Phenylalanine transfer across the isolated perfused human placenta: an experimental and modeling investigation

Lofthouse, Emma M.; Perazzolo, Simone; Brooks, Susanne; Crocker, Ian; Glazier, Jocelyn D.; Johnstone, Edward; Panitchob, Nuttanont; Sibley, Colin P.; Widdows, Kate; Sengers, Bram G.; Lewis, Rohan M.

doi:10.1152/ajpregu.00405.2015

Cited by 17 publications

(15 citation statements)

References 33 publications

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“…Compartmental modeling has provided insight into the placental transfer of amino acids, in particular by highlighting the role of amino acid metabolism (23)(24)(25). Similarly, mathematical modeling could help interpret the factors that affect fatty acid transfer because it is currently not clear which of these is rate determining.…”

Section: Uptake and Delivery Mass Balancementioning

confidence: 99%

The influence of placental metabolism on fatty acid transfer to the fetus

Perazzolo

Hirschmugl

Wadsack

et al. 2017

Journal of Lipid Research

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Section: Uptake and Delivery Mass Balancementioning

confidence: 99%

The influence of placental metabolism on fatty acid transfer to the fetus

Perazzolo

Hirschmugl

Wadsack

et al. 2017

Journal of Lipid Research

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“…The influence of the maternal and fetal blood flows on the transport of substances has been reported previously [2, 3]. …”

Section: Introductionmentioning

confidence: 95%

Villous Tree Model with Active Contractions for Estimating Blood Flow Conditions in the Human Placenta

Kato

Oyen

Burton

2017

Open Biomed. Eng. J.

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Background:In the human placenta, maternal and fetal bloods exchange substances through the surface of the villous trees: the fetal blood circulates in the villous trees, around which the maternal blood circulates. The blood flows directly influence fetal growth. Stem villi, the main supports of the villous tree, have contractile cells along the axes, whose contractions are expected to influence the blood circulations in the placenta. The displacement is neither measurable nor predictable while non-invasive measurements such as umbilical Doppler waveforms are helpful to predict the histological changes of the villous trees and vascularization in the placenta.Objective:The displacement caused by the contraction of the villous tree is necessary to predict the blood flows in the placenta. Hence, a computational villous tree model, which actively contracts, was developed in this study.Method:The villous tree model was based on the previous reports: shear moduli of the human placenta; branching patterns in the stem villi. The displacement pattern in the placenta was estimated by the computational model when the shear elastic moduli were changed.Results:The results show that the displacement caused by the contraction was influenced by the shear elastic moduli, but kept useful for the blood flows in the placenta. The characteristics agreed with the robustness of the blood flows in the placenta.Conclusion:The villous tree model, which actively contracts, was developed in this study. The combination of this computational model and non-invasive measurements will be useful to evaluate the condition of the placenta.

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“…, ; Lofthouse et al . ). Placental amino acid transfer can be measured experimentally in the perfused placenta (Cleal et al .…”

Section: Introductionmentioning

confidence: 97%

“…The effect of maternal and fetal blood flow on placental phenylalanine transfer has been studied in the isolated perfused placenta (Lofthouse et al . ). Neither maternal nor fetal flow was found to be limiting for amino acid transfer within the range of flows tested.…”

Section: Introductionmentioning

confidence: 97%

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A systems perspective on placental amino acid transport

Cleal

Lofthouse

Sengers

et al. 2018

The Journal of Physiology

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Placental amino acid transfer is a complex process that is essential for fetal development. Impaired amino acid transfer causes fetal growth restriction, which may have lifelong health consequences. Transepithelial transfer of amino acids across the placental syncytiotrophoblast requires accumulative, exchange and facilitated transporters on the apical and basal membranes to work in concert. However, transporters alone do not determine amino acid transfer and factors that affect substrate availability, such as blood flow and metabolism, may also become rate‐limiting for transfer. In order to determine the rate‐limiting processes, it is necessary to take a systems approach which recognises the interdependence of these processes. New technologies have the potential to deliver targeted interventions to the placenta and help poorly growing fetuses. While many factors are necessary for amino acid transfer, novel therapies need to target the rate‐limiting factors if they are going to be effective. This review will outline the factors which determine amino acid transfer and describe how they become interdependent. It will also highlight the role of computational modelling as a tool to understand this process.

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Phenylalanine transfer across the isolated perfused human placenta: an experimental and modeling investigation

Cited by 17 publications

References 33 publications

The influence of placental metabolism on fatty acid transfer to the fetus

The influence of placental metabolism on fatty acid transfer to the fetus

Villous Tree Model with Active Contractions for Estimating Blood Flow Conditions in the Human Placenta

A systems perspective on placental amino acid transport

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