Phentolamine mesylate: It′s role as a reversal agent for unwarranted prolonged local analgesia

Grover, Harpreet Singh; Gupta, Anil; Saksena, Neha; Saini, Neha

doi:10.4103/0970-4388.165646

Cited by 8 publications

(3 citation statements)

References 1 publication

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“…The present preliminary clinical trial study was designed to evaluate the efficacy of photobiomodulation in reversal of soft-tissue local anesthesia. In a previous study, this was achieved by injection of phentolamine mesylate, and novel LLLT therapy might be considered as a non-invasive treatment adjunct to local anesthesia [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Recovery of Local Anesthesia in Pediatric Patients: The Impact of Photobiomodulation on Reversing Anesthesia Effects

Olszewska,

Matys,

Grzech-Leśniak

et al. 2024

Med Sci Monit

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Background The split-mouth study design is used in oral health research and usually consists of 2 treatments randomly assigned to either the right or left side. This split-mouth study aimed to evaluate the efficacy of photobiomodulation on reversal of local anesthesia in 50 children aged 8–10 years. Material/Methods The study was conducted among 50 children: 27 girls and 23 boys, aged 8–10 years (mean age 9.38±1.15 years), who presented 2 carious maxillary permanent molars. One side was randomly assigned to the laser group (50 teeth), and the contralateral side to the control group (50 teeth). At the end of the treatment, photobiomodulation (PBM) was performed in the area of infiltration at 6 points, with 635 nm (25 children) (250 mW, 500 mW/cm 2 , 15J) and 808 nm (25 children) (200 mW, 400 mW/cm 2 , 12J) (SmartM PRO, Lasotronix, Poland). On the contralateral side, the laser’s off-mode applicator was used. Anesthetic effect was evaluated by palpation test (soft tissues) and electrical test (dental pulp). Results After 15 minutes, in the laser group the return to normal sensations in the palpation test showed 88% (808 nm) and 68% (635 nm), and only 20% in the control group ( P =0.04123). After 45 minutes, all the participants from the PBM group returned to normal sensations ( P =0.21458). Dental pulp’s excitability threshold was lower for both wavelengths compared to the control group ( P =0.000001). Conclusions The identification of factors accelerating the recovery time to normal function, such as PBM, can be used as important data to eliminate self-injury secondary to local anesthesia (LA) in children.

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Section: Discussionmentioning

confidence: 99%

Enhanced Recovery of Local Anesthesia in Pediatric Patients: The Impact of Photobiomodulation on Reversing Anesthesia Effects

Olszewska,

Matys,

Grzech-Leśniak

et al. 2024

Med Sci Monit

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“…PM is a non-specific α-adrenergic inhibitor whose effect is vasodilation of the vascular system [7,8,11,17]. It inhibits the ability of sympathomimetic amines, such as norepinephrine and epinephrine, to stimulate vascular contraction [19,20]. Given that it is an α-adrenergic inhibitor, special attention should be paid to any cardiovascular changes that may occur, such as hypotension and/or tachycardia following the injection [9].…”

Section: Introductionmentioning

confidence: 99%

Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes

Vintanel-Moreno

Martı́nez-González

Martínez-Rodríguez

et al. 2021

JCM

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The clinical application of phentolamine mesylate (PM) as an anaesthetic reversal agent has been documented in the paediatric population and in conservative dentistry, but no studies have been conducted regarding dental implant surgery. A prospective randomised study was conducted on 60 patients eligible for mandibular implant treatment, randomly divided between a control group (CG) and an experimental group (EG), to whom PM was administered. Haemodynamic changes, adverse effects and patient satisfaction were assessed. No statistically significant differences in haemodynamic changes and postoperative pain were found between CG and EG (p < 0.05), except for systolic blood pressure (SBP), which increased slightly in EG, without posing a risk to patients. There were no differences in the occurrence of adverse effects between the two groups, except for greater difficulty in chewing and biting (p < 0.05) in CG and greater pain in the injection area (p = 0.043) in EG. Among EG patients, 83.3% reported that they would request PM again for future dental treatment. The use of PM offers an alternative to implant surgery, thereby increasing patients’ quality of life without increasing the risks.

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“…PM is a non-specific α-adrenergic inhibitor whose effect is vasodilation of the vascular system [7,8,11,17]. It acts by inhibiting the ability of sympathomimetic amines, such as norepinephrine and epinephrine, to stimulate vascular contraction [19,20]. Because it is an α-adrenergic inhibitor, special attention should be paid to any cardiovascular changes that may occur, such as hypotension and/or tachycardia after injection [9].…”

Section: Introductionmentioning

confidence: 99%

Use of Phentolamine Mesylate in Implant Surgery. Analysis of Adverse Effects and Haemodynamic Changes

Vintanel-Moreno¹,

Martı́nez-González²,

Martínez-Rodríguez³

et al. 2021

Preprint

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The clinical application of Phentolamine Mesylate (PM) as an anaesthetic reversal agent has been documented in paediatric patients and in conservative dentistry, but no studies have been found in implant surgery. A prospective randomised study was conducted in 60 patients eligible for mandibular implant treatment, randomly divided between the Control Group (CG) and Experimental Group (EG), who were administered PM. Haemodynamic changes, adverse effects and patient satisfaction were assessed. No statistically significant differences in haemodynamic changes and postoperative pain were found between CG and EG (p&lt;0.05), except for Systolic Blood Pressure (SBP) which increased slightly in EG, without posing a risk to the patient. There were no differences in the presence of adverse effects between the two groups, except in the CG which presented greater difficulty in chewing and biting (p&lt;0.05) and the EG with greater pain in the injection area (p=0.043). 83.3% of the EG patients would request PM again for future dental treatment. The use of PM offers an alternative in implant surgery, without increasing the risks and increasing the patient's quality of life.

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Phentolamine mesylate: It′s role as a reversal agent for unwarranted prolonged local analgesia

Cited by 8 publications

References 1 publication

Enhanced Recovery of Local Anesthesia in Pediatric Patients: The Impact of Photobiomodulation on Reversing Anesthesia Effects

Enhanced Recovery of Local Anesthesia in Pediatric Patients: The Impact of Photobiomodulation on Reversing Anesthesia Effects

Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes

Use of Phentolamine Mesylate in Implant Surgery. Analysis of Adverse Effects and Haemodynamic Changes

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