Phenylalanine-based poly(ester urea)s composite films with nitric oxide-releasing capability for anti-biofilm and infected wound healing applications

Self-organization of zinc ions with a photosensitizer in vivo for enhanced antibiofilm and infected wound healing

“…The level of IL-6 is a predictor of inflammation and the severity of infection. 52 Prolonged high levels of IL-1β can hinder wound tissue remodeling, and high levels of TNF-α can produce cytotoxicity. 5 Therefore, it is crucial to control the increase of inflammatory factors in vivo .…”

Construction of multifunctional wound dressings with their application in chronic wound treatment

“…The prepared scaffold had good biocompatibility and could continuously and stably release nitric oxide within 360 h (total concentration of 1.15 μmol L −1 ), thereby stimulating the proliferation of fibroblasts and promoting the synthesis of collagen. 109 The use of dressings can provide a stable carrier for reactive gases such as oxygen and nitric oxide, which has a certain positive effect on the healing of chronic wounds. However, reducing the escape of gas and improving the efficiency of active gas delivery to the wound site remain a challenge, given the bare environment in which the dressing is applied in practice.…”

Special Features of Polyester-Based Materials for Medical Applications

“…Immunomodulatory properties toward skin keratinocytes in vitro were related in the case of olive leaf extract (OLE) incorporation in poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and PHB/poly(hydroxyoctanoate-co-hydroxydecanoate) (PHB/PHOHD) nanofibers, due to the antioxidant activity of oleuropein [ 175 ]. An antibacterial and antibiofilm dressing for wound healing was developed based on L-tryptophan and L-phenylalanine-based poly(ester urea)s electrospun fibers, which aimed at delivery of nitric oxide (NO), promoting proliferation, enhancing collagen, and accelerating wound treatment [ 176 , 177 ].…”