Phenylalanine-free taste-masked orodispersible tablets of fexofenadine hydrochloride: development,in vitroevaluation andin vivoestimation of the drug pharmacokinetics in healthy human volunteers

Abstract

Based on gustatory sensation test, FXD-CS (1:1) and FXD-ALG (1:0.5) SDs were selected. Taste-masked FXD-ODTs had appropriate physicochemical properties. Drug release profiles of F23 and the phenylalanine-containing Allegra(®) ODT were similar (f(2) = 96). Pores were observed following camphor sublimation. The pharmacokinetic studies proved F23 ability to increase extent of FXD absorption and reduce T(max).

Enhancement of the Oral Bioavailability of Fexofenadine Hydrochloride via Cremophor® El-Based Liquisolid Tablets

“…values of ten tablets. 10 The tablet friability test was conducted, on a weighed sample of twenty tablets, using a Rochetype friabilator (FAB-2, Logan Instruments Corp., NJ, USA) revolving at a speed of 25 rpm. By the end of 4 min, the tablets were dedusted, reweighed and the percentage loss in weight was related to the original sample weight.…”

“…values of three tablets. 10 For setting a level of comparison between formulae, the drug released percentage (DR%) and the dissolution efficiency percentage (DE%) after 5 minutes from the beginning of the dissolution studies were estimated. The latter was calculated according to Equation 6 proposed by Khan 28 as follows;…”

“…The investigated HPLC procedure for the determination of FXD was previously adopted for the estimation of FXD following administration of FXD orodispersible tablets in healthy volunteers. 10 To summarize, the mobile phase was a mixture of methanol and potassium dihydrogen phosphate (0.7% (w/v) (70: 30, v/v). The pH (3.5) of the latter solution was adjusted using phosphoric acid.…”

“…Various techniques were explored to enhance the solubility and dissolution properties of such drugs including; micronization of drugs, 1 development of various nanobased systems, 2 use of solid dispersions, 3 addition of surfactants and co-surfactants, 4 changing the drug to an amorphous state, 5 development of inclusion complexes with cyclodextrins, 6 use of pro-drug and drug derivatization, 7 dispersion in a porous matrix, 8 loading on carriers having high surface area, 9 development of orodispersible tablets via incorporation of superdisintegrants or sublimable agents. 10 The liquisolid compaction technique was developed, as another promising approach, by Spireas et al for promoting the dissolution characteristics of prednisolone 11 and hydrocortisone. 12 The liquisolid compacts are regarded as acceptably flowing and compressible powdered forms of a liquid medication.…”

Development and Characterization of PLGA Nanoparticle-Laden Hydrogels for Sustained Ocular Delivery of Norfloxacin in the Treatment of Pseudomonas Keratitis: An Experimental Study

“…values of the drug percentages released were plotted vs time. 27 The drug percentages released after 30 min (Q 30min ) and 12 hours (Q 12h ) were calculated. Parallel in vitro drug release studies of an aqueous NFX suspension (0.3%) were conducted to investigate the potential of NPs.…”