Phenylephrine‐induced neurogenic prostatitis facilitates the promotion of PIN‐like lesions in rats

Rosenzweig, N Lesavre; Horodniceanu, J.; Abramovici, Armand

doi:10.1002/pros.10355

Cited by 6 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies showed that phenylephrine treatment induced atypical prostatic hyperplasia and mild fibrosis in the rat ventral prostate (Golomb et al, 1998;Rosenzweig et al, 2004;Rosenzweig-Bublil and Abramovici, 2006). These effects have been related to a tissue repair process occurring subsequent to the inflammatory exudates that takes place during early period of phenylephrine treatment.…”

Section: Discussionmentioning

confidence: 94%

Fibrosis-related gene expression in the prostate is modulated by doxazosin treatment

et al. 2012

View full text Add to dashboard Cite

Our data suggest that relaxation of smooth muscle cells by alpha-blockers interferes with the mechanical dynamics of the prostatic stroma extracellular matrix components, generating a pro-fibrotic effect probably via the TGF-beta 1 signaling pathway. Long term treatment with doxazosin may also lead to a reduced turnover of extracellular matrix components. Our results add to a better understanding of the molecular mechanisms behind the effects of alpha-blockade on prostatic histoarchitecture and the response to treatment for benign prostatic hyperplasia.

show abstract

Section: Discussionmentioning

confidence: 94%

Fibrosis-related gene expression in the prostate is modulated by doxazosin treatment

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Growing data displayed the SNS played a role in prostatic disease. Previous reports have shown that continuous exogenic sympathetic stimulation by phenylephrine promotes a biphasic effect on the rat ventral prostate [27] in which a first inflammatory reaction took place at 3-8 h after injection and proliferative changes occurred on the 7th day. Continuous endogenous sympathetic overloading in genetically hypertensive rats was accompanied by spontaneous hyperplasia of the prostate of old rats [28] ; this had also taken place in hypertensive patients [29] .…”

Section: Discussionmentioning

confidence: 99%

Sympathetic Nervous System Overactivity in the Wistar Rat with Proliferative Lesions of Ventral Prostate Induced by Chronic Stress

Huang

Fang²,

Meng³

et al. 2009

Urol Int

View full text Add to dashboard Cite

Objectives: The sympathetic nervous system and hypothalamic-pituitary-adrenal axis have been known to be reactive to psychological factors such as stress in which several humoral factors are released. Growing data suggest that stress conditions could be associated with the development or aggravation of prostatic disease. The present study aims to investigate the influence of chronic stress and blockade of the sympathetic nerve on rat prostate. Methods: We used 2 weeks of restraint water-immersion stress to induce a chronic psychological stress model of Wistar rats. Denervation of the peripheral sympathetic nerve was done by 6-hydroxydopamine (6-OHDA). Blood flow of ventral prostate, plasma catecholamine and cortisol were measured at the end of the experiment. The weight and secretions of dissected prostate lobes were measured and histology was performed by hematoxylin and eosin stain. Results: After 14 days of stress, the blood flow of ventral prostate decreased and plasma cortisol increased. The apparent proliferation of epithelium of ventral lobes were observed and dorsolateral ones were almost unaffected. On the other hand, the hyperplasia changes were not seen after the chemical sympathectomy had been done during stress. Conclusions: Chronic stress may lead to hyperplasia of ventral prostate, the overactivity of sympathetic nervous system is involved in the pathogenesis of prostatic disease.

show abstract

“…This effect is cell density-dependent, and the authors focused attention on the role of intercellular communication in coordinating the differentiation pathways. Furthermore, in an animal model, subchronic NA stimulation exerts a biphasic time-related effect on rat ventral prostate: a primary inflammatory response characterized by edema and by large-scale leukocyte infiltration, followed by a secondary proliferative phase involving both the acinar epithelium and the stromal component [51].…”

Section: The Role Of Catecholaminesmentioning

confidence: 99%

The role of the prostatic stroma in chronic prostatitis/chronic pelvic pain syndrome

et al. 2009

View full text Add to dashboard Cite

show abstract

Phenylephrine‐induced neurogenic prostatitis facilitates the promotion of PIN‐like lesions in rats

Abstract: Neuro-immune interactions promote prostatic fibrosis and dysplastic changes; these being preceded by an acute and transient inflammatory reaction.

Cited by 6 publications

References 30 publications

Fibrosis-related gene expression in the prostate is modulated by doxazosin treatment

Fibrosis-related gene expression in the prostate is modulated by doxazosin treatment

Sympathetic Nervous System Overactivity in the Wistar Rat with Proliferative Lesions of Ventral Prostate Induced by Chronic Stress

The role of the prostatic stroma in chronic prostatitis/chronic pelvic pain syndrome

Contact Info

Product

Resources

About