Phenotyping of ex vivo propagated graft-infiltrating cells—A tool to monitor rejection in the early post-operative period

T cell receptor and CD3 antibody crossreactivity opens new research and veterinary medicine opportunities

“…Furthermore, the CD3 molecular complex consists of non‐covalently associated proteins that are co‐expressed with the TCR on the surface of T cells and provides the signaling machinery to transduce signals that drive growth and differentiation (6, 7). The ability to identify this lymphocyte population has important implications in human patients for diagnosing infectious diseases (8, 9), monitoring the status of organ transplants (10), and tracking the progress of hematopoietic reconstitution following bone marrow transplantation (11). Currently, there is a wide selection of commercially available antibodies directed against both TCR and CD3 for human, mouse, rat and chicken T cells.…”