1991
DOI: 10.1002/ps.2780330210
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Phenylpyrazoles, a new class of pesticide: Effects on neuromuscular transmission and acetylcholine responses

Abstract: Phenylpyrazoles constitute a newly developed class of chemicals with insecticidal and herbicidal properties. In acute toxicity experiments in rats, near‐lethal doses of phenylpyrazoles produce neurotoxic symptoms with an unknown mode of action. We have investigated the effects of two phenylpyrazoles, SLA4722 and SLA4685, in the frog neuromuscular junction and in the clonal muscle cell line BC3H‐1. In the frog neuromuscular junction SLA4722 at concentrations ⩾ 10−5 M caused a pronounced increase in the frequenc… Show more

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Cited by 5 publications
(2 citation statements)
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“…When aryl pyrazoles synthesized as herbicides were found to be insecticidal, their convulsive activity was not immediately recognized to result from GABA-antagonism (Klis et al, 1991). Cole et al (1993) reported subsequently that several compounds, including fipronil (27, Figure 96.11) (Colliot et al, 1992;Hatton et al, 1988), which has become a commercially successful insecticide, blocked the GABA-gated chloride ionophore with higher potency for a site in housefly than in mouse brain, offering the possibility of selective toxicity.…”
Section: Links Between Polychlorocycloalkane and Recent Heterocyclicsmentioning
confidence: 99%
“…When aryl pyrazoles synthesized as herbicides were found to be insecticidal, their convulsive activity was not immediately recognized to result from GABA-antagonism (Klis et al, 1991). Cole et al (1993) reported subsequently that several compounds, including fipronil (27, Figure 96.11) (Colliot et al, 1992;Hatton et al, 1988), which has become a commercially successful insecticide, blocked the GABA-gated chloride ionophore with higher potency for a site in housefly than in mouse brain, offering the possibility of selective toxicity.…”
Section: Links Between Polychlorocycloalkane and Recent Heterocyclicsmentioning
confidence: 99%
“…The experimental insecticide fipronil (Regent) (Rhone-Poulenc Ag. Co.), a phenylpyrazole, represents a new class of chemicals with herbicidal and insecticidal properties (Klis et al 1991a). Fipronyl, 1-[2,5-dicloro-4-trifluormethyl)-lH-pyrazole, has the substituents 3-cyano-4-[trifluoromethyl)sulfmyl]-5-amino.…”
Section: Introductionmentioning
confidence: 99%