Phenotyping myocardial injury related to COVID and SARS-CoV-2 vaccination: insights from cardiovascular magnetic resonance

Garg, R.; Hussain, Muzna; Friedrich, Matthias G.

doi:10.3389/fcvm.2023.1186556

Cited by 2 publications

(1 citation statement)

References 76 publications

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“…The highest risk for developing myocarditis has occurred in young men after receiving the second dose (50) Case reports of vaccination-associated myocarditis deaths have been published (35, 51), but, in large study settings, post vaccination myocarditis has rarely been associated with death (8, 10, 13, 50, 52). Notably, myocardial injury associated with a clinical diagnosis of myocarditis after COVID-19 vaccination has been reported mild, as reviewed by Garg et al (53). In the present study, forensic pathologist considered COVID-19 vaccination as contributory cause of death in two cases with type 1 diabetes mellitus and diabetic ketoacidosis.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination was a rare potential etiology for cause of death after medicolegal autopsy. A Finnish nationwide study

Pakanen,

Nieminen,

Kuvaja

et al. 2024

Preprint

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COVID-19 vaccinations began globally at the end of 2020. By the end of 2021, 9.8 million doses were given in Finland. Regarding safety, most vaccine-related adverse reactions have been mild, but serious and lethal ones have also occurred. Autopsies in post vaccination deaths may give insight to the extent of fatal health conditions with potential COVID-19 vaccine etiology and provide new hypotheses of possible causalities between vaccination and severe health conditions. We searched the complete documentation on all medicolegal autopsies in Finland between December 2020 and December 2021 to assess how often the basis for autopsy was a suspected fatal adverse reaction to COVID-19 vaccination, and whether vaccination remained a potential etiology for any health condition determined as a cause of death after the autopsy. We linked register-based data on individual COVID-19 vaccination course and pre-existing health conditions. We found 428 autopsy cases with a mention of COVID-19 vaccination, and prior to autopsy, vaccination was suspected to play a part in 76 deaths. Post autopsy, a forensic pathologist considered vaccination as a potential etiology in five underlying and seven contributory causes of death. These included seven thromboembolisms, two diabetic ketoacidoses, one myocarditis, one acute pancreatitis, and one eosinophilic granulomatosis with polyangiitis. In relation to the number of vaccinations within Finland, a suspicion of vaccine-related serious adverse reaction was rarely an indication for medicolegal autopsy. Even less frequently was vaccination considered to play a part in the process leading to death, although considerable doubt remains in the accuracy of individual considerations, and autopsy cannot definitively confirm causality between vaccination and death. Regarding vaccination safety, continuing evaluation of suspected vaccine-related deaths is essential, and an autopsy should be part of the investigation when such a suspicion arises.

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Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination was a rare potential etiology for cause of death after medicolegal autopsy. A Finnish nationwide study

Pakanen,

Nieminen,

Kuvaja

et al. 2024

Preprint

View full text Add to dashboard Cite

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The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage

Rostami,

Farahani,

Esmaelian

et al. 2024

Stem Cell Rev and Rep

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Phenotyping myocardial injury related to COVID and SARS-CoV-2 vaccination: insights from cardiovascular magnetic resonance

Abstract: Clinical presentationMyocardial injury is typically characterized by chest pain, dyspnea and palpitations, with or without elevated cardiac biomarkers such as high-sensitivity cardiac troponin (hsTn) and/

Cited by 2 publications

References 76 publications

COVID-19 vaccination was a rare potential etiology for cause of death after medicolegal autopsy. A Finnish nationwide study

COVID-19 vaccination was a rare potential etiology for cause of death after medicolegal autopsy. A Finnish nationwide study

The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage

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