2022
DOI: 10.3390/biomedicines10102562
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Phenotyping Post-COVID Pain as a Nociceptive, Neuropathic, or Nociplastic Pain Condition

Abstract: Pain after an acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) condition (post-COVID pain) is becoming a new healthcare emergency. Precision medicine refers to an evidence-based method of grouping patients based on their diagnostic/symptom presentation and then tailoring specific treatments accordingly. Evidence suggests that post-COVID pain can be categorized as nociceptive (i.e., pain attributable to the activation of the peripheral receptiv… Show more

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Cited by 32 publications
(38 citation statements)
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“…But from 2013 to the present, the number of published articles has increased by leaps and bounds. Among the total of 867 literatures, only five clinical studies are identified ( Huang et al, 2017 ; Mathias et al, 2017 ; Li et al, 2020 ; Fernandez-de-las-Penas et al, 2022 ; Stenz et al, 2022 ). Most of them focus on peripheral NP to search for potential epigenetic markers.…”
Section: Discussionmentioning
confidence: 99%
“…But from 2013 to the present, the number of published articles has increased by leaps and bounds. Among the total of 867 literatures, only five clinical studies are identified ( Huang et al, 2017 ; Mathias et al, 2017 ; Li et al, 2020 ; Fernandez-de-las-Penas et al, 2022 ; Stenz et al, 2022 ). Most of them focus on peripheral NP to search for potential epigenetic markers.…”
Section: Discussionmentioning
confidence: 99%
“…Although preliminary due to the low number of participants and no external validation, clustering analysis identified that 33% of patients demonstrated a central sensitization profile featuring a high CSI score, nociceptive pain facilitation, and malfunctioning of the nociceptive inhibitory pathways. This subgroup of patients fulfills all of the criteria for a nociplastic condition [ 55 ] as has been proposed recently [ 56 ] and this could need particular attention in their management. For instance, early treatment of these subgroups of patients could be applied to avoid the further development of central sensitization.…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, it may be most productive to determine the most predominant pain phenotype instead of just statically classifying a patient into just one phenotype. Fernández-de-las-Peñas et al have recently proposed the application of the International Association (IASP) clinical criteria/a grading system for clinical identification of nociplastic pain (Kosek et al, 2021) for phenotyping post-COVID pain (Fernández-de-las-Peñas, Nijs, Neblett, Polli, et al, 2022). In this section, the most relevant points of this classification will be briefly discussed.…”
Section: Painmentioning
confidence: 99%