Phenylureas. Part 1. Mechanism of the basic hydrolysis of phenylureas

Laudien, Robert; Mitzner, R.

doi:10.1039/b008532o

Cited by 28 publications

(17 citation statements)

References 17 publications

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“…Lateral lithiation of tetramethylurea, following an analogy from Claydens work, [11] gave only 5 % of the desired products 9 a and 9 b. Dimethylarylurea precursors were more successful; the major isolated product was disilylated 10 b or 11 b. [12] The same protocol was employed to prepare both bis-Ph 2 MeSi derivative 12 b and its SiEt 3 analogue 13 b. (Scheme 2).…”

Section: Waqar Rauf and John M Brown*mentioning

confidence: 99%

Catalytic Amide‐Mediated Methyl Transfer from Silanes to Alkenes in Fujiwara–Moritani Oxidative Coupling

Rauf

Brown

2008

Angew Chem Int Ed

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Section: Waqar Rauf and John M Brown*mentioning

confidence: 99%

Catalytic Amide‐Mediated Methyl Transfer from Silanes to Alkenes in Fujiwara–Moritani Oxidative Coupling

Rauf

Brown

2008

Angew Chem Int Ed

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“…Starting materials 2-ethylaniline and 5-bromo-2-carbaldehyde (5-bromofurfural), and the different boronic acids were purchased from Aldric or Alfa Aesar. Urea B was obtained according to a procedure reported previously ( Laudien and Mitzner, 2001 ). 1 H NMR spectra of the compounds were in accordance with literature data.…”

Section: Methodsmentioning

confidence: 99%

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

Sidarovich

Will

Anokhina

et al. 2017

eLife

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Small molecule inhibitors of pre-mRNA splicing are important tools for identifying new spliceosome assembly intermediates, allowing a finer dissection of spliceosome dynamics and function. Here, we identified a small molecule that inhibits human pre-mRNA splicing at an intermediate stage during conversion of pre-catalytic spliceosomal B complexes into activated Bact complexes. Characterization of the stalled complexes (designated B028) revealed that U4/U6 snRNP proteins are released during activation before the U6 Lsm and B-specific proteins, and before recruitment and/or stable incorporation of Prp19/CDC5L complex and other Bact complex proteins. The U2/U6 RNA network in B028 complexes differs from that of the Bact complex, consistent with the idea that the catalytic RNA core forms stepwise during the B to Bact transition and is likely stabilized by the Prp19/CDC5L complex and related proteins. Taken together, our data provide new insights into the RNP rearrangements and extensive exchange of proteins that occurs during spliceosome activation.DOI: http://dx.doi.org/10.7554/eLife.23533.001

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“…Earlier reports [12,15,[17][18][19] have shown that hydrolysis of phenylureas involved formation of isocyanic acids or isocynanates which are subsequently hydrolyzed to corresponding amines and carbon dioxide (Figure 4).…”

Section: Conversion Behaviormentioning

confidence: 96%

“…[17][18][19] Thus, it is necessary to investigate the influence of the leaving group, the poly(oxyalkylene)-amines, on the conversion rate. Figure 7 shows the residual contents of four dye-polyether derivatives in aqueous solutions buffered at pH 7-9 after treated at 130 C for 60 minutes.…”

Section: Effect Of the Polyether Structure On Thementioning

confidence: 99%

pH-Sensitive Dye-Polyether Derivatives as Dispersants for Its Parent Dye. Part 1: Synthesis and Hydrolysis Behavior

Dong

2010

Journal of Dispersion Science and Technology

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A series of dye-polyether derivatives, supposedly to be used as dispersants for parent dye, were synthesized by grafting poly(oxyalkylene)-amines based on differing both molecular weights and degrees of hydrophilicity/hydrophobicity, onto C.I. disperse red 60 via a stable urea linkage. The structures of the dye-polyether derivatives were characterized by FTIR, 1 H NMR, and SEC. The influence of pH on the hydrolysis behaviors of the dye-polyether derivatives were studied in buffered aqueous solutions within the pH range of 4 to 10. The hydrolysis of dye-polyether derivatives was pH dependent and relatively faster in mild alkaline buffer solution than in acidic one. The influence of poly(oxyalkylene)-amine structure on the hydrolysis behavior was also investigated; it was found that the hydrolysis rate is affected little by the molecular weight and increases with the increasing hydrophilicity of the poly(oxyalkylene)-amine.

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Phenylureas. Part 1. Mechanism of the basic hydrolysis of phenylureas

Cited by 28 publications

References 17 publications

Catalytic Amide‐Mediated Methyl Transfer from Silanes to Alkenes in Fujiwara–Moritani Oxidative Coupling

Catalytic Amide‐Mediated Methyl Transfer from Silanes to Alkenes in Fujiwara–Moritani Oxidative Coupling

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

pH-Sensitive Dye-Polyether Derivatives as Dispersants for Its Parent Dye. Part 1: Synthesis and Hydrolysis Behavior

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