Phenotypical Differences of Childhood- and Adult-Onset Atopic Dermatitis

Abstract

Self-reported adult-onset AD is common and has distinct phenotypes with lesional predilection for the hands and/or head/neck.

Burden of illness in adults with atopic dermatitis: Analysis of National Health and Wellness Survey data from France, Germany, Italy, Spain, and the United Kingdom

“…[1][2][3] AD usually first manifests in early infancy and childhood. 4,5 For about half of pediatric patients, however, AD persists into adulthood, 6,7 becoming a chronic, lifelong condition, 5 especially for patients with later-onset disease, or presenting with greater severity, or both. 8 AD can also initially appear in adulthood.…”

“…8 AD can also initially appear in adulthood. 7,[9][10][11] AD prevalence in adults varies according to severity, assessment method, and region. Limited AD prevalence data in European adults indicate prevalence rates between 4.4% and 7.1% (with a range between countries of 2.2%e17.6%) 12,13 and trends of increasing prevalence.…”

Comorbidities and the impact of atopic dermatitis

“…Atopic dermatitis is a heterogeneous disorder with variable lesional morphology (eg, erythema, lichenification, erosions, scaling, oozing/weeping, prurigo nodules), 6 distribution (eg, extent, head and neck, hands and feet 7 ), age of onset, 8,9 persistence, 10 symptoms (eg, itch, skin pain, 11 sleep disturbance 12e14 ). A recent global systematic review and meta-analysis of AD characteristics identified 78 different signs and symptoms of AD, with significant variability by global region and patient age.…”

Retrospective markers of paediatric atopic dermatitis persistence after hospital diagnosis: A nationwide cohort study

“…Atopic dermatitis (AD) is a common inflammatory skin condition that normally begins in early childhood and resolves before adolescence in up to 80% of cases . Two classes of persistent AD, that is early‐onset‐persistent and early‐onset‐late‐resolving, are both associated with filaggrin gene mutations, an increased AD genetic risk score, and a personal or parental history of atopy …”

“…1 Two classes of persistent AD, that is earlyonset-persistent and early-onset-late-resolving, are both associated with filaggrin gene mutations, an increased AD genetic risk score, and a personal or parental history of atopy. 2 A meta-analysis showed that about 20% of AD children experience persistent disease after 8 years, but only 5% after 20 years. 3 Recent studies confirm that it is difficult to study AD persistence properly since the disease is heterogeneous and recurrent.…”