashi

et al. 2010

Synapse

View full text Add to dashboard Cite

Orofacial movements are regulated by D(1)-like dopamine receptors interacting with additional mechanisms. Phospholipase C-related catalytically inactive protein (PRIP) regulates cell surface expression of GABA(A) receptors containing a gamma2 subunit. Mutant mice with double knockout of PRIP-1 and PRIP-2 were used to investigate aspects of GABAergic regulation of orofacial movements and interactions with D(1) mechanisms. Vertical jaw movements, tongue protrusions and movements of the head and vibrissae were reduced in PRIP-1/2 double knockouts. The GABA(A)ergic agent diazepam reduced movements of the head and vibrissae; these effects were unaltered in PRIP-1/2 double knockouts. The D(1)-like agonist SKF 83959 induced vertical jaw movements, incisor chattering, and movements of the head and vibrissae that were unaltered in PRIP-1/2 double knockouts. However, SKF 83959-induced tongue protrusions were reduced in PRIP-1/2 double knockouts. PRIP-mediated regulation of GABA(A)ergic receptor mechanisms influences topographically distinct aspects of orofacial movement and interacts with D(1) receptor systems.

show abstract

Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor ‘knockout’ mice

Cited by 30 publications

References 38 publications

Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction ‘knockout’

Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction ‘knockout’

Comparative phenotypic resolution of spontaneous, D₂‐like and D₁‐like agonist‐induced orofacial movement topographies in congenic mutants with dopamine D₂ vs. D₃ receptor “knockout”

Orofacial movements in phospholipase C‐related catalytically inactive protein‐1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D₁ dopamine receptor agonist SKF 83959

Contact Info

Product

Resources

About

Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor ‘knockout’ mice

Cited by 30 publications

References 38 publications

Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction ‘knockout’

Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction ‘knockout’

Comparative phenotypic resolution of spontaneous, D2‐like and D1‐like agonist‐induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor “knockout”

Orofacial movements in phospholipase C‐related catalytically inactive protein‐1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D1 dopamine receptor agonist SKF 83959

Contact Info

Product

Resources

About

Comparative phenotypic resolution of spontaneous, D₂‐like and D₁‐like agonist‐induced orofacial movement topographies in congenic mutants with dopamine D₂ vs. D₃ receptor “knockout”

Orofacial movements in phospholipase C‐related catalytically inactive protein‐1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D₁ dopamine receptor agonist SKF 83959