Phenytoin-Induced Lymphocytic Chemotaxis, Angiogenesis and Accelerated Healing of Decubitus Ulcer in a Patient with Stroke

Pitiakoudis, Michail; Giatromanolaki, Alexandra; Iliopoulos, Ioannis; Tsaroucha, AK; Simopoulos, Constantinos; Piperidou, Charitomeni

doi:10.1177/147323000403200213

Cited by 19 publications

(18 citation statements)

References 19 publications

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“…Again it is important to consider that this drug was considered safe, inexpensive and effective in wound healing by several researchers considered in this integrative review (4,(8)(9)(10)(11)(12)(16)(17)19,21) .…”

Section: Rev Esc Enfermmentioning

confidence: 99%

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

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RESUmoA fenitoína é um anticonvulsivante que vem sendo empregado na cicatrização de ferida. Os objetivos desta pesquisa foram: descrever como a produção científica apresenta o uso da fenitoína como agente cicatrizante e discutir sua aplicabilidade em feridas. Foi realizada, para tanto, revisão integrativa da literatura e análise pela hierarquia das práticas baseadas em evidências. Assim, analisaram-se 18 artigos que testaram a intervenção em feridas como úlceras de perna, por hanseníase, pé diabético, úlceras por pressão, tróficas, ferimentos de guerra, queimaduras, preparo da área receptora de enxerto, radiodermites e pós-extração de nevos melanocíticos. Uso sistê-mico da fenitoína no tratamento de fístulas e a hipótese do uso tópico no tratamento do vitiligo foram achados. Conclui-se que a fenitoína tópica é uma evidência científica. No entanto necessita-se de pesquisas robustas que sustentem o uso protocolar da fenitoína como mais uma opção de agente cicatrizante na prática clínica. Scientific production on the applicability of phenytoin in wound healing * CritiCal review AbStRActPhenytoin is an anticonvulsant that has been used in wound healing. The objectives of this study were to describe how the scientific production presents the use of phenytoin as a healing agent and to discuss its applicability in wounds. A literature review and hierarchy analysis of evidence-based practices was performed.Eighteen articles were analyzed that tested the intervention in wounds such as leprosy ulcers, leg ulcers, diabetic foot ulcers, pressure ulcers, trophic ulcers, war wounds, burns, preparation of recipient graft area, radiodermatitis and post-extraction of melanocytic nevi. Systemic use of phenytoin in the treatment of fistulas and the hypothesis of topical use in the treatment of vitiligo were found. In conclusion, topical use of phenytoin is scientifically evidenced. However robust research is needed that supports a protocol for the use of phenytoin as another option of a healing agent in clinical practice. dEScRiPtoRS Phenytoin Wound healing Evidence-based nursing Review RESUmEnLa fenitoína es un anticonvulsivo que se utiliza en la cicatrización de heridas. Los objetivos de esta investigación fueron: describir cómo la producción científica presenta el uso de la fenitoína como agente cicatrizante y discutir su aplicabilidad en las heridas. Se realizó una revisión integradora de la literatura y el análisis por la jerarquía de las prácticas basadas en las evidencias. Se analizaron 18 artículos que probaron la intervención en heridas como úlceras en la pierna por hanseniasis, pie diabético, úlceras por presión, tróficas, heridas de guerra, quemadura, preparación de la zona a injertar, radiodermitis y post extracción de nevos melanocíticos. Se encontró el uso sistémico de la fenitoína en el tratamiento de fístulas y la hipótesis del uso tópico en el tratamiento del vitíligo. Se concluye que la fenitoína tópica es una evidencia científica. Sin embargo, se necesita de investigaciones sólidas que sustenten el uso protocola...

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Section: Rev Esc Enfermmentioning

confidence: 99%

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

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“…It acts by increasing lymphocytic infiltration of the phenytoin-treated lesion. Anti-CD31 immunohistochemistry revealed dense CD31+ lymphocytic infiltration and increased angiogenesis in phenytoin-treated, but not control lesions [149]. Thus, phenytoin appears to enhances wound healing by stimulating lymphocytic chemotaxis and up-regulation of angiogenesis [149].…”

Section: Angiogenesismentioning

confidence: 96%

“…Topically applied Phenytoin, a promoter of angiogenesis, substantially accelerates the rate of ulcer healing [149]. It acts by increasing lymphocytic infiltration of the phenytoin-treated lesion.…”

Section: Angiogenesismentioning

confidence: 99%

“…Anti-CD31 immunohistochemistry revealed dense CD31+ lymphocytic infiltration and increased angiogenesis in phenytoin-treated, but not control lesions [149]. Thus, phenytoin appears to enhances wound healing by stimulating lymphocytic chemotaxis and up-regulation of angiogenesis [149]. Enhanced rates of ulcer healing can also be induced by induction of angiogenesis by implantation of bone marrow mononuclear cells (BM-MNCs), including endothelial progenitor cells [150].…”

Section: Angiogenesismentioning

confidence: 99%

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Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination

Kuffler¹

2012

TOCVJ

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Pressure ulcers, also called decubitus ulcers, are a common challenge of humanity. They are wounds initiated by pressure on the skin that blocks circulation causing the skin and underlying tissues to die. Without care, pressure ulcers continue to grow in diameter and depth and are exceptionally difficult to heal. They have probably always existed, and are present on Egyptian mummies. Pressure ulcers are a serious health issue, very painful, a significant physiological challenge, can shorten the life of a patient, are an emotional and financial burden to the patient, those who deal with them, and in the United States alone annually costs in excess over $10 billion dollars for care and prolonged hospitalization. Pressure ulcers can develop with as little as two hours of pressure, and because even a brief lapse in avoidance of pressure leads to ulcers, they are frequently impossible to prevent, even for the most conscientious patient with an extensive support group and unlimited financial resources. Therefore, enormous effort is required to find effective and reliable techniques for preventing the initiation of ulcers and eliminating them once they develop. This review looks at the various approaches presently used and in development for the treatment of pressure ulcers, evaluates which may be best in eliminating ulcers, and discusses combinations of techniques that may be most effective in eliminating pressure ulcers.

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“…The search for therapeutic options enhancing quicker healing of trophic ulcers continues. Various methods of treatment in practice are total plaster cast immobilization, saline or collagen dressings, topical phenytoin [1] or metronidazole [2] application, topical growth factors like platelet derived growth factor [3] (becalpermin), epidermal growth factor and other reconstructive surgical procedures. Most of the treatments mentioned above have been used for years.…”

Section: Introductionmentioning

confidence: 99%