Phentolamine inhibits angiogenesis in vitro: Suppression of proliferation migration and differentiation of human endothelial cells

Pan, Liangli; Liu, Chenyang; Kong, Yanan; Zhong-yu, Piao

doi:10.3233/ch-162070

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Naftopidil induced apoptosis via activation of caspase-3 in bladder cancer cells and reduced xenograft tumor growth in vivo [116,117]. The α1 AR antagonist phentolamine also blocked angiogenesis [118]. Taking α1 blockers was shown to reduce the incidence of bladder cancer in a retrospective observational study of 27,813 male patients (some of whom were prescribed α1 AR blockers for hypertension or benign prostate hyperplasia).…”

Section: Do Neurons Support Cancer Growth And/or Inhibit It?mentioning

confidence: 99%

The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy

Patwardhan,

Mahendran

2023

IJMS

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The tumor microenvironment (TME) is complex and involves many different cell types that seemingly work together in helping cancer cells evade immune monitoring and survive therapy. The advent of single-cell sequencing has greatly increased our knowledge of the cell types present in the tumor microenvironment and their role in the developing cancer. This, coupled with clinical data showing that cancer development and the response to therapy may be influenced by drugs that indirectly influence the tumor environment, highlights the need to better understand how the cells present in the TME work together. This review looks at the different cell types (cancer cells, cancer stem cells, endothelial cells, pericytes, adipose cells, cancer-associated fibroblasts, and neuronal cells) in the bladder tumor microenvironment. Their impact on immune activation and on shaping the microenvironment are discussed as well as the effects of hypertensive drugs and anesthetics on bladder cancer.

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Section: Do Neurons Support Cancer Growth And/or Inhibit It?mentioning

confidence: 99%

The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy

Patwardhan,

Mahendran

2023

IJMS

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“…Endothelial progenitor cells (EPCs) express β 2 ARs [15]. Human dermal microvascular endothelial cells express all subtypes of β ARs [13], while human retinal endothelial cells express both β 1 and β 3 but not β 2 ARs [16].…”

Section: Expression Of Ars In Endothelial Cellsmentioning

confidence: 99%

A Systematic Review on the Role of Adrenergic Receptors in Angiogenesis Regulation in Health and Disease

Xanthopoulos¹,

Daskalopoulou²,

Frountzi³

et al. 2021

IJTM

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Angiogenesis is essential during development or when tissue restoration and oxygenation is required. Limited or excessive formation of blood vessels is a hallmark of several pathologies, and many angiogenesis-related pathways are being studied to highlight potential targets for effective angiogenesis-stimulating or inhibiting therapeutic approaches. A few studies point to the adrenergic system as a significant regulator of angiogenesis, directly or indirectly. Functional adrenergic receptors are expressed on endothelial cells and affect their response to the adrenergic system. The latter can also upregulate the release of growth factors by mural cells of the vessel wall, blood cells or cancer cells, thus subsequently affecting endothelial cell functions and angiogenesis. In the present study we summarize up-to-date literature on the known effects of the adrenergic receptors on physiological and pathological angiogenesis.

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“…We have tested various concentrations of epinephrine (E) and norepinephrine (NE) purchased from Sigma, on the A375 cell line proliferation capacity. Specific inhibitors yohimbine (Y), propranolol (Pro) and phentolamine (Ph) were purchased from Sigma and used in concentrations prior established [27][28][29].…”

Section: Lactate Dehydrogenase (Ldh) Test Used Cytotox 96mentioning

confidence: 99%

Adrenergic Modulation of Melanoma Cells Proliferation

Surcel¹

2018

FARMACIA

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Investigation of the complex cellular and molecular mechanisms underlying cutaneous melanoma development is of major interest in biomedical research. Within our study we have developed an in vitro experimental system using A375 human melanoma cell line to investigate the impact of adrenergic modulation in melanoma. Thus, we have studied the proliferative effect of norepinephrine and epinephrine in the absence and presence of several specific inhibitors. We have found that the pro-proliferative action of norepinephrine and epinephrine can be overridden by certain inhibitors. Moreover, for some of the inhibitors, membrane integrity hindering is associated with the actual decrease in the proliferative capacity of the tumoral cells. Our study continues a series of experimental data that shows neurotransmitters to be involved in the proliferation of melanoma cells and opens new research pathways for further therapeutic approaches in this field. RezumatInvestigarea mecanismelor complexe moleculare și celulare care stau la baza tumorigenezei în melanomul cutanat prezintă un interes major în cercetarea biomedicală. În studiul nostru a fost dezvoltat un sistem experimental in vitro utilizând linia celulară de melanom uman A375 pentru investigarea efectului modulării adrenergice în melanom. A fost studiat efectul indus asupra capacității proliferative a celulelor tumorale de către adrenalină și noradrenalină în absența și prezența unor inhibitori specifici. Am observat că acțiunea pro-proliferativă a adrenalinei și noradrenalinei poate fi contracarată de o serie de inhibitori. Afectarea integrității membranei celulare este asociată cu scăderea capacității proliferative a celulelor tumorale în cazul unora dintre inhibitorii studiați. Studiul nostru continuă o serie de date experimentale obținute care prezintă implicarea neurotransmițătorilor în proliferarea celulelor de melanom și deschide astfel noi domenii de cercetare pentru identificarea unor noi metodologii terapeutice.

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Phentolamine inhibits angiogenesis in vitro: Suppression of proliferation migration and differentiation of human endothelial cells

Cited by 6 publications

References 29 publications

The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy

The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy

A Systematic Review on the Role of Adrenergic Receptors in Angiogenesis Regulation in Health and Disease

Adrenergic Modulation of Melanoma Cells Proliferation

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