Phenytoin-induced gingival overgrowth

Arya, Ravindra; Gulati, Sheffali

doi:10.1111/j.1600-0404.2011.01535.x

Cited by 37 publications

(27 citation statements)

References 48 publications

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“…It acts by blocking neuronal excitation by binding to sodium channels at rest, preventing them from becoming functional and generating excitatory action potentials (1) . The possibility of its use as a healing agent began to be investigated by primary experimental studies in the field of dentistry, when, in 1939, hypergranulation of gingival tissue was recognized as its adverse effect, which suggested possible use of this drug as a healing agent in wounds (2)(3) .…”

Section: Introductionmentioning

confidence: 99%

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

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RESUmoA fenitoína é um anticonvulsivante que vem sendo empregado na cicatrização de ferida. Os objetivos desta pesquisa foram: descrever como a produção científica apresenta o uso da fenitoína como agente cicatrizante e discutir sua aplicabilidade em feridas. Foi realizada, para tanto, revisão integrativa da literatura e análise pela hierarquia das práticas baseadas em evidências. Assim, analisaram-se 18 artigos que testaram a intervenção em feridas como úlceras de perna, por hanseníase, pé diabético, úlceras por pressão, tróficas, ferimentos de guerra, queimaduras, preparo da área receptora de enxerto, radiodermites e pós-extração de nevos melanocíticos. Uso sistê-mico da fenitoína no tratamento de fístulas e a hipótese do uso tópico no tratamento do vitiligo foram achados. Conclui-se que a fenitoína tópica é uma evidência científica. No entanto necessita-se de pesquisas robustas que sustentem o uso protocolar da fenitoína como mais uma opção de agente cicatrizante na prática clínica. Scientific production on the applicability of phenytoin in wound healing * CritiCal review AbStRActPhenytoin is an anticonvulsant that has been used in wound healing. The objectives of this study were to describe how the scientific production presents the use of phenytoin as a healing agent and to discuss its applicability in wounds. A literature review and hierarchy analysis of evidence-based practices was performed.Eighteen articles were analyzed that tested the intervention in wounds such as leprosy ulcers, leg ulcers, diabetic foot ulcers, pressure ulcers, trophic ulcers, war wounds, burns, preparation of recipient graft area, radiodermatitis and post-extraction of melanocytic nevi. Systemic use of phenytoin in the treatment of fistulas and the hypothesis of topical use in the treatment of vitiligo were found. In conclusion, topical use of phenytoin is scientifically evidenced. However robust research is needed that supports a protocol for the use of phenytoin as another option of a healing agent in clinical practice. dEScRiPtoRS Phenytoin Wound healing Evidence-based nursing Review RESUmEnLa fenitoína es un anticonvulsivo que se utiliza en la cicatrización de heridas. Los objetivos de esta investigación fueron: describir cómo la producción científica presenta el uso de la fenitoína como agente cicatrizante y discutir su aplicabilidad en las heridas. Se realizó una revisión integradora de la literatura y el análisis por la jerarquía de las prácticas basadas en las evidencias. Se analizaron 18 artículos que probaron la intervención en heridas como úlceras en la pierna por hanseniasis, pie diabético, úlceras por presión, tróficas, heridas de guerra, quemadura, preparación de la zona a injertar, radiodermitis y post extracción de nevos melanocíticos. Se encontró el uso sistémico de la fenitoína en el tratamiento de fístulas y la hipótesis del uso tópico en el tratamiento del vitíligo. Se concluye que la fenitoína tópica es una evidencia científica. Sin embargo, se necesita de investigaciones sólidas que sustenten el uso protocola...

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Section: Introductionmentioning

confidence: 99%

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

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“…One of phenytoin’s side effects, the gingival overgrowth, resulted in the focus on wound healing 32. Wounds (in rat models) treated with topical phenytoin, tissue edema, and inflammatory cell infiltration were significantly decreased; epidermal growth factor, vascular endothelial growth factor, and transforming growth factor-β were significantly increased 33,34…”

Section: Discussionmentioning

confidence: 99%

Topical phenytoin for the treatment of neuropathic pain

Kopsky¹,

Hesselink

2017

JPR

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We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especially for geriatric patients. Only in a few countries, compounded creams based on tricyclic antidepressants or other (co-)analgesics are available. Such topical analgesic creams, however, are easy to administer and have a low propensity for inducing side effects. We, therefore, developed a new topical cream based on 5% and 10% phenytoin and described three successfully treated patients suffering from neuropathic pain. All patients were refractory to a number of other analgesics. In all patients, phenytoin cream was effective in reducing pain completely, without any side effects, and the tolerability was excellent. The onset of action of the phenytoin creams was within 30 minutes. Phenytoin cream might become a new treatment modality of the treatment of neuropathic pain.

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“…It is estimated that half of all patients taking phenytoin are affected by gingival overgrowth [37], with even subtherapeutic phenytoin dosages being associated with overgrowth. The maximum occurrence of overgrowth is seen in the maxillary and mandibular anterior segments, with the overgrowth comprising apparently normal cells and fibres [36]. In dentulous patients, gingival overgrowth usually begins as a diffuse swelling in the interdental papilla region, then enlarges to coalesce and give a nodular growth.…”

Section: Anticonvulsantsmentioning

confidence: 99%

“…Phenytoin has been associated with gingival overgrowth since it first became available in 1938 [36]. It is estimated that half of all patients taking phenytoin are affected by gingival overgrowth [37], with even subtherapeutic phenytoin dosages being associated with overgrowth.…”

Section: Anticonvulsantsmentioning

confidence: 99%

Adverse drug reactions in the oral cavity

Sivaramakrishnan

Sridharan

2016

Drugs Ther Perspect

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Drugs prescribed for various systemic disorders have become a boon in increasing life span over the recent years, but are not without adverse effects. As regards to the oral cavity, the drug-related adverse effects include hard and soft tissue alterations, such as tooth or soft tissue discolouration, abnormal tooth movement, gingival overgrowth, oral ulceration, halitosis, abnormal salivary flow, etc. The use of alternative medications or temporarily avoiding the use of the drug might cause regression or stop the progression of the adverse effects. This narrative review aims to identify all the major hard and soft tissue manifestations produced by drugs in the oral cavity, the drugs causing them and their prevention and treatment.

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Phenytoin-induced gingival overgrowth

Cited by 37 publications

References 48 publications

Scientific production on the applicability of phenytoin in wound healing

Scientific production on the applicability of phenytoin in wound healing

Topical phenytoin for the treatment of neuropathic pain

Adverse drug reactions in the oral cavity

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