Phenylpropanolamine in treatment of female stress urinary incontinence Double-blind placebo controlled study in 24 patients

Effect of Combined Treatment with Phenylpropanolamine and Estriol, Compared with Estriol Treatment Alone, in Postmenopausal Women with Stress Urinary Incontinence

“…The significant increase in MUCP can most probably be ascribed to phenylpropanolamine, as it was registered not only after combined treatment compared to pretreat ment values but also compared to treatment with estriol alone, which agrees with the findings by Kinn and Linds kog [24] and also with the registered urodynamic effects of phenylpropanolamine given alone [11][12][13], It should also be emphasized that the majority of patients pre ferred the combined treatment to estriol.…”

“…The traditional therapies in stress incontinence are surgery and pelvic floor exercise, but estrogens [1][2][3][4][5] and alpha-adrenoceptor agonists [6][7][8][9][10][11][12][13] have also been tried. Therapeutic response with estriol in urge and mixed uri nary incontinence has been reported to be higher com pared with the response in stress incontinence [ 1,5].…”

Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: A placebo-controlled, double-blind crossover study

“…␣-Adrenoceptor agonists have been assessed both clinically and urodynamically for the treatment of urinary stress incontinence [Ek et al, 1977;Lose and Lindholm, 1984;Collste and Lindskrog, 1987]. Therapeutic efficacy with the agents ephedrine, pseudoephedrine, and phenylpropanolamine is generally poor and is complicated or limited by side effects such as hypertension, piloerection, and central nervous system (CNS) stimulation.…”

Adrenoceptor Pharmacology: Urogenital Applications

“…Agents currently used for this purpose include the indirect acting sympathomimetic amines, such as pseudoephedrine and phenylpropanolamine, as well as the directly acting agonists, such as midodrine [41, 42, 43]. …”