Phenylpropanoids from the leaves of<i>Acanthopanax koreanum</i>and their antioxidant activity

Nhiệm, Nguyễn Xuân; Kim, Ki Cheon; Kim, Areum-Daseul; Hyun, Jin Won; Kang, Hee Kyoung; Kiệm, Phan Văn; Minh, Châu Văn; Thu, Vu Kim; Tài, Bùi Hữu; Kim, Jeong Ah; Kim, Young Ho

doi:10.1080/10286020.2010.525743

Cited by 20 publications

(8 citation statements)

References 6 publications

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“…Compounds 3 and 4 were identified as quercetin 3-O-rutinoside [5] and isorhamnetin 3-Orutinoside [6], respectively, based on spectral evidences, which were in agreement with those of the reported data in literature. [4], *overlapped signal.…”

Section: Hepatocyte Protection Assaysupporting

confidence: 90%

Hepatoprotective Effects of Phenolic Glycosides From the Methanol Extract of Physalis Angulata

Anh¹,

Dung²,

Tuan

et al. 2017

JST

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By various chromatographic separations, four phenolic glycosides, methyl salicylate 2-O-triglycoside (1), icariside E5 (2), quercetin 3-O-rutinoside (3), and isorhamnetin 3-O-rutinoside (4) were isolated from the methanol extract of the whole plant of Physalis angulata. Their structures were determined by 1D-, 2D-NMR spectroscopic analyses and in comparison with the reported data. Compounds 3 exhibited significantly hepatoprotective activity with an EC50 value of 17.08 µg/mL. This is the first report of 1-4 from Physalis angulata.

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Section: Hepatocyte Protection Assaysupporting

confidence: 90%

Hepatoprotective Effects of Phenolic Glycosides From the Methanol Extract of Physalis Angulata

Anh¹,

Dung²,

Tuan

et al. 2017

JST

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“…The comparison of the NMR spectra of compound 8 with literature data (Nhiem et al, 2011) led to its identification as a monoterpene glycoside (4S)-a-terpineol 8-O-b-D-glucopyranoside, isolated earlier from Acanthopanax koreanum. Similarly, on the basis of analysis of NMR and specific optical rotation data ( [a] D 20 À38°(c 0.1, MeOH)), compound 9 was identified as icariside B 6 (7(8)-dihydro-b-ionone 3-O-b-D-glucopyranoside), isolated earlier from the aqueous extract of Epimedium grandiflorum (Miyase et al, 1988).…”

Section: Resultsmentioning

confidence: 97%

Structures of eremophilane-type sesquiterpene glucosides, alticolosides A–G, from the Far Eastern endemic Ligularia alticola Worosch

et al. 2015

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“…Compound 2 is commonly known as α-terpineol-β-D-O-glucopyranoside or α-terpinyl-β-glucoside. Nhiem et al [31] isolated this compound from a methanol extract of Acanthopanax koreanum leaves, although it did not possess antioxidant activity. This compound is also found in other plant parts such as apricot fruits [29], sweet potatoes [30], the aerial parts of Ligularia alticola [32], and an ethyl acetate extract of Saccocalyx satureioides [33].…”

Section: Discussionmentioning

confidence: 99%

Characterization of α-Glucosidase Inhibitors from Psychotria malayana Jack Leaves Extract Using LC-MS-Based Multivariate Data Analysis and In-Silico Molecular Docking

et al. 2020

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Psychotria malayana Jack has traditionally been used to treat diabetes. Despite its potential, the scientific proof in relation to this plant is still lacking. Thus, the present study aimed to investigate the α-glucosidase inhibitors in P.malayana leaf extracts using a metabolomics approach and to elucidate the ligand–protein interactions through in silico techniques. The plant leaves were extracted with methanol and water at five various ratios (100, 75, 50, 25 and 0% v/v; water–methanol). Each extract was tested for α-glucosidase inhibition, followed by analysis using liquid chromatography tandem to mass spectrometry. The data were further subjected to multivariate data analysis by means of an orthogonal partial least square in order to correlate the chemical profile and the bioactivity. The loading plots revealed that the m/z signals correspond to the activity of α-glucosidase inhibitors, which led to the identification of three putative bioactive compounds, namely 5′-hydroxymethyl-1′-(1, 2, 3, 9-tetrahydro-pyrrolo (2, 1-b) quinazolin-1-yl)-heptan-1′-one (1), α-terpinyl-β-glucoside (2), and machaeridiol-A (3). Molecular docking of the identified inhibitors was performed using Auto Dock Vina software against the crystal structure of Saccharomyces cerevisiae isomaltase (Protein Data Bank code: 3A4A). Four hydrogen bonds were detected in the docked complex, involving several residues, namely ASP352, ARG213, ARG442, GLU277, GLN279, HIE280, and GLU411. Compound 1, 2, and 3 showed binding affinity values of −8.3, −7.6, and −10.0 kcal/mol, respectively, which indicate the good binding ability of the compounds towards the enzyme when compared to that of quercetin, a known α-glucosidase inhibitor. The three identified compounds that showed potential binding affinity towards the enzymatic protein in molecular docking interactions could be the bioactive compounds associated with the traditional use of this plant.

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Phenylpropanoids from the leaves ofAcanthopanax koreanumand their antioxidant activity

Cited by 20 publications

References 6 publications

Hepatoprotective Effects of Phenolic Glycosides From the Methanol Extract of Physalis Angulata

Hepatoprotective Effects of Phenolic Glycosides From the Methanol Extract of Physalis Angulata

Structures of eremophilane-type sesquiterpene glucosides, alticolosides A–G, from the Far Eastern endemic Ligularia alticola Worosch

Characterization of α-Glucosidase Inhibitors from Psychotria malayana Jack Leaves Extract Using LC-MS-Based Multivariate Data Analysis and In-Silico Molecular Docking

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