Phenotypical Conversions of Dermal Adipocytes as Pathophysiological Steps in Inflammatory Cutaneous Disorders

Kruglikov, Ilja L.; Zhang, Zhuzhen; Scherer, Philipp E.

doi:10.3390/ijms23073828

Cited by 6 publications

(2 citation statements)

References 81 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This transition results in the replacement of fibrosis with DWAT volume, causing an uneven skin structure and the formation of skin folds [61]. UV radiation induces the activation of the TGF-β signaling pathway, which contributes to the conversion of adipocytes to myofibroblasts, resulting in the depletion of DWAT [62].…”

Section: Skin Adipose Tissue Collapsementioning

confidence: 99%

Exosomes in skin photoaging: biological functions and therapeutic opportunity

Hajialiasgary Najafabadi,

Soheilifar,

Masoudi-Khoram

2024

Cell Commun Signal

View full text Add to dashboard Cite

Exosomes are tiny extracellular vesicles secreted by most cell types, which are filled with proteins, lipids, and nucleic acids (non-coding RNAs, mRNA, DNA), can be released by donor cells to subsequently modulate the function of recipient cells. Skin photoaging is the premature aging of the skin structures over time due to repeated exposure to ultraviolet (UV) which is evidenced by dyspigmentation, telangiectasias, roughness, rhytides, elastosis, and precancerous changes. Exosomes are associated with aging-related processes including, oxidative stress, inflammation, and senescence. Anti-aging features of exosomes have been implicated in various in vitro and pre-clinical studies. Stem cell-derived exosomes can restore skin physiological function and regenerate or rejuvenate damaged skin tissue through various mechanisms such as decreased expression of matrix metalloproteinase (MMP), increased collagen and elastin production, and modulation of intracellular signaling pathways as well as, intercellular communication. All these evidences are promising for the therapeutic potential of exosomes in skin photoaging. This review aims to investigate the molecular mechanisms and the effects of exosomes in photoaging.

show abstract

Section: Skin Adipose Tissue Collapsementioning

confidence: 99%

Exosomes in skin photoaging: biological functions and therapeutic opportunity

Hajialiasgary Najafabadi,

Soheilifar,

Masoudi-Khoram

2024

Cell Commun Signal

View full text Add to dashboard Cite

show abstract

“…Dermal fibroblasts produce collagen and elastin fibers comprising extracellular matrix (ECM), which provide strength and elasticity to the skin 3 . The deepest layer of the skin is the subcutaneous tissue, which encompasses adipocytes, mesenchymal stem cells (MSCs), and blood vessels 4 . Skin homeostasis depends on the complex and interconnected relationships among various skin cells, including keratinocytes, macrophages, melanocytes, fibroblasts, MSCs, and endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

Exosomes: The emerging mechanisms and potential clinical applications in dermatology

Yu,

Feng,

Zeng

et al. 2024

Int. J. Biol. Sci.

View full text Add to dashboard Cite

Skin tissue, composed of epidermis, dermis, and subcutaneous tissue, is the largest organ of the human body. It serves as a protective barrier against pathogens and physical trauma and plays a crucial role in maintaining homeostasis. Skin diseases, such as psoriasis, dermatitis, and vitiligo, are prevalent and can seriously impact the quality of patient life. Exosomes are lipid bilayer vesicles derived from multiple cells with conserved biomarkers and are important mediators of intercellular communication. Exosomes from skin cells, blood, and stem cells, are the main types of exosomes that are involved in modulating the skin microenvironment. The dysregulation of exosome occurrence and transmission, as well as alterations in their cargoes, are crucial in the complex pathogenesis of inflammatory and autoimmune skin diseases. Therefore, exosomes are promising diagnostic and therapeutic targets for skin diseases. Importantly, exogenous exosomes, derived from skin cells or stem cells, play a role in improving the skin environment and repairing damaged tissues by carrying various specific active substances and involving a variety of pathways. In the domain of clinical practice, exosomes have garnered attention as diagnostic biomarkers and prospective therapeutic agents for skin diseases, including psoriasis and vitiligo. Furthermore, clinical investigations have substantiated the regenerative efficacy of stem cell-derived exosomes in skin repair. In this review, we mainly summarize the latest studies about the mechanisms and applications of exosomes in dermatology, including psoriasis, atopic dermatitis, vitiligo, systemic lupus erythematosus, systemic sclerosis, diabetic wound healing, hypertrophic scar and keloid, and skin aging. This will provide a novel perspective of exosomes in the diagnosis and treatment of dermatosis.

show abstract

Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives

Sun

Scherer

2023

Comprehensive Physiology

View full text Add to dashboard Cite

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy expansion of adipose tissue in response to over nutrition. In obese adipose-depots, hypoxia stimulates multiple pro-fibrotic signaling pathways in different cell populations, thereby inducing the overproduction of the ECM components, including collagens, noncollagenous proteins, and additional enzymatic components of ECM synthesis. As a consequence, local fibrosis develops. The result of fibrosisinduced mechanical stress not only triggers cell necrosis and inflammation locally in adipose tissue but also leads to system-wide lipotoxicity and insulin resistance. A better understanding of the mechanisms underlying the obesity-induced fibrosis will help design therapeutic approaches to reduce or reverse the pathological changes associated with obese adipose tissue. Here, we aim to summarize the major advances in the field, which include newly identified fibrotic factors, cell populations that contribute to the fibrosis in adipose tissue, as well as novel mechanisms underlying the development of fibrosis. We further discuss the potential therapeutic strategies to target fibrosis in adipose tissue for the treatment of obesity-linked metabolic diseases and cancer.

show abstract

Phenotypical Conversions of Dermal Adipocytes as Pathophysiological Steps in Inflammatory Cutaneous Disorders

Cited by 6 publications

References 81 publications

Exosomes in skin photoaging: biological functions and therapeutic opportunity

Exosomes in skin photoaging: biological functions and therapeutic opportunity

Exosomes: The emerging mechanisms and potential clinical applications in dermatology

Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives

Contact Info

Product

Resources

About